Primary anaplastic large cell (KI-1 positive) lymphoma of the mandible as the initial manifestation of acquired immunodeficiency syndrome in a pediatric patient

Willard, Craig C.; Foss, Robert D.; Hobbs, Timothy; Auclair, Paul L.

doi:10.1016/s1079-2104(95)80018-2

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…To the best of our knowledge, the present case reports the first gingival ALCL, which mimicked a benign hyperplastic lesion as the first clinical manifestation of AIDS. Positivity to HIV was reported in 3 cases [2, 11]. About 14% of the ALCL cases were ALK-negative [17]; our case is the fourth case reported [17, 22].…”

Section: Discussionmentioning

confidence: 70%

“…Mechanisms other than the loss of immune surveillance appear to be involved with HIV-associated malignances [11]. In our case, the oral lymphoma with distinctive clinical appearance and associated with periodontitis occurred in an HIV-seropositive patient and was the first manifestation of AIDS.…”

Section: Discussionmentioning

confidence: 77%

“…Most of the tumors were located in the gingiva (5 cases), followed by the palate (3 cases), tongue (2 cases), retromolar trigone (2 cases), lip (2 cases), floor of the mouth (1 case), and buccal mucosa (1 case). The main radiographic findings were bone resorption [11, 12, 17], and the main diagnostic hypothesis more frequent is nonspecific infection (4 cases) [2, 13, 16]. To the best of our knowledge, the present case reports the first gingival ALCL, which mimicked a benign hyperplastic lesion as the first clinical manifestation of AIDS.…”

Section: Discussionmentioning

confidence: 92%

“…A couple of ALCL cases have been reported, although some were the B-cell phenotype now classified as an anaplastic type of diffuse large B-cell lymphoma [10]; therefore, these cases were excluded from the present review. ALCL is characterized by proliferation of the anaplastic large lymphoid cells with abundant cytoplasm and strong expression of CD30 antigen; however, its final diagnosis is a challenge for oral pathologists [8, 11–17]. Two distinct clinical entities of ALCL are recognized by the World Health Organization (WHO) lymphoma classification: cutaneous and systemic lymphomas [1, 5].…”

Section: Introductionmentioning

confidence: 99%

“…From the scientific literature, we found around 15 cases of ALCL in the oral cavity [2, 6, 8, 11–17, 21, 22]. Only 5 cases of ALCL located in gingiva have been reported in the literature [12, 17, 22], and our case is the fourth reported occurrence of ALCL in the oral cavity of a HIV-seropositive patient [2, 11]. Besides, this paper is the first to present an unusual case of oral ALK-negative ALCL that mimicked a benign hyperplastic lesion as a first clinical manifestation of AIDS.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

Rozza-De-Menezes

Ferreira

Capella

et al. 2013

Case Reports in Dentistry

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This paper presents an unusual case of gingival ALCL, which mimicked a benign hyperplastic lesion that occurred in a 57-year-old white man representing the first clinical manifestation of acquired immunodeficiency syndrome (AIDS). The patient was referred to the Dental Clinic of PUCPR complaining of a lobulated nodule on the gingiva of his upper central incisors. The presence of advanced chronic periodontitis and dental plaque raised suspicion for a benignancy. An excisional biopsy was performed, and large pleomorphic cells with an abundant cytoplasm, sometimes containing prominent nucleoli and “Hallmark” cells, were observed through hematoxylin and eosin staining. The tumor cells showed strong CD30 expression, EMA, Ki-67, and LCA, and negative stain for p80NPM/ALK, CKAE1/AE3, CD20, CD3, CD56, and CD15. The final diagnosis was ALCL (ALK-negative). Further laboratory tests revealed positivity for human immunodeficiency virus (HIV). The patient was submitted to chemotherapy, but four months after diagnosis, the patient died due to pneumonia and respiratory failure. Oral anaplastic large-cell lymphoma (ALCL) is a rare disorder. Only 5 cases involving the gingiva have been reported, and to our knowledge, this is the first case reported of the ALCL, which mimicked a hyperplastic benignancy as the first clinical manifestation of AIDS.

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