Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis

Abstract

HTy-Ac improved the oxidative events and returned pro-inflammatory proteins expression to basal levels probably through JAK/STAT, MAPKs and NF-κB pathways. HTy-Ac supplement might provide a basis for developing a new dietary strategy for the prevention of rheumatoid arthritis.

The phenolic fraction of extra virgin olive oil modulates the activation and the inflammatory response of T cells from patients with systemic lupus erythematosus and healthy donors

“…In this sense, defective T‐cell pathway signaling occurs in SLE and it has been directly implicated in causing epigenetic abnormalities that result in lupus‐like autoimmunity . Moreover, different studies have shown that EVOO and some EVOO bioactive components are able to modulate ERK phosphorylation in different inflammatory model s , including pristane‐induced SLE in mice . In our study, we found that ERK phosphorylation was significantly increased after PHA stimulation compared with nonstimulated cells in patients with SLE and healthy donors.…”

Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High‐Fat Diet in Mice through PPAR‐α and Nrf2 Upregulation with Concomitant SREBP‐1c and NF‐kB Downregulation

“…At the hepatic level, activated PPAR‐α enhances lipolysis, mitochondrial β‐oxidation of FAs, and TAG storage, while reducing lipogenesis . Although PPAR‐α activation is accomplished by FAs such as docosahexaenoic acid (DHA; C22:6 n‐3), there is no clear evidence showing this property for EVOO, a product that is capable of upregulating Nrf‐2 signaling in other experimental models . According to these backgrounds, the aim of this work was to test the influence of a combination of low doses of DHA and EVOO supplementation on the activation level of transcription factors PPAR‐α, Nrf2, NF‐κB, and SREBP‐1c, in relation to the attenuation of liver (i) steatosis, (ii) pro‐inflammation, (iii) oxidative stress, (iv) pro‐lipogenic status, and (v) preservation of n‐3 long‐chain PUFAs (LCPUFA) content altered in HFD‐fed mice.…”

Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial

“…For instance, in an experimental collagen-induced arthritis (CIA) mice arthritis model, extra-virgin olive-oil polyphenol extract containing hydroxytyrosol was proven to exert anti-inflammatory and joint-protective effects. When given at the doses of 100 and 200 mg/kg/day, these extracts reduced the levels of proinflammatory mediators (TNF-α, IFN-γ, IL-1 β, IL-6, IL-17 A, and PGE2) [26] and decreased serum IgG1 and IgG2a, cartilage olimeric matrix protein (COMP), and metalloproteinase-3 (MMP-3) [27].…”

“…Our results nicely fit with literature data for rheumatoid arthritis models. Hydroxytyrosol acetate (HTy-Ac) is able to lower the activation of the Janus kinase-signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinases (MAPKs), and nuclear transcription factor-kappa B (NF-κB) pathways and thus to downregulate the arthritic process in CIA mice [26,27]. In human fibroblast-like synoviocytes (FLSs) derived from arthritic tissues, resveratrol inhibits COX-2/PGE2 expression and reduces p65 phosphorylation [29].…”