Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?

Domingues, Alexandre; Sartori, Alexandrina; Golim, Márjorie de Assis; Valente, Lígia M. M.; Rosa, Larissa Camargo da; Ishikawa, Larissa Lumi Watanabe; Siani, Antonio C.; Viero, Rosa Marlene

doi:10.1016/j.jep.2011.06.021

Cited by 22 publications

(20 citation statements)

References 58 publications

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“…Among eighteen triterpenoid compounds isolated from ethanol extract of U. laevigata stem barks, ursolic acid (124) and 3β-hydroxy-30-methoxy-6-oxo-urs-12,19(20)-dien-28-oic acid (1 4 5) inhibited the activities of α-glucosidase with the IC 50 value of 16 72.2 and 49 73.7 μM, respectively . In addition, Domingues et al (2011) reported that hydroethanol extract of U. tomentosa stem bark reduce the glycemic level and delay the diabetes incidence in a dose-dependent manner in immunemediated diabetes induced by multiple low-doses of streptozotocin (MLDS). The extract at the concentration of 400 mg/kg exhibited high inhibition of diabetes incidence by 15%.…”

Section: Antidiabetic Activitiesmentioning

confidence: 99%

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Zhang

Zhao

et al. 2015

Journal of Ethnopharmacology

155

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Section: Antidiabetic Activitiesmentioning

confidence: 99%

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Zhang

Zhao

et al. 2015

Journal of Ethnopharmacology

155

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“…Based on the phenotypic analysis the groups treated with higher doses (100-400 mg/kg) showed CD4(+) and CD8(+) T-cell values similar to those observed in healthy animals. The proportion of CD4(+)CD25(+)Foxp3(+) regulatory T-cells were also increased by these same higher doses (26).…”

Section: Uncaria Tomentosamentioning

confidence: 82%

A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

Mahmoudian-Sani¹,

Asadi-Samani²,

Luther³

et al. 2017

J Renal Inj Prev

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“…Studies show that C. guianensis (andiroba) oil has anti-inflammatory [35, 95], antiparasitic [96], antispasmodic [97], repellent, antiallergic, antirheumatic and healing properties [98]. Pharmacological tests performed in vitro and in vivo with U. tomentosa (jupindá) showed antioxidant [99], anticancer [100], anti-inflammatory [101], antimicrobial [102], antiherpetic [103] and antidiabetic [104] activities. In turn, Pentaclethra macroloba, Virola surinamensis , Dalbergia monetaria , Otacanthus azureus , Virola surinamensis , Hura crepitans, and Euterpe oleracea are little known pharmacologically.…”

Section: Resultsmentioning

confidence: 99%

The Use of Medicinal Plants in the Riverside Community of the Mazagão River in the Brazilian Amazon, Amapá, Brazil: Ethnobotanical and Ethnopharmacological Studies

Sarquis

Sarquis³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The inhabitants of the floodplain of the Mazagão River in the State of Amapá in the Brazilian Amazon have inherited from indigenous African and Cabocla cultures indications for the use and forms of preparation of medicinal plants to cure diseases of the body and spirit. This study aimed to perform an ethnopharmacological survey of medicinal plants used by the riparian community of the floodplains of the Mazagão River, in the State of Amapá. In this study, we chose semistructured interviews with socioeconomic, ethnopharmacological, and ethnobotanical aims. The collection of medicinal plants occurred during guided tours. The Use Value (UV), Informant Consensus Factor (ICF), Correction Factor (CF), and Fidelity level (FL) were calculated. There were 130 species of medicinal plants, distributed in 116 genera and 57 families; Fabaceae (16), Lamiaceae (14), Euphorbiaceae (7), and Arecaceae (6) include 33.33% of the total species sampled. All 95 native species of floodplain forests were previously described, and 35 are exotic species. The species with the highest UV (≥ 0.5) at the mouth of the Mazagão River were Carapa guianensis (0.91), Pentachlethra macroloba (0.83), Dalbergia subcymosa (0.77), Uncaria tomentosa (0.75), Otacanthus azureus (0.62), Virola surinamensis (0.62), Hura crepitans (0.58), Euterpe oleracea (0.56), and Arrabidaea chica (0.51). These species were also the ones that presented the highest ICF among the informants and 100% in FL for a specific therapeutic use. The study is comprised of 16 categories of therapeutic use, of which the majority of the plants used are related to diseases such as microbial infections (20.67%, 73 species), gastrointestinal disorders (13.31%), and inflammation (11.61%). The results showed that knowledge about the use of medicinal plants along the rivers and streams that form the mouth of the Mazagão River is evenly distributed. Most of the interviewees present diversified knowledge about the medicinal resources because they have a close relationship with the floodplain forest. Native species of this forest predominate among the most commonly used medicinal plants as subsidies for future pharmacological studies.

show abstract

Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?

Abstract: The extract was effective to prevent the progression of immune-mediated diabetes by distinct pathways.

Cited by 22 publications

References 58 publications

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

The Use of Medicinal Plants in the Riverside Community of the Mazagão River in the Brazilian Amazon, Amapá, Brazil: Ethnobotanical and Ethnopharmacological Studies

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