A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

Mahmoudian-Sani, Mohammad Reza; Asadi-Samani, Majid; Luther, Tahra; Saeedi-Boroujeni, Ali; Gholamian, Neda

doi:10.15171/jrip.2017.31

Cited by 19 publications

(11 citation statements)

References 40 publications

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“…There has been great advancement in the field of phytotherapy, with marked increased in the use of medicinal plants such as curcumin as phytotherapeutics due to its pharmacological safety and antioxidant properties against heavy metal poisoning [12,13,14,15]. Chelation therapy is a recommended strategy in the treatment and management of chronic Pb poisoning, however, the major limiting factor regarding chelation therapy is some chelating agents could have a nonspecific action, resulting in the removal of essential metals from the body [16,17].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress

et al. 2019

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Lead (Pb) is a toxic, environmental heavy metal that induces serious clinical defects in all organs, with the nervous system being its primary target. Curcumin is the main active constituent of turmeric rhizome (Curcuma longa) with strong antioxidant and anti-inflammatory properties. This study is aimed at evaluating the therapeutic potentials of curcumin on Pb-induced neurotoxicity. Thirty-six male Sprague Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and 6 rats in each of groups, i.e., the lead-treated group (LTG) (50 mg/kg lead acetate for four weeks), recovery group (RC) (50 mg/kg lead acetate for four weeks), treatment group 1 (Cur100) (50 mg/kg lead acetate for four weeks, followed by 100 mg/kg curcumin for four weeks) and treatment group 2 (Cur200) (50 mg/kg lead acetate for four weeks, followed by 200 mg/kg curcumin for four weeks). All experimental groups received oral treatment via orogastric tube on alternate days. Motor function was assessed using a horizontal bar method. The cerebellar concentration of Pb was evaluated using ICP-MS technique. Pb-administered rats showed a significant decrease in motor scores and Superoxide Dismutase (SOD) activity with increased Malondialdehyde (MDA) levels. In addition, a marked increase in cerebellar Pb concentration and alterations in the histological architecture of the cerebellar cortex layers were recorded. However, treatment with curcumin improved the motor score, reduced Pb concentration in the cerebellum, and ameliorated the markers of oxidative stress, as well as restored the histological architecture of the cerebellum. The results of this study suggest that curcumin attenuates Pb-induced neurotoxicity via inhibition of oxidative stress and chelating activity.

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Section: Introductionmentioning

confidence: 99%

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress

et al. 2019

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“…Other health effects include the improvement in function of large bowel and modulation of fecal microflora [207], beneficial effects in gastrointestinal function [208] and cognitive ability [209,210], and the activation of the immune system [211]. The root color of purple yam (D. alata) is attributed to the high content of anthocyanins which exhibit significant antibacterial activities [212], anti-inflammatory effects on trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice [213], antiglycative properties [214], and antidiabetic properties [215,216]. The main detected anthocyanins in this species were identified as cyanidin, pelargonidin, and peonidin-type compounds and alatanins A-C [43]; however, the individual compound profile and the overall anthocyanin content are affected by maturity stage and the expression of the concomitant genes [44].…”

Section: Yammentioning

confidence: 99%

Grown to be Blue—Antioxidant Properties and Health Effects of Colored Vegetables. Part I: Root Vegetables

et al. 2019

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During the last few decades, the food and beverage industry faced increasing demand for the design of new functional food products free of synthetic compounds and artificial additives. Anthocyanins are widely used as natural colorants in various food products to replenish blue color losses during processing and to add blue color to colorless products, while other compounds such as carotenoids and betalains are considered as good sources of other shades. Root vegetables are well known for their broad palette of colors, and some species, such as black carrot and beet root, are already widely used as sources of natural colorants in the food and drug industry. Ongoing research aims at identifying alternative vegetable sources with diverse functional and structural features imparting beneficial effects onto human health. The current review provides a systematic description of colored root vegetables based on their belowground edible parts, and it highlights species and/or cultivars that present atypical colors, especially those containing pigment compounds responsible for hues of blue color. Finally, the main health effects and antioxidant properties associated with the presence of coloring compounds are presented, as well as the effects that processing treatments may have on chemical composition and coloring compounds in particular.

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“…In this regard, there has been a renewed interest in the approaches of traditional medicine and phytotherapy in medical arena. Medicinal plants and their derivatives have been studied, by the application of scientific approaches, in vitro, with animals, and ultimately in clinical trials so that more efficient therapeutic approaches and drugs can be discovered [16][17][18][19][20][21][22][23][24][25][26] . Apart from drug therapy, other methods are used in tinnitus therapy such as phytotherapy (Table 2).…”

Section: Medicinal Plants and Tinnitusmentioning

confidence: 99%

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Mahmoudian-Sani¹,

Hashemzadeh‐Chaleshtori²,

Asadi-Samani³

et al. 2017

The International Tinnitus Journal

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Introduction: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical-psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus. Evidence Acquisitions: Google Scholar, Directory of Open Access Journals (DOAJ), PubMed, LISTA (EBSCO) and Web of Science have been searched. Results: There are many studies on the therapeutic effect of Ginkgo biloba on patients with tinnitus. Most findings are in contrast with each other so that some of studies reported that Ginkgo biloba is effective in the treatment of tinnitus and other studies referred to it as ineffective herbal medicine. Generally, according to the previous studies and the present study, it can mention that the Ginkgo biloba may somewhat improve tinnitus. Conclusion: Since tinnitus is multifactorial, it is recommended to evaluate patients individually based on the cause of tinnitus, treatment formulas, and different doses of Ginkgo biloba at the more extensive level in future studies.

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A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

Cited by 19 publications

References 40 publications

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress

Grown to be Blue—Antioxidant Properties and Health Effects of Colored Vegetables. Part I: Root Vegetables

Ginkgo biloba in the treatment of tinnitus: An updated literature review

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