Primary Cutaneous Follicle Center Lymphoma

Skala, Stephanie L.; Hristov, Boris; Hristov, Alexandra C.

doi:10.5858/arpa.2018-0215-ra

Cited by 31 publications

(53 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most commonly affected areas are the head and neck, and the trunk (3-5,7). Multiple lesions are reported in 60% of the patients, 30-40% of which tend to occur in a localized area (8). Histologically, PCFCL is characterized by dense dermal infiltration of large centrocytes derived from germinal center B cells in a follicular, diffused, or mixed growth pattern (8).…”

mentioning

confidence: 99%

“…Multiple lesions are reported in 60% of the patients, 30-40% of which tend to occur in a localized area (8). Histologically, PCFCL is characterized by dense dermal infiltration of large centrocytes derived from germinal center B cells in a follicular, diffused, or mixed growth pattern (8). The neoplastic infiltrate spares the epidermis from which is separated by a grenz zone (7,8).…”

mentioning

confidence: 99%

“…On immunohistochemical analysis, the neoplastic lymphocytes express B-cell markers such as CD19, CD20, CD22, CD79A, and PAX5 and at least one follicle center marker which is BCL-6 and less commonly CD10 (8,9).…”

mentioning

confidence: 99%

“…The treatment options for PCFCL depend on the extent of the disease and include local or systemic treatment. For solitary lesions, radiation therapy and complete surgical excision constitute curative therapeutic approaches (6,8). Surgical resection is considered for small well-demarcated solitary lesions (6).…”

mentioning

confidence: 99%

“…Complete remission of PCFCL after radiation therapy is reported in up to 100% of the cases (5), whereas recent publications suggest that PCFCL can be successfully treated, with significantly lower doses of radiotherapy (8).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Salemis¹,

Koliarakis

Spiliopoulos

et al. 2020

IRDR

View full text Add to dashboard Cite

Primary cutaneous follicle center lymphoma (PCFCL) is defined as a low-grade B-cell non-Hodgkin's lymphoma, which primarily occurs and remains confined to the skin, without evidence of extracutaneous or systemic involvement at the time of diagnosis. PCFCL affecting the breast skin is an exceedingly rare entity with only two cases reported in the English literature. We present a case of PCFCL affecting the periareolar breast skin and review the relevant literature. Our patient was a 64-year-old female who presented with an erythematous plaque in the periareolar region of the left breast. The diagnosis of PCFCL was confirmed by a biopsy performed with a seven-month delay, as the tumor had been initially misdiagnosed as a benign lesion. The patient was successfully treated with local radiation therapy. PCFCL is an indolent lymphoma associated with an excellent prognosis. For localized lesions, skin-directed therapies mainly consisting of radiation therapy or complete surgical excision are curative therapeutic approaches, while systemic chemotherapy should be reserved for patients with extensive disease. This case highlights the need to consider PCFCL as an important differential diagnosis in patients presenting with non-resolving erythematous breast skin lesions. A timely biopsy should be obtained to avoid delays in the initiation of appropriate treatment.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Salemis¹,

Koliarakis

Spiliopoulos

et al. 2020

IRDR

View full text Add to dashboard Cite

show abstract

Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11‐year old

D'Alessandro

Spencer

et al. 2022

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Polypoid fragment lined with nonkeratinized squamous epithelium with an atypical lymphoid infiltrate with nodular pattern (A, HE 2×). The atypical lymphoid cells are variable in size with small to medium centrocyte-like cells admixed with scattered larger centroblast-like cells. Single cell necrosis and mitotic figures are noted (B, HE 40×). The atypical cells are B cells that express strong CD20, CD10, and BCL6 as well as uniform BCL2. Fewer CD3+ T cells are noted surrounding the nodular areas. The CD21 staining highlights expanded and disrupted follicular dendritic cell meshwork consistent with atypical follicles. The proliferation index of the B cells (Ki-67) is moderate, approximately 60%. DNA PCR analysis using BIOMED2 immunoglobulin heavy chain gene consensus primers confirmed the presence of a clonal B-cell population

show abstract

Adolescent with primary cutaneous follicle center lymphoma treated with rituximab

Devine,

Freiberg,

Reilly

2024

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Primary cutaneous follicle center lymphoma (PCFCL) is a cutaneous B-cell non-Hodgkin lymphoma (NHL), primarily seen in adults and only very rarely reported in children. Here, we describe an adolescent male with PCFCL of the scalp, treated with systemic rituximab monotherapy with a complete response.A 15-year-old male, with no significant medical history, presented with multiple erythematous lesions on his scalp. He first noted a nodule on his scalp approximately 9 months prior to presentation. This continued to grow larger and then spread with multiple other nodules appearing in the area, which prompted evaluation. He had no systemic symptoms such as fatigue, weight loss, fevers, or night sweats, and no other rashes or skin lesions. He had no significant travel history or insect bites. Physical exam was unremarkable, with the exception of a patch of scattered large papules in a 9 × 9 cm area with thinned hair overlying on his scalp (Figure 1). Laboratory evaluation included normal complete blood counts, kidney function, and liver function tests. Immunoglobulin G (IgG) level was normal at 1070 mg/dL. Anti-diphtheria antibodies, anti-tetanus antibodies,

show abstract

Primary Cutaneous Follicle Center Lymphoma

Cited by 31 publications

References 45 publications

Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11‐year old

Adolescent with primary cutaneous follicle center lymphoma treated with rituximab

Contact Info

Product

Resources

About