Goblet cell carcinoid of the rectum with lymph node metastasis: Report of a case

Abstract

We report an unusual case of goblet cell carcinoid (GCC) of the rectum. A 75-year-old man was admitted to our hospital with anal bleeding, and a hard tumor was felt on the anterior wall of the lower rectum during rectal examination. We performed colonoscopy, and found a 30-mm type 2 tumor in the lower rectum and anal canal. Histological examination of biopsies revealed rectal adenocarcinoma. Based on these findings, we diagnosed rectal adenocarcinoma and performed Miles' operation with lymph node dissection. Histological examination revealed an invasive lesion composed of signet-ring-like cells. Seven regional lymph node metastases were seen microscopically. The tumor produced copious mucin, which was stained with Alcian blue. Immunohistochemistry was positive for synaptophysin, chromogranin A, CD56, carcinoembryonic antigen, p53, Ki-67, E-cadherin, and cytokeratin 20. The final diagnosis was GCC of the rectum.

Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1

“…The rectum is an unusual site for GCC, and less than 10 cases of GCC arising in the rectum have been reported [6]. Among them, there have been no patients with NF-1 as the present case, while a NF-1 patient with appendiceal GCC was recently described [7].…”

Goblet cell carcinoid of the rectum: a case report

“…Carcinoid-related tumors are classified as carcinoid (well-differentiated neuroendocrine neoplasm) and mixed endocrine-exocrine carcinoma by the World Health Organization histological classification of tumors of the appendix. The latter includes tubular carcinoid, GCC (mucinous carcinoid), and mixed carcinoid adenocarcinoma [7]. Höfler et al reported that GCCs are derived from undifferentiated stem cells and are different from typical carcinoids that originate from enterochromaffin cells (Kulchitsky) in the mucosal stroma [8].…”

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

“…There are rare cases of ostensibly primary extra-appendiceal GCC have been reported as stomach, duodenum, ampulla of Vater (21), jejunum, ileum, cecum, splenic flexure (22,23), ascending colon (24) and rectum (22,25,26,27,28).…”