Primary signet ring cell carcinoma of the colon and rectum

Arifi, Samia; Elmesbahi, Omar; Riffi, Afaf Amarti

doi:10.1016/j.bulcan.2015.07.005

Cited by 28 publications

(38 citation statements)

References 39 publications

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“…Puzzlingly, primary signet-ring cell carcinomas of the colon and rectum in humans account for fewer than 1% of all colorectal carcinomas (25). The cause of the high frequency of signet-ring cell carcinomas in the DMH SD model remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Updated Histologic Classification of Adenomas and Carcinomas in the Colon of Carcinogen-treated Sprague-Dawley Rats

Rubio

2017

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Lorenz and Stewart were the first to induce carcinomas in the colon of rodents (1). Since then, many workers have investigated the morphological, biological and molecular characteristics of colonic adenomas and carcinomas in mice and rats evoked by dimethylhydrazine (DMH) or by its metabolites (azoxymethane and methylazoxymethanol) (2) by spontaneous mutations (3) or genetic manupulations (4).In more recent years, several histological classifications of experimentally-induced colonic adenomas in rats have been proposed (5-13). Some researchers classify adenomas into tubular, villous and a mixed phenotype and tubulo-villous, others into adenomas with mild, moderate and severe dysplasia, and a third group regard adenomas as only those exhibiting severe dysplasia. Similarly, some authors classify invasive carcinomas into well-, moderately and poorly differentiated, and signet-ring cell carcinomas; others into tubular, mucinous, signet-ring cell and undifferentiated; and by a third group into scirrhous, tubular, papillary, tubular-papillary, mucinous, signetring, solid, undifferentiated, and mixed types (5-13). In contrast, Deschner (14), Maskens (15) and, more recently, Ward and Treuting (16) have asserted that adenocarcinomas often develop de novo, and not from adenomas, therefore, adenomas were not histologically classified.Despite the disparate classifications of colonic neoplasias in rodents, the general view has been that colonic carcinomas evolve from conventional (tubular, tubulo-villous or villous) adenomas (5-13). However, recent studies have disclosed additional histological phenotypes of colonic adenomas and carcinomas in DMH-treated Sprague-Dawley (SD) rats (17-19) as follows. Serrated adenomas and serrated carcinomas.Following activation of a KrasG12D mutant allele or inactivated Apc alleles, Feng et al. (3) found epithelium to be hyperplastic and serrated morphological features in the mouse colon, and Bongers et al. (4) found that transgenic expression of the epidermal growth factor receptor in conjunction with ligand heparin-binding epidermal growth factor in mice promoted caecal serrated polyps, but not serrated adenomas. Recently in 215 DMH-treated SD rats, tumours were found to be 1% serrated adenomas, 8% microtubular adenomas, 3% serrated carcinomas and 3% microtubular carcinomas (19). Thus, serrated adenomas and serrated carcinomas can be evoked in 6667 This Αrticle is freely accessible online.

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Section: Discussionmentioning

confidence: 99%

Updated Histologic Classification of Adenomas and Carcinomas in the Colon of Carcinogen-treated Sprague-Dawley Rats

Rubio

2017

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“…Since SRCC is a rare histological cancer subtype, current knowledge was mostly derived from single institution studies based on small population sizes [6, 23]. We utilized the SEER database to ensure a large sample size, and, to be specific, our study included a total of 776 patients.…”

Section: Discussionmentioning

confidence: 99%

“…It is a very aggressive form of colon cancer [1, 6] and is associated with poor biological behaviors, including poor differentiation [1, 2], perineural or lymphovascular invasion [1, 7], and lymph node involvement [4, 8]. From a molecular biological perspective, colorectal SRCC is also recognized as a unique tumor entity, inclining to have high levels of BRAF mutations, KRAS mutations, and CpG island methylation [7, 9, 10].…”

Section: Introductionmentioning

confidence: 99%

Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis

Huang

Chen

et al. 2016

Gastroenterology Research and Practice

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Background. In general, younger age is associated with better survival in patients with colon cancer. In this study, we aim to analyze the impact of age on cancer-specific survival (CSS) in patients with signet-ring cell carcinoma (SRCC) of the colon, a particularly aggressive type of colon cancer. Methods. Information on patients with SRCC of the colon with no distant metastasis was extracted from the US Surveillance, Epidemiology, and End Results (SEER) database. An X-tile plot was used to determine the optimal cutoff age at diagnosis. Results. A total of 776 patients were included in data analysis. The X-tile program revealed an optimal cutoff at 35 years of age. A higher percentage of stage III disease and a higher percentage of N2 disease were observed in patients ≤ 35 years of age. The multivariate Cox proportional model demonstrated that patients ≤ 35 years of age were more likely to have a poorer survival outcome compared with patients aged >35 years (HR 1.411, 95% CI 1.032–1.929, and P = 0.031). Conclusion. In contrast to the association of younger age with better survival in colon cancer patients, younger age (≤35 years) is associated with poorer survival outcome in patients with SRCC of the colon without distant metastasis.

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“…[1] While the incidence is relatively high (over 80%) in the elder at the age of over 50, colorectal carcinoma (CRC) in children is extremely rare with the reported incidence of only 1.3 cases per million children, [2] accounting for roughly 1% of the surgical patients with CRC. [3,4] Colon signet ring cell carcinoma (CSRCC) in children is an aggressive type of cancer known for its high incidence of metastasis with poor prognosis. [3,5–7] Unfortunately, CSRCC is often diagnosed at the very late stage, likely due to its low morbidity and nonspecific clinical manifestations, [5] which may result in insufficient medical awareness of CSRCC.…”

Section: Introductionmentioning

confidence: 99%

Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient

Li¹,

Huang²,

Wang³

et al. 2017

Medicine

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Rationale:All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been reported elsewhere, which may suggest some linkage between them.Patient Concern:A 13-year-old boy presented with progressive abdominal pain and melena for 3 months. Computed tomography (CT) scan and endoscopic ultrasonography showed significant abnormality in the transverse colon characteristic of marked mural thickening. The biopsy results indicated signet ring cell carcinoma.Diagnoses:A 13-year-old male patient with advanced colon signet ring cell carcinoma. In addition, immature but not mature ganglion cells could be observed in almost all of the slices of the resected nontumorous area of the specimen.Interventions:The transverse colon tumor was resected and the subsequent histopathological examination confirmed the diagnosis of primary colon signet ring cell carcinoma. Then the patient received adjuvant chemotherapy and biological target therapies subsequently.Outcomes:After 6 cycles of adjuvant chemotherapy and biological target therapies, metastasis was however detected within a year.Lessons:In this case, a 13-year-old male patient with advanced colon signet ring cell carcinoma were presented. Unexpectedly, immature ganglion cells could be observed in almost all of the slices of the resected nontumorous area of the specimen. It is critical to raise medical awareness and improve the diagnosis and treatment of the signet ring cell carcinoma. This malignancy and the immature ganglion cells may be associated, possibly caused by some unidentified genetic defects. Genome sequencing, histopathological examination, and long-term follow-up of young patients with related diseases, would help further reveal the potential relationship between tumorigenesis and ganglion cells’ immaturity, contributing to understanding the molecular mechanisms.

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Primary signet ring cell carcinoma of the colon and rectum

Cited by 28 publications

References 39 publications

Updated Histologic Classification of Adenomas and Carcinomas in the Colon of Carcinogen-treated Sprague-Dawley Rats

Updated Histologic Classification of Adenomas and Carcinomas in the Colon of Carcinogen-treated Sprague-Dawley Rats

Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis

Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient

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