Preventive Effect of Ganoderma lucidum on Paracetamol-induced Acute Hepatotoxicity in Rats

Rahman, Mohibur; Hossain, Saddam

doi:10.3329/jsr.v5i3.14055

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…The disruption of hepatocyte membrane permeability by APAP intoxication allows these enzymes to leak out from the liver cytosol into the blood circulation, thus inducing necrosis and inflammatory responses [ 25 , 29 ]. Our findings are consistent with those of some previous studies [ 25 , 26 ]. Pretreatment with EECM tended to alleviate the activities of the serum transaminases, ALP and LDH, thereby demonstrating that EECM maintained membrane integrity and restricted the leakage of hepatic enzymes via a mechanism that is not yet completely understood.…”

Section: Discussionsupporting

confidence: 94%

“…The animal experiments were designed based on the findings of the effective dose of acetaminophen as an agent for liver damage at subacute exposure while the outcomes of the study are the effects of C. macroptera investigated at multiple doses with some modifications ( Figure 1 ) [ 13 , 26 ]. Briefly, the animals were randomly divided into seven groups with six rats in each group.…”

Section: Methodsmentioning

confidence: 99%

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Satkara (Citrus macroptera) Fruit Protects against Acetaminophen‐Induced Hepatorenal Toxicity in Rats

Paul

Islam

Tanvir

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Although Citrus macroptera (Rutaceae), an indigenous fruit in Bangladesh, has long been used in folk medicine, however, there is a lack of information concerning its protective effects against oxidative damage. The protective effects of an ethanol extract of Citrus macroptera (EECM) against acetaminophen-induced hepatotoxicity and nephrotoxicity were investigated in rats. Rats (treatment groups) were pretreated with EECM at doses of 250, 500, and 1000 mg/kg, respectively, orally for 30 days followed by acetaminophen administration. Silymarin (100 mg/kg) was administered as a standard drug over a similar treatment period. Our findings indicated that oral administration of acetaminophen induced severe hepatic and renal injuries associated with oxidative stress, as observed by 2-fold higher lipid peroxidation (TBARS) compared to control. Pretreatment with EECM prior to acetaminophen administration significantly improved all investigated biochemical parameters, that is, transaminase activities, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transferase activities and total bilirubin, total cholesterol, triglyceride and creatinine, urea, uric acid, sodium, potassium and chloride ions, and TBARS levels. These findings were confirmed by histopathological examinations. The improvement was prominent in the group that received 1000 mg/kg EECM. These findings suggested that C. macroptera fruit could protect against acetaminophen-induced hepatonephrotoxicity, which might be via the inhibition of lipid peroxidation.

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Section: Discussionsupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Satkara (Citrus macroptera) Fruit Protects against Acetaminophen‐Induced Hepatorenal Toxicity in Rats

Paul

Islam

Tanvir

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…125 mcg G. lucidum extract is the dose-dependent manner which significantly reduced serum LDH levels compared with that of positive control group. These results are in agreement with Rahman and Hossain, (2013) 31 who has studied the protective effect of G. lucidum on acute hepatotoxicity using paracetamol for the induction of liver damage and demonstrate that the G. lucidum has significant hepatoprotective activity against paracetamol -induced acute hepatotoxicity and reported that G. lucidum significantly decreased the plasma levels of LDH in rats nearly to those of the normal control. This coincides also with Xu et al, (2017) 32 who has studied cardioprotective effects of G. lucidum polysaccharides (GLPS) on DOXinduced cardiotoxicity and associated serum LDH release which is also an indicator of cell injury and found that DOX injection significantly elevated serum levels of LDH ; however GLPS pre-treatment significantly reversed the levels of these cardiac enzymes and obviously prevented LDH leakage as well as significantly decreased the serum levels of LDH.…”

Section: Biochemical Parameters Lactate Dehydrogenase (Ldh) Levelsupporting

confidence: 91%

Trends in Assessment of Ganoderma lucidum Methanol Extract Against MRSA Infection In Vitro and In Vivo with Nutrition Support

