Primary anaplastic large-cell lymphoma of the skin

A Case of Mycosis Fungoides after CD30 Positive Anaplastic Large Cell Lymphoma

“…The CD30, or Ki-1, antigen is a marker of activation and is inducible on both T and B cells by stimulation with a variety of antigens: thus it is not specific for any lineage (1)(2)(3). Positive staining for CD30 is largely membraneous with, in some cases, a paranuclear dot-like reaction (1).…”

“…Positive staining for CD30 is largely membraneous with, in some cases, a paranuclear dot-like reaction (1). Among the CD30+ lymphoproliferative disorders, three major groups can be distinguished (2,3). The first is a group of primary cutaneous CD30+ disorders, including primary cutaneous CD30+ anaplastic and nonanaplastic LCLs, LP, and rare cases of primary cutaneous HD.…”

“…In our patient, the clinical and histological differential diagnosis of the preexisting nodule on the popliteal fossa included primary ALCL, LP, and HD. Primary cutaneous CD30+ LCLs are defined by the following criteria: 1) predominance (>75%) or large clusters of CD30+blast cells in the initial skin biopsy specimen; 2) clinically, no evidence ofLP (chronic, recurrent, self-healing eruption); 3) no prior or concurrent LP, MF, or other type of (cutaneous) lymphoma; 4) no extracutaneous localization at presentation (1)(2)(3)(4)(5)(6). LP is a chronic, recurrent, self-healing disease (5)(6)(7).…”

“…Recently, it has been suggested that there are many morphological, immunophenotypical, and molecular-genetic similarities among cutaneous lymphomas ranging from lymphomatoid papulosis (LP) to mycosis fungoides (MF), anaplastic large cell lymphoma (ALCL) , and Hodgkin's disease (HD) and that they are all variants of the same lymphoma or portions of a spectrum oflymphoproliferative disorders (1)(2)(3). We describe a case in whom MF arose two years after the completion of treatment for ALCL.…”