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Cited by 69 publications
(51 citation statements)
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“…The specific area of vessels with signs of partial occlusion of retinal vessels is significantly greater in young OXYS rats compared with Wistar rats. 32,33 Overall, the changes in the chorioretinal complex of OXYS rats 64,65 reflected a typical reaction to chronic hypoxia, one of the leading factors in the pathogenesis of AMD.…”
Section: Signs Of Neurodegeneration In Oxys Ratsmentioning
confidence: 99%
See 1 more Smart Citation
“…The specific area of vessels with signs of partial occlusion of retinal vessels is significantly greater in young OXYS rats compared with Wistar rats. 32,33 Overall, the changes in the chorioretinal complex of OXYS rats 64,65 reflected a typical reaction to chronic hypoxia, one of the leading factors in the pathogenesis of AMD.…”
Section: Signs Of Neurodegeneration In Oxys Ratsmentioning
confidence: 99%
“…At present, we have the 102nd generation of OXYS rats with spontaneously developing cataract and accelerated senescence syndrome, which is characterized by early development of a phenotype similar to human geriatric disorders. This pathological phenotype primarily includes accelerated thymus involution, [28][29][30] retinopathy similar to human AMD, [31][32][33][34] high blood pressure, 35 and senile osteoporosis. 36-38 Accelerated brain aging manifests itself in OXYS rats as early development of behavioral and cognitive alterations against the background of neurodegenerative changes driven by an AD-like metabolic pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Just as the dry form of human AMD, the initial alterations in the RPE cells later lead to atrophy of the choriocapillaris and the complete loss of photoreceptor cells in the OXYS rats' retinas by the age of 24 months. 12,14,15 Previously, by means of RNA sequencing (RNA-Seq), we determined that the retinopathy in OXYS rats at the first stage (age 3 months) and second stage (age 18 months) develops simultaneously with changes in mRNA levels of hundreds of genes. Most of them are linked to immune responses, inflammation, the response to oxidative stress, Ca 2C homeostasis, and apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13][14][15][16] OXYS rats develop retinopathy similar to the dry form of human AMD according to the clinical signs, morphological features, and some molecular changes. In these rats, the clinical signs of retinopathy appear by the age of 3 months during a reduction in the transverse area of the RPE and impairment of choroidal microcirculation.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Furthermore, mTOR has emerged as a potential target for therapies for age-related diseases such as cardiac hypertrophy, 3 cancer, 4,5 age-related macular degeneration, 6 and neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington. 7 Rapamycin suppresses accelerated, 8 physiological, 9,10 and oncogene-induced 11,12 senescence in human and rodent cells, which may explain anti-aging effects seen in mammals.…”
Section: Introductionmentioning
confidence: 99%