Primary Cutaneous Anaplastic Large Cell Lymphoma of the Nasal Tip in a Child

Santiago-et-Sánchez-Mateos, Diana; Hernández‐Martín, Ángela; Colmenero, Isabel; Mediero, Imelda G.; León, Álvaro; Torrelo, Antonio

doi:10.1111/j.1525-1470.2010.01245.x

Cited by 11 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 There have been only single case reports and small series of pediatric cALCL, and in these ALK staining was inconsistently performed. [24][25][26][27][28] We assume that our series is not population-based as cutaneous CD30 + LPD are diagnosed and treated either by dermatologists or pediatric oncologists. Nevertheless, our data suggest that ALK + cALCL might be more frequent than anticipated within the pediatric population, and recommend that all CD30 + LPD of the skin in children should be carefully analyzed for ALK expression.…”

Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

et al. 2012

View full text Add to dashboard Cite

Anaplastic large cell lymphomas are peripheral T-cell lymphomas that are characterized by a proliferation of large anaplastic blasts expressing CD30. In children, systemic anaplastic large cell lymphomas often present at advanced clinical stage and harbor translocations involving the anaplastic lymphoma kinase (ALK) gene leading to the expression of chimeric anaplastic lymphoma kinase (ALK)-fusion proteins. Primary cutaneous anaplastic large cell lymphoma is regarded as an ALK-negative variant confined to the skin and is part of the spectrum of primary cutaneous CD30-positive T-cell lymphoproliferative disorders. Thirty-three of 487 pediatric patients registered within the Anaplastic Large Cell Lymphoma-99 trial (1999 to 2006) presented with a skin limited CD30-positive lymphoproliferative disorder. In 23 of the 33 patients, material for international histopathological review was available, and the cases were studied for histopathological, immunophenotypical and clinical features as well as for breaks within the ALK gene. Five of 23 cases and one additional case (identified after closure of the trial) expressed ALKprotein. Complete staging excluded any other organ involvement in all children. Expression of ALK proteins was demonstrated by immunohistochemistry in all cases and the presence of breaks of the ALK gene was genetically confirmed in 5 evaluable cases. The histopathological and clinical picture of these skin-restricted ALK-positive lymphomas was indistinguishable from that of cutaneous anaplastic large cell lymphoma. Five children presented with a single skin lesion that was completely resected in 4 and incompletely resected in one. Three of these patients received no further therapy, 2 additional local radiotherapy, and one chemotherapy. All children remain in complete remission with a median follow up of seven years (range 1-8 years). We present 6 pediatric cases of ALK-positive primary cutaneous anaplastic large cell lymphomas. After thorough exclusion of systemic involvement, therapy confined to local measures seems to be sufficient to induce cure. ©2013 Ferrata Storti Foundation. This is an open

show abstract

Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

et al. 2012

View full text Add to dashboard Cite

show abstract

“…1 C-ALCL typically occurs in elderly individuals but very rarely in children. 1,2 To the best of our knowledge, cases of congenital primary C-ALCL have not been reported previously. This is a report of an unusual case of a 10-day-old neonate with an erythematous crusted plaque on the posterior aspect of the auricle present since birth.…”

Section: Introductionmentioning

confidence: 70%

“…4 ALK-positive S-ALCLs typically express EMA and carry a t(2;5)/NPM-ALK translocation. 1,2,4,12 In contrast, primary C-ALCL usually lacks both ALK activity and EMA expression. 4,5 In this case, immunohistochemical staining demonstrated that the tumor was CD30 + , ALK and EMA negative, and lacked the t(2;5)/NPM-ALK chromosomal translocation.…”

Section: Discussionmentioning

confidence: 90%

“…11 Nodal and extranodal site involvement is more common in children and adolescents with primary ALK-positive systemic ALCL (S-ALCL) than that in C-ALCL patients. 2 However, extracutaneous dissemination (such as in the regional lymph node) occurs in approximately 10% of C-ALCL patients. 11 This case showed regional lymph node involvement in the adjacent auricle.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,4 Primary C-ALCL is the second most common type of cutaneous T-cell lymphoma, accounting for approximately 10%-20% of cutaneous T-cell lymphoma cases. 5 Diagnosis of primary C-ALCL is based on the following criteria: (1) immunophenotypic expression of the CD30 antigen (on .75% of the tumor cells), (2) no clinical evidence of Lyp, (3) no history of or concurrent Lyp, MF, or other cutaneous lymphoma, and (4) no extracutaneous manifestations. 3 A few cases of primary C-ALCL have been described in children, 2,6,7 but to the best of our knowledge, the identification of primary C-ALCL in a 10-day-old neonate is the first reported case of congenital C-ALCL.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Congenital Primary Cutaneous Anaplastic Large-Cell Lymphoma

Seo¹,

Lee²,

Choi³

et al. 2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is the second most common type of primary cutaneous T-cell lymphoma. The median age of onset of C-ALCL is 60 years. Presented here is a case of congenital CD30-positive (CD30(+)) primary C-ALCL in a 10-day-old neonate who presented with a large erythematous indurative plaque in the right postauricular area. A systemic workup of the patient excluded other potential causes. The neonate was treated with wide excision, but chemotherapy or radiation therapy was not administered, as the patient's parents did not consent to such treatment. The patient has been monitored for 30 months after excision and there has been no disease recurrence. C-ALCL rarely occurs in children, and to the best of our knowledge, this is the first reported case of a neonate with congenital primary C-ALCL.

show abstract

Primary Cutaneous Lymphoma

Levy

Pope

2019

Harper's Textbook of Pediatric Dermatology

View full text Add to dashboard Cite

Primary Cutaneous Anaplastic Large Cell Lymphoma of the Nasal Tip in a Child

Cited by 11 publications

References 21 publications

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study

Congenital Primary Cutaneous Anaplastic Large-Cell Lymphoma

Primary Cutaneous Lymphoma

Contact Info

Product

Resources

About