Quercetin, a Flavonoid with Great Pharmacological Capacity

Abstract

Quercetin is a flavonoid with a low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive chlorine species (ROC), which act as reducing agents by chelating transition-metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, different pharmacological properties of quercetin have been described, such as carcinostatic properties; antiviral, antihypertensive, and anti-inflammatory properties; the ability to protect low-density lipoprotein (LDL) oxidation, and the ability to inhibit angiogenesis; these are developed in this review.

Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties

“…Quercetin, a flavonoid abundant in fruits and vegetables, is known for its potent antioxidant properties, attributed to its ability to donate electrons and scavenge free. Numerous studies have highlighted quercetin’s role in protecting against oxidative stress-induced damage and its potential therapeutic benefits in neurodegenerative disease radicals [ 82 ]. Similarly, biotin, an essential B vitamin, has been shown to enhance antioxidant defences and promote mitochondrial function, thereby mitigating oxidative damage [ 83 ].…”

Enhancing bioactive content in Malus sylvestris peel extract for antioxidant source using microwave-assisted extraction (MAE) and predicting the potential of ant nests

“…Prediction of ant nest potential using the Structural Activity Relationship (SAR) approach with pass online 26 Based on SAR analysis, it has been identified that bioactives present in apple peel exhibit the highest potential as Free Radical Scavengers (0.754). Additionally, these bioactives show potential as Lipid Peroxidase Inhibitors (0.671), Antihypercholesterolemics (0.577), and Lipid Metabolism Regulators (0.468) (see Figure 2).…”

The Role of Natural Products in Diabetic Retinopathy

“…Quercetin is a major representative of the flavonoid family that can be found in various vegetables and fruits. Quercetin plays an important role in treating numerous diseases by exerting anti-inflammatory, antioxidant, anti-neovascular, and neuroprotective effects [ 119 , 120 , 121 ]. In diabetic rats, quercetin supplementation increased neurotrophic factors and inhibited cytochrome c and caspase-3, thereby protecting the retina from oxidative stress and apoptosis.…”