A Case of Mycosis Fungoides after CD30 Positive Anaplastic Large Cell Lymphoma

Lee, Mi-Woo; Chi, Doo-Hyun; Choi, Jee‐Ho; Sung, Kyung Jeh; Moon, Kee‐Chan; Koh, Jai‐Kyoung

doi:10.1111/j.1346-8138.2000.tb02206.x

Cited by 5 publications

(9 citation statements)

References 12 publications

(20 reference statements)

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“…reported a case of MF coexisting with spontaneously regressing CD30 + tumours that showed a good prognosis and demonstrated clinical and histological overlap with cutaneous T‐cell lymphoma (CTCL). Lee et al 12 . reported a case of MF followed by CD30 + ALCL, supporting morphological, immunological, and molecular genetic similarities among cutaneous lymphoma ranging from LyP to MF and ALCL 1 .…”

Section: Reportmentioning

confidence: 82%

Coexistence of CD30-positive anaplastic large cell lymphoma and mycosis fungoides

Kang

Chang

Choi

et al. 2002

Clinical and Experimental Dermatology

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Primary cutaneous T-cell lymphomas, including lymphomatoid papulosis, mycosis fungoides and CD30+ anaplastic large cell lymphoma (ALCL) overlap clinicopathologically and form part of a spectrum of lymphoproliferative disorders. There have been several case reports of these diseases coexisting. We describe a 59-year-old Korean man who presented with a recurrent, solitary CD30+ ALCL of 25 years' duration as well as patch stage mycosis fungoides of 11 years' duration. Such occurrences may represent different clinical manifestations of the same clonal T-cell abnormality, and provide further insight into the pathogenesis of these related disorders.

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Section: Reportmentioning

confidence: 82%

Coexistence of CD30-positive anaplastic large cell lymphoma and mycosis fungoides

Kang

Chang

Choi

et al. 2002

Clinical and Experimental Dermatology

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“…Additionally, MF may transform into a CD30+ large cell lymphoma, thereby carrying a poor prognosis. In contrast, only a few reports in the literature document the coexistence of pcALCL and MF with varying gene rearrangement results …”

Section: Discussionmentioning

confidence: 93%

“…A few reports in the literature document the coexistence of pcALCL and MF with varying gene rearrangement results. Lee et al . reported a case of MF occurring two years after a pcALCL nodule.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of cutaneous T‐cell lymphomas (CTCL) are diagnosed as mycosis fungoides (MF), followed by lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and borderline cases between the latter two . Rarely, patients may present with multiple types of CTCLs . The usual clinical course of these lesions is an indolent one, while transformed MF typically follows a more aggressive course.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Rarely, patients may present with multiple types of CTCLs. [4][5][6][7][8] The usual clinical course of these lesions is an indolent one, while transformed MF typically follows a more aggressive course.…”

Section: Introductionmentioning

confidence: 99%

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Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T‐cell receptor gene rearrangement analysis: a case series of four patients and review of the literature

et al. 2015

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Lymphomatoid Papulosis Associated with Mycosis Fungoides: Clinicopathological and Molecular Studies of 12 Cases

Gallardo¹,

Costa²,

Bellosillo³

et al. 2004

Acta Dermato-Venereologica

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The association of mycosis fungoides and a primary cutaneous CD30+ lymphoproliferative disorder has been reported and probably represents different clinical aspects of a unique T-cell monoclonal expansion. In this study, 12 patients (6 men and 6 women) presented with lymphomatoid papulosis and mycosis fungoides. A TCRgamma gene rearrangement study was performed by an automated high-resolution PCR fragment analysis method on skin biopsy specimens taken from the different clinical lesions in each patient. An indolent clinical course was observed in the majority of patients. T-cell clonality was identified in 7 of 12 lymphomatoid papulosis lesions (58%) and in 6 skin biopsies of plaque stage mycosis fungoides (50%). In each individual case, where T-cell clonality was detected, both mycosis fungoides and lymphomatoid papulosis specimens exhibited an identical peak pattern by automated high-resolution PCR fragment analysis, confirming a common clonal origin. Only one case showed a clonal TCRgamma rearrangement from the lymphomatoid papulosis lesion, which could not be demonstrated in the mycosis fungoides specimen. The demonstration of an identical clone seems to confirm that both disorders are different clinical manifestations of a unique T-cell monoclonal proliferation. Our results also seem to confirm that the association of mycosis fungoides with a primary cutaneous CD30+ lymphoproliferative disorder usually carries a favourable prognosis.

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A Case of Mycosis Fungoides after CD30 Positive Anaplastic Large Cell Lymphoma

Cited by 5 publications

References 12 publications

Coexistence of CD30-positive anaplastic large cell lymphoma and mycosis fungoides

Coexistence of CD30-positive anaplastic large cell lymphoma and mycosis fungoides

Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T‐cell receptor gene rearrangement analysis: a case series of four patients and review of the literature

Lymphomatoid Papulosis Associated with Mycosis Fungoides: Clinicopathological and Molecular Studies of 12 Cases

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