Preventive and curative effects of curcumin on the development of gastric inflammatory diseases in rats

Abstract

Preventive and curative effects of curcumin on experimental acute and chronic gastric ulcers were investigated to validate its clinical application on a remedy for peptic ulcer. Intraduodenal administration of curcumin, 5-20 mg/kg, inhibited gastric acid secretion in pylorus-ligated rats, and oral administration prevented ethanol-induced acute gastric mucosal lesions. Curcumin (20-80 mg/kg, p.o.) dose-dependently prevented both serotonin-induced gastric mucosal lesions and compound 48/80-induced gastric mucosal lesions in rats. Furthermore, oral administration of curcumin, 10-80 mg/kg, twice daily for 10 days, significantly accelerated the healing of acetic acid-induced chronic gastric ulcer and promoted mucosal regeneration in the ulcerated portion in a dose-related manner. Cimetidine prevented the formation of ethanol-induced gastric mucosal lesions, but not of serotonin-induced and compound 48/80-induced gastric mucosal lesions. Consecutive administration of cimetidine showed a marked acceleration in the healing of acetic acid-induced ulcer. Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, showed anti-ulcerogenic effects similar to those oberved for curcumin. The present results indicate that curcumin exhibits gastric cytoprotection in the acute lesion models and ulcer healing promotion in the chronic ulcer model. The preventive and curative effects of curcumin might be due to an increase in the mucosal defensive mechanism through its antioxidant property and inhibition of NO or cytokine-mediated inflammation.

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

“…An oral dose of curcumin at 20–80 mg/kg twice daily has been reported in the treatment of gastric ulcers in rats [ 38 ], whereas no exact dosage has been reported for humans. Although the developed sponge systems in this study contained a relatively low drug content of 3 mg/capsule, the amount of curcumin released was approximately 10 times greater compared to the plain curcumin, as shown in Figure 8 .…”

Efficacy and Safety of some Medical Herbs on Gastric Ulcer Induced by Aspirin in Rats

“…In addition, curcumin acts as gastroprotectant against irritants by increasing mucin secretion in rabbits. It also decreases indomethacin induced increment in the luminal acid level, which is beneficial to prevent acid-induced aggravation of ulcer by its potent antioxidant activity through scavenging of reactive oxygen species (ROS) and protection of gastric peroxidase [75].…”

Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats

“…Previous studies have indicated that it exhibits anti-infection properties (8) and has the ability to inhibit inflammatory cell proliferation, invasion, and angiogenesis, through numerous molecular targets and mechanisms of action (18,19). Curcumin has been shown to reduce gastric acid production and concentration (20). WRS has been reported to produce band-like hemorrhagic lesions in the glandular portion of the stomach (21).…”