Primary contraction of skin grafts: a porcine preliminary study

Berezovsky, Alexander Bogdanov; Pagkalos, Vasileios A.; Silberstein, Eldad; Shoham, Yaron; Rosenberg, Lior; Krieger, Yuval

doi:10.4103/2347-9264.149372

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Excessive contraction might damage the graft due to the restricted mobility of the joints involved, which leads to an unsatisfactory functionalresult. In the present study, the graft presented a mean percentage of tissue contraction in the sham of 13.57%, similar to that in another study where the mean percentage of tissue contraction was 12.04% .…”

Section: Discussionsupporting

confidence: 90%

Photobiomodulation Increases Viability in Full‐Thickness Grafts in Rats Submitted to Nicotine

Souza¹,

Souza²,

Garcia³

et al. 2019

Lasers Surg Med

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Background and Objectives Photobiomodulation (PBM) therapy with 830 nm wavelength or 660 wavelength to compare the effects with parameters of 30 mW, 0.028 cm2, 9.34 seconds, and 3.64 J on the total integration of total skin grafts in rats submitted to nicotine. Study Design/Materials and Methods Sixty male Wistar rats were divided in six groups: Sham—skin‐grafting surgery; 830 nm—skin‐grafting followed by 830 nm irradiation; 660 nm—skin grafting followed by 660 nm irradiation; Nicotine—subjected to subcutaneous nicotine injection (2 mg/kg twice a day for 4 weeks), followed by skin grafting; Group Nicotine/830 nm—similar to Group Nicotine, followed by 830 nm irradiation; Group Nicotine/660 nm—similar to Group Nicotine, followed by 660 nm irradiation. The percentage contraction of the grafting tissue was evaluated through ImageJ®. The thickness of the epidermis, inflammatory infiltrates, and the space between the implanted tissue and receptor bed were determined by histology; and the expression of vascular growth factor and blood vessel density (factor VIII) were evaluated by immunohistochemistry. Results The PBM at both wavelengths promoted a facilitating effect on the integration of the skin graft under nicotine and had a more significant effect on the thickness of the epidermis and expression of angiogenesis without nicotine at a wavelength of 830 nm. Different wavelengths influence responses related to the viability of cutaneous grafts in rats submitted to nicotine. Conclusions The PBM with 830 nm and 660 nm promoted beneficial results in skin grafts submitted to the deleterious action of nicotine. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 90%

Photobiomodulation Increases Viability in Full‐Thickness Grafts in Rats Submitted to Nicotine

Souza¹,

Souza²,

Garcia³

et al. 2019

Lasers Surg Med

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“…During our surgical procedure, we procure three by seven inches (7.6 cm by 17.8 cm) cadaveric skin with each piece an initial size of 21 in2 (135.25 cm2) and a thickness between 0.015 to 0.020 inches (0.038 cm to 0.051 cm). To obtain a standardized final skin area of 100 cm2, the procurement size is appropriate after taking the 7% primary contraction and necessary trimming into account [15]. Such procurement size effectively avoids broken or disrupted skin graft commonly seen in large-size procurement and while still fitting a Zimmer Dermacarrier® for mesh expansion properly.…”

Section: Methodsmentioning

confidence: 99%

The Establishment of a High Standard Skin Bank in Taiwan as a Burn Care Pioneer

HF¹,

YC²,

I³

et al. 2022

COS

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Introduction: The establishment of skin banks is especially important in providing crucial cadaveric skin for burn treatments. Although the 2015 Formosa Fun Coast Explosion Disaster resulted in tragic casualties, it raised public awareness of the importance of having a well-functioning skin bank and led to the initiation of a skin bank development project, as well as the establishment of the first high standard skin bank in Taiwan. Methods: We standardized the size of our procured skin to avoid broken or disrupted skin graft, fit properly on a Zimmer Dermacarrier® for mesh expansion, and to be convenient for storage. We also integrated gamma radiation with the glycerol stored skin method for our skin preservation which effectively eradicates all contamination. Results: From 2016 to 2020, 453,100 cm2 of skin were procured from 62 donors and stored in the NTUH skin bank; 254,000 cm2 of which were utilized in the treatment of 75 patients. Between 2016 and 2017, 141 microbiological examinations were administered with six were positive. Since the introduction of gamma radiation, no contamination has been observed hereafter in our examinations. Conclusions: We report the success of establishing a high standard and well-functioning skin bank at NTUH that supply sufficient skin allografts in Taiwan. It is the first interhospital supply of charitable skin allografts across Taiwan. Being humanitarian, our skin bank is passing great love forward.

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“…Disadvantages include high secondary contracture rates, poor aesthetics due to the interstices if meshed and the tendency to either hyper or hypopigment compared to surrounding tissue, especially in darker-skinned patients ( 27 ). Though it is often recommended to increase the thickness of the graft due to the inverse relationship with contracture ( 28 ), no difference has been shown between thin (0.015in) and thick (0.025in) split-thickness grafts used for the hand in terms of range of motion or appearance ( 29 ). Split-thickness grafts may also be slightly less durable and at higher risk of injury than full-thickness or flap based alternatives ( 27 , 30 ).…”

Section: Principlesmentioning

confidence: 99%

Concepts in soft-tissue reconstruction of the contracted hand and upper extremity after burn injury

2023

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Burns and their subsequent contracture result in devastating functional and aesthetic consequences which disproportionally affect the upper extremity. By focusing on reconstruction with analogous tissue and utilizing the reconstructive elevator, function can be restored concomitantly with form and aesthetic appearance. General concepts for soft-tissue reconstruction after burn contracture are presented for different sub-units and joints.

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Primary contraction of skin grafts: a porcine preliminary study

Cited by 8 publications

References 16 publications

Photobiomodulation Increases Viability in Full‐Thickness Grafts in Rats Submitted to Nicotine

Photobiomodulation Increases Viability in Full‐Thickness Grafts in Rats Submitted to Nicotine

The Establishment of a High Standard Skin Bank in Taiwan as a Burn Care Pioneer

Concepts in soft-tissue reconstruction of the contracted hand and upper extremity after burn injury

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