Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11‐year old

Abstract

Polypoid fragment lined with nonkeratinized squamous epithelium with an atypical lymphoid infiltrate with nodular pattern (A, HE 2×). The atypical lymphoid cells are variable in size with small to medium centrocyte-like cells admixed with scattered larger centroblast-like cells. Single cell necrosis and mitotic figures are noted (B, HE 40×). The atypical cells are B cells that express strong CD20, CD10, and BCL6 as well as uniform BCL2. Fewer CD3+ T cells are noted surrounding the nodular areas. The CD21 staining highlights expanded and disrupted follicular dendritic cell meshwork consistent with atypical follicles. The proliferation index of the B cells (Ki-67) is moderate, approximately 60%. DNA PCR analysis using BIOMED2 immunoglobulin heavy chain gene consensus primers confirmed the presence of a clonal B-cell population

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

“…Infiltrated, ill‐defined erythematous patches or flat plaques surrounding a large nodule or tumour represent a distinctive appearance of this PCL 8,9 . Eyelid involvement as solitary non‐ulcerated nodules was reported in two patients of whom one was 11 years old 65,66 …”

“…8,9 Eyelid involvement as solitary non-ulcerated nodules was reported in two patients of whom one was 11 years old. 65,66 In conclusion, eyelids may not only be involved in primary and secondary lymphomas of ocular adnexal structures but also in PCLs. As PCLs are usually diagnosed by histopathological examination of extraocular lesions in dermatology clinics, the frequency of eyelid lymphomas reported by various disciplines has completely different rates.…”

Primary Cutaneous Follicle Center Lymphoma Presenting as a Solitary Nodule on the Forearm of an Adolescent Girl: A Case Report and Literature Review

“…3 In this age group, PCFCL is exceptionally rare with only 12 cases having been reported in the literature (Table 1). 1,[3][4][5][6][7][8][9] In this study, we report a case of PCFCL in a 16-year-old girl with unusual clinical and immunohistochemical presentation.…”

“…3 Pediatric PCFCL seems to be extremely rare with only 12 individuals less than 20 years of age reported in literature (Table 1). 1,[3][4][5][6][7][8][9] The underlying pathogenesis of PCFCL is not well understood and has been linked to chronic antigenic viral stimulation including Epstein Barr virus (EBV), Human Herpes Virus type 8 (HHV8) and Hepatitis B virus (HBV). 12 Primary cutaneous follicle center lymphoma (PCFCL) presents clinically as a solitary or grouped of plaques or nodules with a predilection of scalp, forehead, and trunk.…”

“…3 Follow up of the twelve published cases of pediatric PCFCL showed 9 cases were alive and disease free over a range of 42 weeks, one case disease recurred at 13 months follow-up, the remaining two patients' disease course was not reported (Table 1), our patient was referred to a specialist hospital for further management. 1,[3][4][5][6][7][8][9]…”