Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Pastor, Raúl; Repetto, Marisa G.; Lairion, Fabiana; Lazarowski, Alberto; Merelli, Amalia; Carabetti, Zulma Manfredi; Pastor, Isabel; Pastor, Elena; Iermoli, Laura Valeria; Bavasso, Carlos Amadeo; Iermoli, Roberto

doi:10.3390/nu12103149

Cited by 15 publications

(15 citation statements)

References 44 publications

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“…Our study reported only 2% of obese mothers suffered from early neonatal death (END). Mitanchez and Pascale, agreed with our study that Maternal obesity alone increased the risks for adverse neonatal outcomes, including macrosomia, perinatal mortality, induced preterm birth and birth defects [28].…”

Section: Discussionsupporting

confidence: 89%

Maternal Obesity and Its Adverse Effect on Maternal and Fetal Health

Lutfy

Dawood

Gergawy

et al. 2021

JAMMR

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Background: The increasing prevalence of obesity worldwide has prompted the World Health Organization (WHO) to designate obesity as one of the most important global health threats. The epidemic is especially pronounced in women of reproductive age. Prepregnancy obesity is an independent risk factor for maternal and neonatal morbidity and mortality. The origin of this epidemic is unhealthy lifestyle – high energy and high-fat diet and physical inactivity. During periconceptual period and pregnancy, the composition of a woman’s diet is of particular importance, as it may influence the pregnancy, the delivery and the health of the mother and the infant later on, so an excessive gestational weight gain (GWG) is not recommended. The aim of our study is to clarify the complications related to excess prepregnancy body weight on maternal and fetal health. Methods: Hundred obese pregnant women with BMI (30-40 Kg/m2) measured at first trimester were prospectively enrolled into this study. Routine blood pressures, random blood sugar measuring and ultrasonographic follow up are required during pregnancy for early detection of any complications related to maternal obesity and excessive gestational weight gain (GWG). Results: cases statistically evaluated in these study were 100 pregnant females with mean age 27.34 years + 5 years SD and mean BMI 32.97 Kg/m2 + 2.92 Kg/m2 SD. Denoting in our study, the effect of maternal obesity om maternal and fetal health. Conclusion: A causal relationship between the prepregnancy BMI and obstetric complications is proven. Weight management is important for every women of reproductive age. Thus, medical Practice must consider these complications by providing early detection and management to improve both maternal and neonatal outcome.

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Section: Discussionsupporting

confidence: 89%

Maternal Obesity and Its Adverse Effect on Maternal and Fetal Health

Lutfy

Dawood

Gergawy

et al. 2021

JAMMR

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“…Since both the oxidative stress and inflammation plays important role in the pathophysiology of MetS (46), the negative relationship between dietary vitamin E level and MetS may be mainly attributed to the antioxidant and anti-inflammatory property of vitamin E (12,47,48). Consistently, the clinical trial evidence demonstrates that the vitamin E supplementation may ameliorate MetS via anti-inflammation and anti-oxidative stress (49,50). Moreover, some experimental animal studies have also indicated the beneficial impact of vitamin E intake on the MetS-related context (13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 82%

Associations of Dietary and Circulating Vitamin E Level With Metabolic Syndrome. A Meta-Analysis of Observational Studies

et al. 2021

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Objective: The associations of dietary and circulating vitamin E level with metabolic syndrome (MetS) remains conflicting. This meta-analysis of observational study was therefore employed to investigate the issue above.Methods: The PubMed, Web of Science and Embase database were searched up to April 2021. The observational studies on the associations of dietary and circulating vitamin E level with MetS were specified. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary and circulating vitamin E level, and the standard mean difference (SMD) of dietary and circulating vitamin E level for MetS vs. control subjects, were calculated.Results: A total of 25 observational studies with 51,276 participants, were included in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary vitamin E level was inversely associated with MetS (RR = 0.92, 95%CI: 0.85–1.00; P = 0.044). In addition, the dietary vitamin E level in MetS was also lower than that in control subjects according to the overall combined SMD (SMD = −0.08, 95%CI: −0.14 to −0.02; P = 0.024). On the other hand, the overall multi-variable adjusted RR showed no significant relationship between the circulating vitamin E level and MetS (RR = 1.46, 95%CI: 0.85–2.48; P = 0.17). However, the circulating vitamin E level in MetS was lower than that in control subjects according to the overall combined SMD (SMD = −0.58, 95%CI: −1.04 to −0.13; P = 0.013).Conclusions: The results of this meta-analysis suggest that the dietary vitamin E level is inversely associated with MetS. On the other hand, current evidence is still insufficient to conclude a relationship between the circulating vitamin E level and MetS. More well-designed prospective cohort studies are needed to address the issues further.

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“…In a recent clinical trial, older adults (13 males and 9 females) diagnosed with metabolic syndrome and on concurrent therapeutics to treat their conditions were provided with supplements containing RES + PIP + α-tocopherol (FRAMINTROL ® ) [ 37 ]. Over the course of three months, the subjects were evaluated for the inflammatory state by tracking C-reactive protein (CRP), an inflammatory marker, ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils.…”

Section: Current Research Supporting Phytochemical Use In Various Chr...mentioning

confidence: 99%

Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases

et al. 2022

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Chronic inflammatory diseases occur in a large portion of the population and are associated with a poor diet. Key natural products found in fruits and vegetables may assist in lowering inflammation associated with chronic diseases such as obesity, diabetes, cardiovascular diseases, and cancer. This review seeks to examine the roles of several natural products, resveratrol (RES), quercetin (QUE), curcumin (CUR), piperine (PIP), epigallocatechin gallate (EGCG), and gingerol (GIN), in their ability to attenuate inflammatory markers in specific diseases states. Additionally, we will discuss findings in past and ongoing clinical trials, detail possible phytochemical–drug interactions, and provide a brief resource for researchers and healthcare professionals on natural product and supplement regulation as well as names of databases with information on efficacy, indications, and natural product–drug interactions. As diet and over-the-counter supplement use are modifiable factors and patients are interested in using complementary and alternative therapies, understanding the mechanisms by which natural products have demonstrated efficacy and the types of drugs they interact with and knowing where to find information on herbs and supplements is important for practicing healthcare providers and researchers interested in this field.

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Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Cited by 15 publications

References 44 publications

Maternal Obesity and Its Adverse Effect on Maternal and Fetal Health

Maternal Obesity and Its Adverse Effect on Maternal and Fetal Health

Associations of Dietary and Circulating Vitamin E Level With Metabolic Syndrome. A Meta-Analysis of Observational Studies

Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases

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