Immunohistology of Skin Tumors

Wick, Mark R.; Swanson, Paul E.; Patterson, James W.

doi:10.1016/b978-0-443-06652-8.50018-1

Cited by 5 publications

(5 citation statements)

References 297 publications

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“…Apocrine nevus can be distinguished from tubular apocrine adenoma with the latter having anastomosing tubular structures, frequent luminal papillations, and a more fibrotic stroma. 4 S100 positivity is seen more often in eccrine-derived lesions rather than apocrine-derived lesions, 15 whereas EMA positivity is more common in malignancies of apocrine and eccrine derivation. Sudoriferous tumors are typically positive for cytokeratin, carcinoembryonic antigen (CEA), CA72.4, CD15, and p63.…”

Section: Discussionmentioning

confidence: 99%

“…15 Both apocrine and eccrine glands contain and secrete CEA. Apocrine nevus can be distinguished from tubular apocrine adenoma with the latter having anastomosing tubular structures, frequent luminal papillations, and a more fibrotic stroma.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical stains have been investigated in apocrine lesions, such as apocrine nevi. 15 All the diagnoses in these cases were made based on routine (hematoxylin and eosin) staining; no additional immunohistochemical stains or ultrastructural studies were performed on the current specimens. 15 Both apocrine and eccrine glands contain and secrete CEA.…”

Section: Discussionmentioning

confidence: 99%

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Pure Apocrine Nevus

Cordero

Royer

Rush³

et al. 2012

The American Journal of Dermatopathology

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Apocrine nevus is a rare tumor composed of increased mature apocrine glands and ductal structures within a fibrous stroma, located predominantly in the reticular dermis. They have been reported in association with apocrine carcinoma, extramammary Paget disease, and syringocystadenoma papilliferum; less commonly a pure apocrine nevus is identified, unassociated with another apocrine proliferation. Clinically apocrine nevi may appear as solitary or multiple nodules or plaques on the scalp, presternal skin, though they are seen most commonly in the axillae. We describe 4 cases of pure apocrine nevus, all of which appeared clinically as painless or mildly tender skin-colored axillary masses, 2 of which were bilateral. In each case, the lesions appeared in adulthood, and patients denied knowledge of congenital or childhood presence. Patients denied pruritis, discharge, bleeding, or antecedent trauma. Grossly, the specimens consisted of subcutaneous, multicystic ill-defined nodules. Biopsy showed prominent apocrine glands composed of irregularly columnar luminal cells with eosinophilic cytoplasm arranged in a somewhat organoid pattern filling the reticular dermis and extending into the subcutaneous adipose tissue. The glandular luminal cells displayed decapitation secretion. There was a paucity of pilosebaceous units. In one case, the overlying epidermis was papillomatous. The deepest portion of one specimen had lactational change simulating a lactational adenoma. No atypia was seen in either the glandular structures or the stroma. The adjacent sebaceous and eccrine structures were normal. The histologic features and immunohistochemical profile in relation to other apocrine lesions will be reviewed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pure Apocrine Nevus

Cordero

Royer

Rush³

et al. 2012

The American Journal of Dermatopathology

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“…Considering the patient's findings on imaging, additional differential diagnoses include metastatic urothelial carcinoma and other metastatic malignancies of gynecologic origin. Immunohistochemical markers such as cytokeratin 5/6, p40, and p63 may be used at the pathologists' discretion to confirm that the tumor is truly of squamous origin, and to rule out metastatic carcinomas from different sites [20,21] . In this case, given the patient's clinical history and presentation, a diagnosis of cutaneous metastases from the patient's primary cervical squamous cell carcinoma was favored.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

McCarthy

Laucirica

2014

CRCP

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Squamous cell carcinoma of the cervix was once the most common gynecologic cancer in the world, accounting for significant morbidity and mortality. With the advent of routine Papanicolaou screening in the United States during the latter half of the twentieth century, cervical cancer now accounts for a much smaller proportion of cancer deaths. Despite the advances that have been made in screening and early detection, women of low socio-economic status and immigrants from other countries who may not have access to health care continue to present with high-stage disease. Manifestations of advanced disease include direct invasion of structures adjacent to the cervix and distant metastases to the lung, bone, and liver. In approximately 0.5-1 percent of cases, metastases to the skin and soft tissue occur, most commonly to the abdominal wall and vulva, followed less frequently by the perineum and extremities. This particular manifestation has come to be regarded as a sign of terminal disease, with most patients surviving 3-6 months despite chemotherapy. Clinically, this may not be a diagnosis that is anticipated by the pathologist examining the biopsy. We present the case of a 55 year-old woman with a history of untreated squamous cell carcinoma of the cervix who presented with rapidly spreading, painful erythematous papules of the vulva, lower anterior abdominal wall, and proximal lower extremities. This case highlights a rare presentation of metastatic squamous cell carcinoma of the cervix, and underscores the importance of obtaining adequate clinical history, investigating a wide range of diagnoses as part of the differential diagnosis, and distinguishing primary cutaneous squamous cell carcinoma from a metastasis.

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“…The sensitivity and specificity of several immunological stains that may be used in the diagnosis of KS is shown in Table 1. Most vascular conditions are likely to be immunoreactive for the endothelial markers factor VIII‐related antigen, CD31 and CD34 11 . Thrombomodulin and UEA‐1 are not widely used in contemporary surgical pathology practice as specific endothelial markers.…”

Section: Usefulness Of Immunohistochemistrymentioning

confidence: 99%

Immunohistochemistry in Kaposiâs sarcoma

Pantanowitz¹,

Otis²,

Dezube³

2010

Clinical and Experimental Dermatology

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The importance of immunohistochemistry (IHC) to our understanding, ability to confidently diagnose and treat Kaposi's sarcoma (KS) has grown steadily in the past few decades. IHC has been performed on many KS specimen types, with > 100 different primary antibodies. Therefore, it is not surprising that IHC has helped unravel the histogenesis, understand the pathogenesis and facilitate the diagnosis of KS and identify novel therapeutic targets in the disease. This paper reviews the literature on the use of IHC in the study of KS.

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Immunohistology of Skin Tumors

Cited by 5 publications

References 297 publications

Pure Apocrine Nevus

Pure Apocrine Nevus

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

Immunohistochemistry in Kaposiâs sarcoma

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Immunohistology of Skin Tumors

Cited by 5 publications

References 297 publications

Pure Apocrine Nevus

Pure Apocrine Nevus

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

Immunohistochemistry in Kaposiâs sarcoma

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Product

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Immunohistochemistry in Kaposiâs sarcoma