Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2

Moghaddam, Akbar Hajizadeh; Eslami, Ali; Jelodar, Sedigheh Khanjani; Ranjbar, Mahdy; Hasantabar, Vahid

doi:10.1016/j.bbr.2023.114300

Cited by 10 publications

(7 citation statements)

References 67 publications

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“…The results exposed here follow our data previously obtained. In fact, fibroblasts exposed to UVA rays, especially after two hours, show an increase of intracellular ROS levels and of the associated apoptotic molecular events (increase in the Bcl2/Bax ratio), involving the Nrf2 signal transduction pathways [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

et al. 2023

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This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin’s ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.

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Section: Discussionmentioning

confidence: 99%

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

et al. 2023

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“…After absorption, quercetin binds to albumin and is transported primarily to the liver via the portal vein and to other organs, including the small intestine, colon, and kidney. In the liver, it undergoes O-methylation, glucuronidation, and/or sulfation to form its conjugates quercetin-3-glucuronide, quercetin-30-sulfate, and isorhamnetin-3-glucuronide [ 31 ]. Conjugation reactions with glucuronic acid and/or sulfate appear to be the most common type of flavonoid metabolic pathway.…”

Section: Quercetin Particularitiesmentioning

confidence: 99%

Quercetin, a Flavonoid with Great Pharmacological Capacity

Carrillo-Martinez,

Flores-Hernández,

Salazar-Montes

et al. 2024

Molecules

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Quercetin is a flavonoid with a low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive chlorine species (ROC), which act as reducing agents by chelating transition-metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, different pharmacological properties of quercetin have been described, such as carcinostatic properties; antiviral, antihypertensive, and anti-inflammatory properties; the ability to protect low-density lipoprotein (LDL) oxidation, and the ability to inhibit angiogenesis; these are developed in this review.

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“…Researchers are working to achieve higher bioavailability of polyphenols through various means. One promising approach to increase the bioavailability of quercetin is the use of nanophytosomes, because quercetin-loaded nanophytosomes have been found to have a more significant impact on antioxidant enzymes [ 151 ]. Similar results have been observed for epigallocatechin-3-gallate [ 152 ].…”

Section: Polyphenols As Regulators Of Transcription Factorsmentioning

confidence: 99%

Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

Костенко¹,

Akimov²,

Gutnik³

et al. 2023

Heliyon

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Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2

Cited by 10 publications

References 67 publications

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

Quercetin, a Flavonoid with Great Pharmacological Capacity

Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

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