Prevalência de subtipos do HIV-1 em amostra de pacientes de um centro urbano no sul do Brasil

Simon, Daniel; Béria, Jorge Umberto; Tietzmann, Daniela Cardoso; Carli, Rafaela de; Stein, Airton Tetelbom; Lunge, Vagner Ricardo

doi:10.1590/s0034-89102010005000039

Cited by 12 publications

(13 citation statements)

References 22 publications

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“…The patients' age ranged between 15 and 79 years, and the most prevalent age range was between 30 and 39 years, with 74 (34.4%) people, followed by the group between 40 and 49 years with 69 (32.1%) people. Similar data were found in other studies, showing that there are more HIV patients among young adults of reproductive age, between 15 and 49 years 6,7 . As regards the sexual orientation, most participants, 139 (64.7%), characterized themselves as heterosexual.…”

Section: Resultssupporting

confidence: 91%

“…Although the feminization of HIV is a known phenomenon, the data confirm studies in other Brazilian regions, in which male patients are predominant 6,7 . The patients' age ranged between 15 and 79 years, and the most prevalent age range was between 30 and 39 years, with 74 (34.4%) people, followed by the group between 40 and 49 years with 69 (32.1%) people.…”

Section: Resultssupporting

confidence: 82%

“…As regards the sexual orientation, most participants, 139 (64.7%), characterized themselves as heterosexual. This finding relates to the fact that, nowadays, the heterosexualization of the epidemic has significantly increased, as evidenced in the literature 6,7 . As regards the years of education, 86 (40%) patients possess between 11 and 15 years of education, followed by 67 (31.2%) with six to ten years of education.…”

Section: Resultsmentioning

confidence: 75%

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Adherence to antiretroviral treatment: comprehensive care based on the care model for chronic conditions

Fiuza¹,

Lopes²,

Alexandre³

et al. 2013

Escola Anna Nery - Revista De Enfermagem

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Objective: To evaluate the adherence to antiretroviral therapy (ART), identifying possible interventions based on the Care Model for Chronic Conditions. Methods: Observational, quantitative, cross-sectional study, involving 215 people with HIV/aids using antiretroviral drugs, between March and June 2012, in Fortaleza, Ceará. From the specific adherence questionnaire, we used nine questions for discussion in the light of the Care Model for Chronic Conditions (MACC). Results: 35.4% failed to adhere to medication at least once. In view of the MACC, gaps were identified, such as the need for more professional intervention, showing possibilities to apply new strategies, such as self-care actions, motivational interviews, operative group and others. Conclusion: A significant percentage of non-adherence to ART was found, whose interventions are still incipient. Actions based on the MACC can favor comprehensive care for patients with HIV/aids. RESUMOO objetivo deste estudo foi avaliar a adesão à terapia antirretroviral (TARV), identificando possibilidades de intervenções embasadas no modelo de atenção às condições crônicas. Métodos: Estudo observacional, quantitativo, transversal, desenvolvido com 215 pessoas com HIV/AIDS em uso de antirretrovirais, entre março e junho de 2012, em Fortaleza, Ceará. De um questionário específico para avaliar a adesão utilizaram-se nove quesitos para discussão à luz do Modelo de Atenção às Condições Crônicas (MACC). Resultados: 35,4% das pessoas estudadas deixaram de aderir ao tratamento pelo menos alguma vez, por se sentirem melhor/ pior, ou tristes/deprimidas. Sob a luz do MACC, foram identificadas lacunas, como necessidade de mais intervenção profissional, evidenciando possibilidades de aplicar novas estratégias, como ações para o autocuidado, entrevista motivacional, grupo operativo,e outras. Conclusão: Constatou-se que há um percentual significativo de não adesão à TARV, cujas intervenções ainda são incipientes,e que ações baseadas no MACC podem favorecer uma assistência totalitária aos pacientes com HIV/AIDS. RESUMENObjetivo: Evaluar la adherencia a la terapia antirretroviral (TARV), identificando las posibles intervenciones basadas en el modelo de atención de las condiciones crónicas. Métodos: Estudio observacional, cuantitativo, transversal, desarrollado con 215 personas con VIH/SIDA con medicamentos antirretrovirales, entre marzo y junio de 2012, en Fortaleza, Ceará. De un cuestionario específico para valorar la adherencia, se utilizaron nueve preguntas para su discusión a la luz del Modelo de Atención a las Condiciones Crónicas (MACC). Resultados: Se observó que 35,4% de los pacientes dejaron de adherir a la medicación por lo menos una vez. A la luz del MACC, fueron identificadas deficiencias, como la necesidad de más intervención profesional, mostrando las posibilidades de implementar nuevas estrategias, como las acciones de autocuidado, entrevista motivacional, grupo operativo y otros. Conclusión: Se encontró un porcentaje significativo de no adherencia al tratamiento...

