Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient

Li, Huili; Huang, Kun; Wang, Hui; Wang, Lin; Yang, Ming; Wang, Lixia; Lin, Rong; Liu, Hongli; Gao, Jinbo; Shuai, Xiaoming; Liu, Xinghua; Tao, Kaixiong; Wang, Guobin; Wang, Zheng

doi:10.1097/md.0000000000007036

Cited by 4 publications

(3 citation statements)

References 34 publications

(30 reference statements)

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“…[ 16 ] In 2017, Li et al provided a case report and reviewed all the literature in this area. [ 17 ] Thibodeau et al reported that a 15-year-old boy was admitted with abdominal pain and diagnosed with ascending and successfully treated colon SRCC with colectomy. [ 18 ] The patient had been alive for 6 months.…”

Section: Discussionmentioning

confidence: 99%

“…All pediatric patients detected in the past 20 years are presented in Table 2. [4,5,[13][14][15][16][17][18][19] Even the most extensive series consisted of only four cases. [16] In 2017, Li et al provided a case report and reviewed all the literature in this area.…”

Section: Discussionmentioning

confidence: 99%

“…Alive for eight months Pandey et al [16] Li et al [17] 2017 13/M Abdominal pain melena Mid-transverse colon…”

Section: Left Hemicolectomymentioning

confidence: 99%

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A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

Erginel

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Signet-ring cell adenocarcinoma of the colon is well-recognized in adult patients who are extremely rare and not well-documented in children. Our study aims to raise awareness about this rare disease and its long-term outcomes. METHODS: We retrospectively evaluated patients with signet-ring cell colon adenocarcinoma. RESULTS: Six patients, three boys and three girls, with a mean age of 14.83 (range, 13–17 years), presented with signs of intestinal obstruction and were diagnosed with signet-ring cell colon adenocarcinoma. All patients had air-fluid levels on abdominal X-ray. Abdominal ultrasonography of all patients revealed subileus. Abdominal computed tomography was performed in five patients, and pre-operative colonoscopy was conducted in two patients before the emergency intervention. All of the patients underwent emergent exploratory laparotomy with the preliminary diagnosis of acute abdomen. In two patients, debulking surgery followed by a stoma was performed. The remaining four patients were treated with anastomosis following intestinal resection. All girls had metastases on the ovary. One of the patients died due to the burden of multiple metastases in the early period, and three died in the sixth post-operative year. We have been following the remaining two patients since then. CONCLUSION: Although signet-ring cell carcinomas (SRCCs) are rare, they should be considered in the differential diagnosis of acute abdomen and intestinal obstruction in pediatric patients. Despite early diagnosis and treatment, SRCC has a poor prognosis in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

Erginel

2023

Ulus Travma Acil Cerrahi Derg

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Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review

Carrim

Gaxa

Schyff

et al. 2017

Journal of the Egyptian National Cancer Institute

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Colorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at presentation and the aggressive tumor nature. Patients present with abdominal pain, vomiting, constipation, abdominal distension, rectal tenesmus, iron-deficiency anemia, change in bowel habit and weight loss. Rectal bleeding is an uncommon presentation in children. Bowel obstruction presents frequently in children compared to adults. In 90% of pediatric cases, colorectal carcinoma occurs sporadically. In 10%, predisposing conditions and syndromes are identified. We present a case study of a 12-year-old female with advanced colorectal cancer without a predisposing disease or syndrome, who received radio-chemotherapy ten weeks prior to radical abdominopelvic surgery, followed by radio-chemotherapy postoperatively, with a positive outcome.

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Primary signet ring cell carcinoma with tubular adenoma of the rectum

Yang

Shi

et al. 2020

Medicine

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Rationale: Among the various forms of colorectal carcinomas, primary signet ring cell carcinoma (SRCC) of rectum is infrequent. Primary SRCC with adenoma is even rarer. Due to its low morbidity and lack of obvious manifestations at early stages, it is difficult to make an early diagnosis and perform surgical intervention in time. Herein, we reported a case of primary SRCC with tubular adenoma of rectum and also performed a review of the literature of such cases, in hopes of expanding the general understanding regarding such cases. Patient concerns: A 61-year-old male patient presented with rectal bleeding for 1 week. Diagnoses: A neoplasm could be palpated through a rectal examination, with a size of 4.0 cm by 3.0 cm, at a distance of 5 cm from the anal edge. Magnetic resonance imaging examination and colonoscopies were performed to confirm the finding, and 4 tissue specimens were obtained for histopathologic biopsy. The result of biopsy was high-grade intraepithelial neoplasia with an adenoma component. Interventions: Surgical resection was performed, and histopathologic and immunohistochemical staining examination of the resection confirmed the diagnosis of SRCC with tubular adenoma. Outcomes: The patient was discharged from hospital 12 days postsurgery, without any complications. Further chemotherapy and supportive treatments were suggested to him and will be followed at a local hospital. Lessons: Primary rectal SRCC has a rather low morbidity. Furthermore, a rectal SRCC with adenoma which was presenting in this case is even more rare. Besides lack of clinical characters, delay of diagnosis and treatment frequently occur. So far, a surgical procedure has still been one of the most effective treatments. Considering of metastasis and the poor prognosis, early diagnosis, in-time radical resection, and a comprehensive followed treatment are recommended for a higher 5-year overall survival.

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Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient

Cited by 4 publications

References 34 publications

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon

Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review

Primary signet ring cell carcinoma with tubular adenoma of the rectum

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