Primary cutaneous large-cell anaplastic (Ki-1) lymphoma in a child

Meier, F. A.; Schaumburg-Lever, Gundula; Kaiserling, E.; Scheel-Walter, Hans-Gerhard; Scherwitz, C

doi:10.1016/0190-9622(92)70111-r

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Ulceration is also fre quent [9,10], as in the series of Krishnan et al [11 ], Banerjee et al |3] and more recently Beljaards et al [7], but erythroderma is exceptional [5]. The vascular proliferation of the lesion in our patient may account for its deceptive aspect, with contact bleeding.…”

Section: A Pseuclo Stewart-treves Aspectmentioning

confidence: 56%

“…Such a course is in contrast to that of extracutancous Ki-I lymphoma [5,9] or Ki-1 ALCL concomitant or subsequent to a cutaneous T-cell lymphoma [15], but this is controversial [3], Prognosis seems to be influenced by age (better in children) and of course by stage [19], However, we finally opted for chemotherapy because two new lesions appeared; our patient is free of symptoms 23 months after the end of treatment.…”

Section: Which Therapeutic Choice?mentioning

confidence: 98%

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Ki-1-Positive Large-Cell Cutaneous Lymphoma Mimicking a Stewart-Treves Angiosarcoma

et al. 1995

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Anaplastic large-cell cutaneous lymphomas (ALCL) represent a heterogeneous group. Primitive cutaneous lymphomas are exceptional, sometimes with a deceptive clinical aspect, but must be considered as a distinct clinicopathologic entity. We report a case of a cutaneous ALCL, appearing 7 years after a homolateral Hodgkin ganglionic lymphoma and occurring on a chronic lymphoedema of the arm. A Stewart-Treves angiosarcoma was suggested owing to its location, vascular aspect and low histologic differentiation. Immunohistochemistry was helpful in making the diagnosis of ALCL. Southern blotting analysis revealed a rearrangement of the β-chain of the T-receptor gene, thus suggesting the T-cell origin of this lymphoma.

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Section: A Pseuclo Stewart-treves Aspectmentioning

confidence: 56%

Section: Which Therapeutic Choice?mentioning

confidence: 98%

Ki-1-Positive Large-Cell Cutaneous Lymphoma Mimicking a Stewart-Treves Angiosarcoma

et al. 1995

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“…The former two have survived for a long time (13–65 months) after transplantation, while the latter experienced relapse at 61 days and died at 6 months after transplantation. We collected five cases with primary cutaneous ALCL treated with HSCT in the previous published work (Table ) . All of the five cases received auto‐HSCT and they survived for a long time (4–72 months at the time of report).…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic stem cell transplantation for cutaneous T‐cell lymphoma: Summary of 11 cases from two facilities in Japan and Brazil

Oka

Sugaya

Cury‐Martins

et al. 2015

The Journal of Dermatology

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Some patients with cutaneous T-cell lymphoma (CTCL) show a miserable clinical course and the only option that can induce long-term remission for advanced CTCL may be hematopoietic stem cell transplantation (HSCT). So far, studies on HSCT for CTCL patients have been limited. In this study, we summarized 11 cases with CTCL treated with HSCT, including nine cases in Japan and two cases in Brazil. The patients were five cases with mycosis fungoides (MF), two cases with Sézary syndrome (SS), three cases with anaplastic large cell lymphoma, and one case with primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTL-NOS). Currently, seven out of 11 cases are alive (at 13-108 months after transplantation) and four died at 15 days to 14 months after transplantation. When focusing on the eight patients who received allogeneic HSCT for MF/SS and PTL-NOS, all four patients at 45 years old or under are alive at present. One case showed relapse in the skin. On the other hand, one out of the other four patients at over 45 years old survived. Engraftment failure was seen in one case and all the other three cases experienced relapse. Although this is only a case series with a small number, our study has suggested that we should be careful about age when treating patients with MF/SS by allogeneic HSCT.

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“…Very few cases of pediatric C‐ALCL have been described (2–11,13) (Table 1). Almost all the patients received chemotherapy and suffered from recurrences (2,8).…”

Section: Discussionmentioning

confidence: 99%

“…Primary nodal anaplastic large cell lymphoma (ALCL) accounts for approximately 20% to 30% of large cell lymphomas during childhood (1,2). However, primary cutaneous anaplastic large cell lymphoma (C‐ALCL) has been rarely described in children (2–13). We present the unusual case of a 4‐year‐old boy who presented a rapidly developing ulcerated nodule on the nasal tip, which was diagnosed as CD30‐positive C‐ALCL.…”

mentioning

confidence: 99%