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 75%

See 1 more Smart Citation

Adherence to antiretroviral treatment: comprehensive care based on the care model for chronic conditions

Fiuza¹,

Lopes²,

Alexandre³

et al. 2013

Escola Anna Nery - Revista De Enfermagem

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“…1), where the CRF31_BC frequency is around 22% and may reach 35% in the metropolitan region (34,40). Despite the more pronounced occurrence in Porto Alegre and nearby cities, CRF31_BC is not limited to this region, as it was also observed in more distant locations in the present study.…”

Section: Discussioncontrasting

confidence: 48%

Comprehensive Characterization of HIV-1 Molecular Epidemiology and Demographic History in the Brazilian Region Most Heavily Affected by AIDS

Gräf

Fritsch

Medeiros

et al. 2016

J Virol

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The high incidence of AIDS cases and the dominance of HIV-1 subtype C infections are two features that distinguish the HIV-1 epidemic in the two southernmost Brazilian states (Rio Grande do Sul [RS] and Santa Catarina [SC]) from the epidemic in other parts of the country. Nevertheless, previous studies on HIV molecular epidemiology were conducted mainly in capital cities, and a more comprehensive understanding of factors driving this unique epidemic in Brazil is necessary. Blood samples were collected from individuals in 13 municipalities in the Brazilian southern region. HIV-1 env and pol genes were submitted to phylogenetic analyses for assignment of subtype, and viral population phylodynamics were reconstructed by applying Skygrid and logistic coalescent models in a Bayesian analysis. A high prevalence of subtype C was observed in all sampled locations; however, an increased frequency of recombinant strains was found in RS, with evidence for new circulating forms (CRFs). In the SC state, subtype B and C epidemics were associated with distinct exposure groups. Although logistic models estimated similar growth rates for HIV-1 subtype C (HIV-1C) and HIV-1B, a Skygrid plot reveals that the former epidemic has been expanding for a longer time. Our results highlight a consistent expansion of HIV-1C in south Brazil, and we also discuss how heterosexual and men who have sex with men (MSM) transmission chains might have impacted the current prevalence of HIV-1 subtypes in this region. IMPORTANCEThe AIDS epidemic in south Brazil is expanding rapidly, but the circumstances driving this condition are not well known. A high prevalence of HIV-1 subtype C was reported in the capital cities of this region, in contrast to the subtype B dominance in the rest of the country. This study sought to comparatively investigate the HIV-1 subtype B and C epidemics by sampling individuals from several cities in the two states with the highest AIDS incidences in Brazil. Our analyses showed distinct epidemic growth curves for the two epidemics, and we also found evidence suggesting that separate transmission chains may be impacting the viral phylodynamics and the emergence of new recombinant forms. High-level molecular diversity is one of the main features of HIV-1. Due to the very high replication rate and the lack of a proofreading activity of the viral reverse transcriptase (RT) enzyme, HIV-1 group M, the pandemic strain, has evolved into a diverse number of variants (1). Among 9 HIV-1 group M subtypes, HIV-1 subtype C (HIV-1C) is responsible for Ͼ50% of infections worldwide, occurring mostly in southern and east African countries and India. HIV-1B, in turn, is widely dispersed throughout the world, being the dominant strain in Europe and in the Americas, but with a worldwide prevalence of only 10% (1, 2). The high level of variability of HIV-1 is also a consequence of the genetic recombination process, which can occur in unique recombinant forms (URFs), when fewer than three individuals are infected, or in circulating forms (C...

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“…2 A epidemia da AIDS no Rio Grande do Norte tem como característica predominante a transmissão sexual, indicando uma heterossexualização da epidemia, que pode ser evidenciada em vários estudos. [9][10][11] Apesar do evidente avanço da doença entre os indivíduos heterossexuais, estudo internacional aponta elevada prevalência da infecção pelo HIV entre homens que fazem sexo com outros homens e transexuais (10,6% e 17,7% respectivamente) em comparação à população geral (entre 0,4% a 1%). 1 Apesar de ainda haver mais casos de AIDS entre os homens do que entre as mulheres, essa diferença tem diminuído ao longo dos anos, indicando o avanço do processo de feminização do HIV, no qual o número de mulheres infectadas aumenta rapidamente entre as heterossexuais casadas, com parceiro único e não-usuárias de drogas, sendo a relação sexual a principal via de transmissão do HIV para essas mulheres.…”

Section: Discussionunclassified

Perfil dos casos de Síndrome da Imunodeficiência Adquirida em um estado do nordeste do Brasil

Silva

Silva²,

Salvetti

et al. 2015

Rev Enferm UFSM

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Prevalência de subtipos do HIV-1 em amostra de pacientes de um centro urbano no sul do Brasil

Cited by 12 publications

References 22 publications

Adherence to antiretroviral treatment: comprehensive care based on the care model for chronic conditions

Adherence to antiretroviral treatment: comprehensive care based on the care model for chronic conditions

Comprehensive Characterization of HIV-1 Molecular Epidemiology and Demographic History in the Brazilian Region Most Heavily Affected by AIDS

Perfil dos casos de Síndrome da Imunodeficiência Adquirida em um estado do nordeste do Brasil

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