Prevention of stress in rainbow trout (Oncorhynchus mykiss) fed diets containing different doses of glucan

Jeney, Galina; Galeotti, Marco; Volpatti, Donatella; Jeney, Zsigmond; Anderson, D.P.

doi:10.1016/s0044-8486(97)00042-2

Cited by 178 publications

(139 citation statements)

References 39 publications

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“…With more than 14 000 scientific publications, it is not surprising that glucan is the most commonly used natural immunomodulatory [23,26] . The ability of glucans to regulate and significantly improve various physiological processes from defense reaction to stress regulation [27,28] , cholesterol level or regulation of blood sugar is well documented (for review see [26] ). In this study, we evaluated the effects of glucan in patients after primary therapeutic solution of malignant disease and in the period after surgery and after irradiation or chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of NK Cells During Complex Cancer Treatment

et al. 2016

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AIM:The role of glucan in potentiation of immune system is well established, including effects on cancer development. In this study, we focused on effects of short term glucan supplementation in patients during complex cancer treatment. MATERIALS AND METHODS:We measured the levels of leptin and changes in NK cell numbers after oral application of 200 mg/day of glucan. RESULTS: We found significant improvement in total numbers of NK cells. Levels of leptin remained unchanged. CONCLUSIONS: Our findings show the significant effects of glucan supplementation on induction of NK cell, suggesting that addition of glucan to the diet could be beneficial for prevention of cancer remission. The glucan-supplemented group exhibited some improvements in psychic conditions, nutritional state and overall feeling of well-being. Longer supplementation seems to be necessary.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of NK Cells During Complex Cancer Treatment

et al. 2016

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“…Immunostimulation is an important tool in aquaculture to increase resistance to pathogens [3] especially since substances, such as β-glucan, occur naturally in the environment and are thus less likely to raise concerns about residues in food fish and the environment [4]. Previous studies on β-glucan have highlighted a time and dose dependency of the effects [1,[33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

“…These substances, known as immunomodulators or immunostimulants, are utilized to increase general protection against disease or to overcome the immunosuppressive effects of stress [1]. Generally substances that have immunostimulatory functions act as pathogen associated molecular patterns (PAMPs) and induce an immune response by interaction with pattern recognition receptors (PRRs).…”

Section: Introductionmentioning

confidence: 99%

Time and concentration dependency of MacroGard® induced apoptosis

Miest

Hoole

2015

Fish & Shellfish Immunology

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In previous studies an effect of β-glucan on apoptosis in fish was noted and in this investigation we determine the time and concentration dependency of this effect. Primary cell cultures of pronephric carp cells were incubated for 6, 24, 48 h with various concentrations ranging from 0 -1000 μg/ml of MacroGard ® β-glucan. Apoptosis was monitored via acridine orange staining. Results indicate a clear effect of time and concentration on the induction of apoptosis in vitro, with only concentration ≥ 500 μg/ml causing significantly higher percentages of apoptotic cells. Apoptosis was detected after 6 h. This concentration dependent effect has to be considered when studying apoptosis in relation to immunostimulation.

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“…Cook et al (2001) reported that lower doses of β-1.3/1.6 glucan are an important immunostimulant induced immune response, whereas overdoses (1.0%, 2.0%) caused immunosuppression. In studies on natural products with immunostimulant properties, it has been reported that the lowest doses of these products caused the highest NBT activity and this result was supported by lymphocyte and eosinophil cell counts (Jeney et al, 1997;Şahan et al, 2015). In fish, phagocytosis is the primary mechanism of the non-specific immune response to pathogenic microorganisms.…”

Section: Discussionmentioning

confidence: 96%

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Şahan¹,

Duman²,

COLAK³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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The effect of the Yersinia ruckeri infection in the different tissues of 225 rainbow trout (Oncorhynchus mykiss) fed with rosehip (Rosa canina) was researched by evaluating a range of factors such as hematological and histopathological findings, non-specific immune parameters, liver antioxidant parameters, and then determined mortality and relative percentage survival (RPS) rates.The study comprises control groups (C+, C−) and rosehip experimental groups (REGs): R10 (10%), R20 (20%) and R30 (30%). Following the 50-day feeding period, the fish were infected with Y. ruckeri and then blood, liver, spleen and kidney samples were taken. RBC, WBC, Hb, Hct and RBC indices, non-specific immune parameters, NBT, phagocytic activity and leukocyte formulas all significantly increased in R20 compared to other groups. Antioxidant parameters SOD, CAT and GSH values increased in the R20 and R30 groups, and the lowest RPS value was detected in R30 at 26.31%, while it increased in the R20 group to 42.09%. R30 showed no significant hematological and immunological effects, however, the immune cells were suppressed. In this research, R20 was determined to be the ideal dose, taking into account both health indicators and hematological parameters, as a defense mechanism against Y. ruckeri, showing the best antibacterial and antioxidant effects.

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Prevention of stress in rainbow trout (Oncorhynchus mykiss) fed diets containing different doses of glucan

Cited by 178 publications

References 39 publications

Reconstruction of NK Cells During Complex Cancer Treatment

Reconstruction of NK Cells During Complex Cancer Treatment

Time and concentration dependency of MacroGard® induced apoptosis

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