Prevalence, risk factors, and impact of lung Cancer on outcomes of idiopathic pulmonary fibrosis: a study from the Middle East

Salim, Mohamed; Bayoumi, Hassan; El‐Aziz, Nashwa Abd; Mousa, Ehab; Gamal, Yasser

doi:10.1186/s40248-018-0150-7

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…This is of particular importance because almost all chronic respiratory disorders affect -in a way or another- the lung mechanics and/or the ventilatory control [ 20 ], so the preparation for weaning a patient with chronic respiratory disorder is of crucial importance and represents a challenging task for the pulmonologist and/or the intensivist. This task will be harder in patients with combined respiratory disorders (e.g., overlap syndrome, obesity hypoventilation syndrome) [ 9 , 20 , 21 ]. Our study included considerable numbers of patients with different respiratory disorders.…”

Section: Discussionmentioning

confidence: 99%

Value of modified Burns Wean Assessment Program scores in the respiratory intensive care unit: An Egyptian study

Abdelaleem¹,

Salim²,

ElHafeez

et al. 2020

Multidis Res Med

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Background: There is no consensus on the most useful predictive indicator for weaning patients from mechanical ventilation (MV). We aimed to evaluate the utility of the modified Burns Wean Assessment Program (m-BWAP) in predicting the weaning success in patients with respiratory disorders admitted to the respiratory intensive care unit (RICU).Methods: Patients with respiratory failure requiring MV for longer than 48 hours were included. They were weaned by pressure support ventilation and spontaneous breathing trails. Patients were divided into successful and unsuccessful weaning groups according to their outcomes.Results: A total of 91 patients were enrolled. The majority had chronic obstructive pulmonary diseases (COPD); 40%, overlap syndrome (24%), and obesity hypoventilation syndrome (OHS): 15%. The successful group had significantly higher m-BWAP scores than that in the unsuccessful group (median 65; range 35 to 80 vs median 45; range 30 to 65; p=0.000), with area under the curve (AUC) of 0.854; 95% CI 0.766 to 0.919), p<0.001. At cut-off value of ≥55, the sensitivity and specificity of m-BWAP to predict successful weaning were 73.77% and 84.85%, respectively. The AUC for m-BWAP was significantly higher than that for rapid shallow breathing index (RSBI).Conclusion: We conclude that m-BWAP scores represent a good predictor of weaning success among patient with chronic respiratory disorders in the RICU. The m-BWAP checklist has many factors that are closely related to the weaning outcomes of patients with chronic respiratory disorders. Further, large-scale, multicenter studies are warrented.

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Section: Discussionmentioning

confidence: 99%

Value of modified Burns Wean Assessment Program scores in the respiratory intensive care unit: An Egyptian study

Abdelaleem¹,

Salim²,

ElHafeez

et al. 2020

Multidis Res Med

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“…However, most lung cancer patients are diagnosed at an advanced stage, and their 5-year survival rate is only 19.7%, that is to say, they missed the best treatment opportunity [ 1 , 3 ]. Most studies have suggested that the occurrence of lung cancer is related to environmental factors, such as smoking, occupational exposure, and air pollution [ 4 , 5 ]. At the same, genetic factors play an important role in the development of lung cancer, including EGFR [ 6 ], CHRNA5 [ 7 ], CLPTM1L [ 8 ], TP63 [ 9 ], and so on.…”

Section: Introductionmentioning

confidence: 99%

Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

Geng

Chen

et al. 2022

BMC Cancer

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Background Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer. Methods Five SNPs in GTF2H1 and four SNPs in RAD54L2 in 506 patients with lung cancer and 510 age-and gender-matched healthy controls were genotyped via the Agena MassARRAY platform. The influence of GTF2H1 and RAD54L2 polymorphisms on lung cancer susceptibility was assessed using logistic regression analysis by calculating odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Results RAD54L2 rs9864693 GC genotype increased the risk of lung cancer (OR = 1.33, 95%CI: 1.01–1.77, p = 0.045). Stratified analysis found that associations of RAD54L2 rs11720298, RAD54L2 rs4687592, RAD54L2 rs9864693 and GTF2H1 rs4150667 with lung cancer risk were found in subjects aged ≤ 59 years. Precisely, a protective effect of RAD54L2 rs11720298 on the occurrence of lung cancer was observed in non-smokers and drinkers. GTF2H1 rs4150667 was associated with a decreased risk of lung cancer in subjects with BMI ≤ 24 kg/m2. RAD54L2 rs4687592 was associated with an increased risk of lung cancer in drinkers. In addition, GTF2H1 rs3802967 was associated with a reduced risk of lung squamous cell carcinoma. Conclusion Our study first revealed that RAD54L2 rs9864693 was associated with an increased risk of lung cancer in the Chinese Han population. This study may increase the understanding of the effect of RAD54L2 and GTF2H1 polymorphisms on lung cancer occurrence.

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“…In China, LC also has a high incidence and mortality, and its morbidity and mortality in men are more than twice that of women [ 6 ]. Most studies have suggested that the occurrence of LC is associated with environmental (smoke, occupational exposure, and air pollution) and genetic factors [ 7 , 8 ]. In particular, genetic factors play an essential role in the occurrence of LC.…”

Section: Introductionmentioning

confidence: 99%

Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study

Dang¹,

Zhao²,

Li³

et al. 2021

PLoS ONE

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Lung cancer (LC) is a malignant tumor that poses the greatest threat to human health and life. Most studies suggested that the occurrence of LC is associated with environmental and genetic factors. We aimed to explore the association between COL6A4P2 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Based on the ‘case-control’ experimental design (510 cases and 495 controls), we conducted an association study between five candidate COL6A4P2 SNPs and the corresponding LC risk. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression to analyze the LC susceptibility under different genetic models. The results showed that COL6A4P2 rs34445363 was significantly associated with LC risk under alleles model (OR = 1.26, 95%CI: 1.01–1.58, p = 0.038). In addition, rs34445363 was also significantly associated with LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01–1.58, p = 0.041). The results of subgroup analysis showed that rs34445363 (OR = 1.42, 95%CI: 1.03–1.95, p = 0.033) and rs61733464 (OR = 0.72, 95%CI: 0.52–0.99, p = 0.048) were both significantly associated with LC risk in the log-additive model among participants who were ≤ 61 years old. We also found that the variation of rs34445363 (GA vs. GG, OR = 1.73, 95%CI: 1.04–2.86, p = 0.034) and rs77941834 (TA vs. TT, OR = 1.88, 95%CI: 1.06–3.34, p = 0.032) were associated with LC risk in the codominant model among female participants. Our study is the first to find that COL6A4P2 gene polymorphism is associated with LC risk in the Chinese Han population. Our study provides a basic reference for individualized LC prevention.

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Prevalence, risk factors, and impact of lung Cancer on outcomes of idiopathic pulmonary fibrosis: a study from the Middle East

Cited by 10 publications

References 29 publications

Value of modified Burns Wean Assessment Program scores in the respiratory intensive care unit: An Egyptian study

Value of modified Burns Wean Assessment Program scores in the respiratory intensive care unit: An Egyptian study

Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study

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