Soliman

Abdelbary

Yonus

et al. 2022

Journal of Advanced Pharmacy Research

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Objectives: Ganoderma lucidum, a traditional Chinese mushroom, has been widely used for the management of antibacterial infection and nutrition. This study was conducted to investigate the protective effect of Ganoderma lucidum methanol extract against MRSA infection in vitro and in vivo in case of made special diet for albino rates. Methods: Ganoderma lucidum was collected then form extracted using methanol and characterized using GC-MS. In vitro assay to evaluate anti-MRSA activity was done using Agar well diffusion method with MIC determined. In vivo, total of 32 male and female albino rats of 6-8 weeks with a body weight of (115 -120) g were divided into four groups with 8 rats in each: negative control, positive control injected IP with 200 micro of MRSA (8*10^8 CFU/mouse) and 2 groups have injected IP with 200 micro of MRSA (8*10^8 CFU/mouse) with G. lucidum methanol extract dose of (125 and 250 mcg respectively) for 3 weeks, blood samples and lungs were collected for examination. Results: Treatment of albino rats with Ganoderma lucidum methanol extract reduced the histological changes due to lung inflammation induced by MRSA infection and significantly reduced increasing in the lactate dehydrogenase (LDH) levels. Also, it shows a good antibacterial effect against MRSA colonies growth which supports the antibacterial therapeutic effect of G. lucidum. Conclusion:Present study concluded that G. lucidum methanol extract has potent antibacterial effect against MRSA infected albino rats, and it's effective as protective against lung inflammation induced by MRSA infection.

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“…Therefore searching for agents capable of reducing the levels of Pb from the body could be considered as one of the important preventive measures. Very recently, we have reported that the oral administration of G. lucidum extract prevents paracetamol-induced hepatotoxicity in rats [ 19 ] and erythrocyte hemolysis in rats [ 20 ], suggesting oral administration of this medicinal mushroom extract can play, at least partially, role in the reduction of Pb-induced hemolysis and related anemia. In this study, we thus investigated whether the chronic administration of Pb results in an increased sensitivity of erythrocyte to hemolysis and, if so, then whether the oral administration of the extract of G. lucidum decreases it.…”

Section: Introductionmentioning

confidence: 99%

Oral Administration ofGanoderma lucidumto Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia

Hossain

Bhowmick

Islam

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum. Three groups of rats, control, PbA-exposed, and G. lucidum (Gl)+PbA, were used. PbA (3 mM) was administered via drinking water and G. lucidum extract by gavage at 300 mg/Kg BW/day for 12 weeks. Afterwards, the rats were killed and washed RBCs were subjected to hemolysis in the presence of Fenton's reagents. Hemolysis was determined by estimating the amount of released hemoglobin. The levels of lipid peroxide (LPO) and GSH were determined from RBC membranes and whole RBCs, respectively. The levels of TNFα and LPO also were determined from hepatic tissues. The RBCs of PbA-exposed rats displayed significantly higher sensitivity to hemolysis than those of the Gl+PbA rats. The levels of LPO increased and GSH decreased in the RBCs, with concomitant increases in the levels of hepatic TNFα and LPO in the PbA-exposed rats. The degree of hemolysis was significantly low in the RBCs of Gl+PbA rats, concurrently with amelioration of hepatic parameters. Finally, the study suggests that PbA-induced-hemolysis and related oxidative-toxicity might be minimized by consumption of G. lucidum.

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Preventive Effect of Ganoderma lucidum on Paracetamol-induced Acute Hepatotoxicity in Rats

Cited by 8 publications

References 10 publications

Satkara (Citrus macroptera) Fruit Protects against Acetaminophen‐Induced Hepatorenal Toxicity in Rats

Satkara (Citrus macroptera) Fruit Protects against Acetaminophen‐Induced Hepatorenal Toxicity in Rats

Trends in Assessment of Ganoderma lucidum Methanol Extract Against MRSA Infection In Vitro and In Vivo with Nutrition Support

Oral Administration ofGanoderma lucidumto Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia

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