Prevalencia del síndrome metabólico en Argentina en los últimos 25 años: revisión sistemática de estudios observacionales poblacionales

Diaz, Alberto Alejandro; Espeche, Walter G; March, Christine; Flores, R.; Parodi, R; Genesio, M. A.; Sabio, Rodrigo; Poppe, S.

doi:10.1016/j.hipert.2017.08.003

Cited by 18 publications

(18 citation statements)

References 17 publications

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“…No standardized global data are available on the prevalence of MetS because diagnostic criteria vary in different guidelines [ 1 ]. In Argentina, a systematic review carried out with urban populations, with a mean age of 46.2, found a prevalence of MetS of 27.5% for both genders, higher in males than females, at 29.4% vs. 27.4% respectively [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

et al. 2020

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Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL®), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.

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Section: Introductionmentioning

confidence: 99%

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

et al. 2020

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“… 24 In fact, the metabolic syndrome prevalence has continuously increased from 20% and 21% in 2008 25 to 25% in 2011 26 and between 27.5% and 34.1% in 2016. 27 , 28 This acceleration in the frequency of metabolic alterations has triggered morbidity and mortality caused by cardiovascular diseases, which represent the leading disability and death among adults. 29 …”

Section: Introductionmentioning

confidence: 99%

A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Mora-García

Gómez‐Camargo

Alario

et al. 2018

Metabolic Syndrome and Related Disorders

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Background: The caveolin 1 (CAV1) gene has been associated with metabolic traits in animal models and human cohorts. Recently, a prevalent variant in CAV1 has been found to be related to metabolic syndrome in Hispanics living in North America. Since Hispanics represent an admixed population at high risk for cardiovascular diseases, in this study a Latin American population with a similar genetic background was assessed.Objective: To analyze a genetic association between CAV1 and metabolic traits in an admixed Latin American population.Methods: A cross-sectional study was carried out with adults from the Colombian Caribbean Coast, selected in urban clusters and work places through a stratified sampling to include diverse ages and socioeconomic groups. Blood pressure and waist circumference were registered. Serum concentrations of glucose, triglycerides, and high-density lipoprotein cholesterol were measured from an 8-hr fasting whole-blood sample. Two previously analyzed CAV1 single nucleotide polymorphisms were genotyped (rs926198 and rs11773845). A logistic regression model was applied to estimate the associations. An admixture adjustment was performed through a Bayesian model.Results: A total of 605 subjects were included. rs11773845 was associated with hypertriglyceridemia [odds ratio (OR) = 1.33, p = 0.001] and the metabolic syndrome (OR = 1.53, p = 0.02). When admixture adjustment was performed these genetic associations preserved their statistical significance. There were no significant associations between rs926198 and metabolic traits.Conclusions: The CAV1 variation rs11773845 was found to be consistently associated with high serum triglycerides and the metabolic syndrome. This is the first report of a relationship between CAV1 variants and serum triglycerides in Latin America.

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“…Además, fue notorio cómo, a medida que aumenta la severidad de la AOS, disminuye el porcentaje de pacientes con normo peso y aumenta el de pacientes con sobrepeso o algún grado de obesidad, datos coincidentes con la literatura 2,10,25 . Al carecer de un grupo de pacientes control o de datos epidemiológicos que informen la frecuencia de factores de RCV en la población general, comparamos nuestros resultados con una muestra de pacientes estudiada en una revisión sistemática sobre estudios de Argentina entre enero de 1988 y diciembre de 2014 por el Grupo de Trabajo en Epidemiología de la Sociedad Argentina de Hipertensión Arterial y el CONICET 26 , que probablemente refleje una aproximación a la epidemiología de nuestro país. En dicho estudio, el 38,8% de los pacientes fueron dislipémicos, el 33,4% hipertensos, el 32,1% obesos y el 7,5% diabéticos.…”

Section: Discussionunclassified

Frecuencia de factores de riesgo cardiovascular en pacientes con síndrome de apnea obstructiva del sueño

Gallmann¹,

Camporro²,

Gazzoni³

2020

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INTRODUCCIÓN: La apnea obstructiva del sueño afecta al 14% de los hombres y al 5% de las mujeres.Diversos estudios han demostrado la asociación entre el síndrome de apnea obstructiva del sueño (SAOS)y enfermedades cardiovasculares. Los pacientes con SAOS tienen aproximadamente cinco vecesmás riesgo de desarrollar enfermedad cardiovascular a siete años.OBJETIVO: Estimar la frecuencia de factores de riesgo cardiovascular en una muestra de pacientes conApnea Obstructiva del Sueño (AOS).PACIENTES Y MÉTODOS Se realizó un estudio observacional, transversal, descriptivo. Se incluyeronpacientes consecutivos mayores de 18 años diagnosticados con SAOS en el laboratorio de sueño de laClínica Universitaria Reina Fabiola, durante el periodo comprendido entre el entre el 1 de junio de 2018 y30 dediciembre de 2018. Se registraron las siguientes variables: edad, sexo, índice de masa corporal (IMC),hipertensión arterial (HTA), hábito tabáquico, diabetes, dislipemia, enfermedad cardiovascularaterosclerótica clínica y evaluación del riesgo cardiovascular (RCV) a 10 años calculado a través delCardiovascular Risk Calculator PAHO/WHO. Se realizó una descripción de las variables cuantitativasmediante medidas de posición y dispersión. Las variables cualitativas se expresaron en porcentajes.RESULTADOS: Se incluyeron 99 pacientes. El 79,8% fueron hombres, con una media (desviaciónestándar, DE) de edad de 44,84±13,55 años y el 20,20% fueron mujeres, con una media (DE) de edad de46,15±11,54 años.El principal factor de riesgo cardiovascular (RCV) encontrado fue dislipemia (77,78%), seguido de HTA(38,38%) y obesidad (56,56%) o sobrepeso (34,34%). El 64,27% de los pacientes con AOS leve, el 84%de los pacientes con AOS moderada y el 95% de los pacientes con AOS grave, tuvieron dos o más factoresde RCV.Al calcular el RCV global a 10 años, el 91,92% de los pacientes tuvieron un RCV bajo, el 2,02% moderadoy el 6,06% muy alto. Ningún paciente tuvo RCV alto. El 87,88% de los pacientes teníandos o más factores de RCVCONCLUSIONES: Destacamos la relación, ya descrita en la literatura, entre los factores de RCV y la AOS.La misma fue más notoria al observar la cantidad de pacientes que además de AOS presentaron HTA,diabetes y obesidad, condiciones altamente prevalentes en nuestra sociedad. La mayoría de los pacientescon AOS presentó dos o más factores de RCV.

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Prevalencia del síndrome metabólico en Argentina en los últimos 25 años: revisión sistemática de estudios observacionales poblacionales

Cited by 18 publications

References 17 publications

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Frecuencia de factores de riesgo cardiovascular en pacientes con síndrome de apnea obstructiva del sueño

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