Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival

Mizushima, Tsunekazu; Nomura, Motonari; Fujii, Makoto; Akamatsu, Hiroki; Mizuno, Hitoshi; Tominaga, Harumi; Hasegawa, Junichi; Nakajima, Kiyokazu; Yasumasa, Keigo; Yoshikawa, Masaharu; Nishida, Toshirou

doi:10.1007/s00595-009-4057-y

Cited by 48 publications

(52 citation statements)

References 20 publications

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“…A large cohort from US found that 80% of colorectal SRCC were diagnosed at stage III and IV versus 50% in non-SRCC (P < 0.01) [13]. This finding is consistent with the other published data, including cohort from Europe, and Asia [3,6]. SRCC of the large bowel are more likely to have transmural extension and lymph node involvement [3,12].…”

Section: Epidemiologic Featuressupporting

confidence: 84%

“…The reported frequency varies from 0.3 to 4.6% of all colorectal carcinomas with slight differences between western countries, Asia and Africa (figure 1) [3,[5][6][7][8][9][10][11][12]. The highest incidence of SRCC of the colon and rectum is reported in countries with low overall prevalence of colorectal cancer, such as Tanzania [10].…”

Section: Epidemiologic Featuresmentioning

confidence: 99%

“…The highest incidence of SRCC of the colon and rectum is reported in countries with low overall prevalence of colorectal cancer, such as Tanzania [10]. However, these data should be interpreted carefully because the majority of epidemiological data on SRCC of the colon and rectum are based on single institution studies [5,6,10], rarely from large population-based studies of colorectal cancer histology [11,12]. The mean age at diagnosis of colorectal SRCC reported in published series ranges from 48 to 70 years old [7,9].…”

Section: Epidemiologic Featuresmentioning

confidence: 99%

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Primary signet ring cell carcinoma of the colon and rectum

Arifi

Elmesbahi

Riffi³

2015

Bulletin du Cancer

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Section: Epidemiologic Featuressupporting

confidence: 84%

Section: Epidemiologic Featuresmentioning

confidence: 99%

Section: Epidemiologic Featuresmentioning

confidence: 99%

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Primary signet ring cell carcinoma of the colon and rectum

Arifi

Elmesbahi

Riffi³

2015

Bulletin du Cancer

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“…Signet ring cell histology has been uniformly associated with younger patient populations, later stage of presentation, and worse outcomes compared with non–signet ring adenocarcinomas [2, 3, 7-10]. This association has been made from several smaller single- and multi-institutional reports [3, 7-10] as well as population-based registry data[2], with stage-independent survival implied.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base

et al. 2012

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Purpose We evaluated clinical features and survival outcomes among patients with signet ring and mucinous histologies of colorectal adenocarcinoma using data from the National Cancer Data Base (NCDB). Methods Patients aged 18–90 years with colorectal adenocarcinoma diagnosed between 1998 and 2002 were identified from the NCDB. Site-stratified (colon vs rectum) survival analysis was performed using multivariate relative survival adjusted for multiple clinicopathologic and treatment variables. Results The study included 244,794 patients: 25,546 (10%) with mucinous, 2,260 (1%) with signet ring, and 216,988 (89%) with nonmucinous, non–signet ring adenocarcinoma. Mucinous and signet ring cancers were more frequently right-sided (60% and 62%, respectively) than were nonmucinous, non–signet ring adenocarcinomas (42%, P < .001). Signet ring histology was associated with a higher stage (P < .001), and 77.2% of signet ring tumors were high-grade lesions, compared with 20% of mucinous and 17% of non–signet ring, nonmucinous adenocarcinomas (P < .001). After adjustment for covariates, signet ring histology was independently associated with higher risk of death (HR 1.42, 95% confidence interval [CI] 1.33-1.51, and HR 1.57, CI 1.38-1.77, for tumors located in the colon and rectum, respectively). Mucinous tumors of the rectum (HR 1.22, CI 1.16-1.29), but not the colon (HR 1.03, CI 1.00-1.06), were associated with increased risk of death. Conclusion Signet ring cell adenocarcinomas of the colon and rectum and mucinous adenocarcinomas of the rectum are associated with poorer survival. These aggressive histologic variants of colorectal adenocarcinoma should be targeted for research initiatives to improve outcomes.

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“…1,27,28 Mizushima et al reported that the overall 5-year survival rate of patients with primary signet-ring cell carcinoma was signifi cantly lower than that of those with well or moderately differentiated adenocarcinoma and those with poorly differentiated adenocarcinoma or mucinous carcinoma (24.1% vs 77.5% and 57.7%, respectively). 29 Further studies comparing the survival associated with GCCs with that associated with common adenocarcinomas in stage-matched cases are required based on the clear evidence.…”

Section: Discussionmentioning

confidence: 99%

Goblet cell carcinoid of the rectum with lymph node metastasis: Report of a case

et al. 2011

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We report an unusual case of goblet cell carcinoid (GCC) of the rectum. A 75-year-old man was admitted to our hospital with anal bleeding, and a hard tumor was felt on the anterior wall of the lower rectum during rectal examination. We performed colonoscopy, and found a 30-mm type 2 tumor in the lower rectum and anal canal. Histological examination of biopsies revealed rectal adenocarcinoma. Based on these findings, we diagnosed rectal adenocarcinoma and performed Miles' operation with lymph node dissection. Histological examination revealed an invasive lesion composed of signet-ring-like cells. Seven regional lymph node metastases were seen microscopically. The tumor produced copious mucin, which was stained with Alcian blue. Immunohistochemistry was positive for synaptophysin, chromogranin A, CD56, carcinoembryonic antigen, p53, Ki-67, E-cadherin, and cytokeratin 20. The final diagnosis was GCC of the rectum.

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Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival

Abstract: The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer.

Cited by 48 publications

References 20 publications

Primary signet ring cell carcinoma of the colon and rectum

Primary signet ring cell carcinoma of the colon and rectum

Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base

Goblet cell carcinoid of the rectum with lymph node metastasis: Report of a case

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