2017
DOI: 10.1590/s0004-2803.201700000-06
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Abstract: -Background -Small intestine bacterial overgrowth is a heterogeneous syndrome characterized by an increase in the number and/or the presence of atypical microbiota in the small intestine. The symptoms of small intestine bacterial overgrowth are unspecific, encompassing abdominal pain/distension, diarrhea and flatulence. Due to the increased cost and complexity for carrying out the jejunal aspirate, the gold standard for diagnosis of the syndrome, routinely the hydrogen (H 2 ) breath test has been used, utilizi… Show more

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Cited by 7 publications
(3 citation statements)
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“…This finding, if replicated in another larger cohort, is significant as the rationale for inclusion of methane analysis alongside hydrogen analysis when testing for SIBO or carbohydrate malabsorption is that hydrogen is consumed by archaea, which utilize 4 mol of hydrogen to produce 1 mol of methane. Therefore, when methane is produced, there is likely to be a reduction in hydrogen produced, and including methane in the test will improve its sensitivity …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This finding, if replicated in another larger cohort, is significant as the rationale for inclusion of methane analysis alongside hydrogen analysis when testing for SIBO or carbohydrate malabsorption is that hydrogen is consumed by archaea, which utilize 4 mol of hydrogen to produce 1 mol of methane. Therefore, when methane is produced, there is likely to be a reduction in hydrogen produced, and including methane in the test will improve its sensitivity …”
Section: Discussionmentioning
confidence: 99%
“…Therefore, when methane is produced, there is likely to be a reduction in hydrogen produced, and including methane in the test will improve its sensitivity. 15,21,22 While those advocating for the inclusion of methane analysis in the breath test state its value in increasing sensitivity, less consideration has been given to its effect on test specificity, which will likely decrease. In this audit, the variability in methane readings if lactulose was used as a substrate makes it questionable whether a rise in breath methane levels is truly representative of the increased fermentation of the substrate provided or if the rise is independent of ingestion of lactulose.…”
Section: Discussionmentioning
confidence: 99%
“…4,5,7 In an examination with hydrogen breath tests on patients with gastrointestinal symptoms, there is 56% of patients positively diagnosed with SIBO while in a study that was conducted in 2003, there was a prevalence of 66% in the patients with celiac disease. 8,9 In another study with different celiac disease patients, prevalence numbers were resulted differently according to applied examination, including jejunal aspiration and breath test, which found as many as 11% and 23%, respectively. 10 Recently, a meta-analysis study showed that the prevalence of SIBO in the IBS population was 38% dan odds of SIBO were increased 11…”
Section: Epidemiologymentioning
confidence: 99%