Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nanophytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model. Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated. Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P<0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P<0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P<0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P<0.05). Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.
Background and Objectives: Alzheimer's disease (AD) is a neurodegenerative disease accompanied by common emotional symptoms such as anxiety and fear. The aim of this study was investigating the anti-anxiety and antioxidant effects of sumac extract and its nano-phytosome, in streptozotocin (STZ)-induced rat model of Alzheimer's disease Materials and Methods: In this experimental study, 35 male Wistar rats were divided into five groups (control, positive control, Alzheimer, and Alzheimer with (40mg/kg) doses of sumac extract and nano-phytosome -sumac). For the induction of Alzheimer model, STZ (3 mg / kg) was injected intracerebroventricularlly. 21 days after gavage, plus maze test was performed to evaluate anxiety behavior in the rats. In the end, catalase and superoxide dismutase enzyme's activity and malondialdehyde levels were measured in the cerebral cortex. Statistical analysis was performed using one-way ANOVA followed by Tukey's test.
Results:The results showed that STZ increased anxiety-like behaviors (p=0.001), malondialdehyde (MDA) level (p<0.017), and decreased catalase and superoxide dismutase activity in the Alzheimer group (p<0.001); while treatment with sumac nano-phytosome reduced anxiety-like behaviors (p=0.002), increased catalase and superoxide dismutase activity and decreased MDA level in cerebral cortex (p=0.003).
Conclusion:The results suggested that sumac nano-phytosome due to improving the bioavailability may reduce STZinduced anxiety-like behaviors and oxidative stress in rat model of AD.
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