Prevalence of TBE antibodies in serum and CSF of dogs with inflammatory and non-inflammatory CNS disease

Reiner, B.; Grasmück, Sophie; Steffen, Franziska; Djuric, Niek; Schindler, T.; Müller, Werner; Fischer, Andrea

doi:10.1016/s1438-4221(02)80069-8

Cited by 14 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a number of studies in known TBE-endemic areas Germany and Austria, the antibody prevalence rate has been determined to range between 10 and 30%. In one study in Germany, the prevalence rate in healthy dogs was 31%, while the prevalence rate in dogs with neurological symptoms was 53% [ 36 ]. The antibody prevalence rate of 22.1% found in the current study lies well in the range of earlier studies and confirms that the dogs were coming from an endemic area in south-western Germany.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Three Serological Methods for the Epidemiological Investigation of TBE in Dogs

et al. 2021

View full text Add to dashboard Cite

Tick-borne encephalitis (TBE) virus is an emerging pathogen that causes severe infections in humans. Infection risk areas are mostly defined based on the incidence of human cases, a method which does not work well in areas with sporadic TBE cases. Thus, sentinel animals may help to better estimate the existing risk. Serological tests should be thoroughly evaluated for this purpose. Here, we tested three test formats to assess the use of dogs as sentinel animals. A total of 208 dog sera from a known endemic area in Southern Germany were tested in an All-Species-ELISA and indirect immunofluorescence assays (IIFA), according to the manufacturer’s instructions. Sensitivity and specificity for both were determined in comparison to the micro-neutralization test (NT) results. Of all 208 samples, 22.1% tested positive in the micro-NT. A total of 18.3% of the samples showed characteristic fluorescence in the IIFA and were, thus, judged positive. In comparison to the micro-NT, a sensitivity of 78.3% and a specificity of 98.8% was obtained. In the ELISA, 19.2% of samples tested positive, with a sensitivity of 84.8% and a specificity of 99.4%. The ELISA is a highly specific test for TBE-antibody detection in dogs and should be well suited for acute diagnostics. However, due to deficits in sensitivity, it cannot replace the NT, at least for epidemiological studies. With even lower specificity and sensitivity, the same applies to IIFA.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Three Serological Methods for the Epidemiological Investigation of TBE in Dogs

et al. 2021

View full text Add to dashboard Cite

show abstract

“…); 19% of unvaccinated forestry workers in the Bodenseekreis and 15% in the Kreis Konstanz were seropositive for TBEV ( 9 ). The prevalence of TBEV in ticks was 1.2%–2.3% in the Bodenseekreis ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Tickborne Encephalitis in Naturally Exposed Monkey (Macaca sylvanus)

Süß

Gelpí

Klaus

et al. 2007

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Dogs are highly susceptible to tick‐borne encephalomyelitis virus infection, but rarely show clinical signs. Cases of tick‐borne encephalomyelitis in dogs have been reported from several endemic areas in Europe . Tick‐borne encephalomyelitis virus is a neurotropic RNA virus, which causes a nonsuppurative encephalomyelitis in dogs, characterized by widespread neuronophagia and gliosis throughout the gray matter of the central nervous system, but mainly involving the brainstem, cerebellum, and ventral horn of the spinal cord .…”

Section: Introductionmentioning

confidence: 99%

“…Currently, no effective treatment against tick‐borne encephalomyelitis infection is available in dogs. The prognosis has been considered poor, in particular during the first week of the disease . The purpose of this retrospective case series study was to describe the clinical and 3 Tesla (3T) MRI characteristics, as well as the outcome in a group of dogs with confirmed diagnosis of tick‐borne encephalomyelitis.…”

Section: Introductionmentioning

confidence: 99%

Three Tesla Magnetic Resonance Imaging Findings in 12 Cases of Canine Central European Tick‐borne Meningoencephalomyelitis

Beckmann

Steffen

Ohlerth

et al. 2015

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Central European tick-borne encephalomyelitis can be challenging to diagnose in dogs because the virus may not be detected in blood and cerebrospinal fluid (CSF) after the first viremic stage of the disease. The purpose of this retrospective case series study was to describe 3 Tesla magnetic resonance imaging (3T MRI) findings in a sample of dogs with a confirmed diagnosis of tick-borne encephalomyelitis. Dogs were included if they had neurological signs consistent with tick-borne encephalomyelitis, history of a stay in endemic areas for tick-borne encephalomyelitis virus, 3T MRI of the brain and/or spinal cord, cerebrospinal fluid changes compatible with viral infection and positive antibody titers in cerebrospinal fluid or pathologic confirmation of tick-borne encephalomyelitis. Twelve dogs met inclusion criteria. Ten out of 12 patients had 3T MRI lesions at the time of presentation. One patient had persistent lesions in follow-up MRI. The 3T MRI findings included bilateral and symmetrical gray matter distributed lesions involving the thalamus, hippocampus, brain stem, basal nuclei, and ventral horn on the spinal cord. All lesions were hyperintense in T2-weighted sequences compared to white matter, iso- to hypointense in T1-weighted, nonenhancing, and had minimal or no mass effect or perilesional edema. Six patients survived while the remaining six dogs were euthanized. Necropsy revealed neuronophagia and gliosis of the gray matter of the affected regions seen in 3T MRI, in addition to the cerebellum. Findings from the current study indicated that tick-borne encephalomyelitis should be included in the differential diagnosis list for dogs with the above described 3T MRI characteristics.

show abstract

Prevalence of TBE antibodies in serum and CSF of dogs with inflammatory and non-inflammatory CNS disease

Cited by 14 publications

References 0 publications

Comparison of Three Serological Methods for the Epidemiological Investigation of TBE in Dogs

Comparison of Three Serological Methods for the Epidemiological Investigation of TBE in Dogs

Tickborne Encephalitis in Naturally Exposed Monkey (Macaca sylvanus)

Three Tesla Magnetic Resonance Imaging Findings in 12 Cases of Canine Central European Tick‐borne Meningoencephalomyelitis

Contact Info

Product

Resources

About