2019
DOI: 10.1002/jgh3.12240
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Abstract: Background and Aim Breath testing (BT) is used to identify carbohydrate malabsorption and small intestine bacterial overgrowth. Measuring methane alongside hydrogen is advocated to reduce false‐negative studies, but the variability of methane production is unknown. The aim of this study is to examine the effect of high methane production on hydrogen excretion after ingesting lactulose, fructose, or lactose. Methods A retrospective audit was performed of patients with gastrointestinal symptoms who underwent BT.… Show more

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Cited by 12 publications
(4 citation statements)
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“…Probably, this difference could be due to the different type of population analyzed. Prevalence of elevated CH 4 , baseline levels in our work was similar to that observed in a study of Harvie et al 17 who estimated a prevalence of 26% of high CH 4 producers. However, they established 5 ppm as baseline cut-off.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Probably, this difference could be due to the different type of population analyzed. Prevalence of elevated CH 4 , baseline levels in our work was similar to that observed in a study of Harvie et al 17 who estimated a prevalence of 26% of high CH 4 producers. However, they established 5 ppm as baseline cut-off.…”
Section: Discussionsupporting
confidence: 91%
“…To our knowledge, this is one of the first studies with larger sample size focused in baseline breath measurements. First of all, we observed the presence of methanogenic microbiota determined by the presence of CH 4 in breath, in a high percentage of the patients, higher than the prevalence previously indicated 17 , 18 . Levitt et al 18 found that only 36% of patients presented CH 4 levels higher than 1 ppm.…”
Section: Discussionmentioning
confidence: 50%
“…(c) Hydrogen production may be reduced because of low colonic pH (Perman et al, 1981). There is a proportion of the population who are occasional nonproducers of hydrogen, which could be related to normal shifts of bacterial flora (La Brooy et al, 1983) measuring methane alongside hydrogen is advocated but the variability of methane production is unknown (Harvie et al, 2019). (d) There is poor reproducibility of lactulose breath testing (Yao & Tuck, 2017).…”
Section: Gastrointestinal Transit Lactulose Challenge Test For Octt Lowmentioning
confidence: 99%
“…The increase in exhaled H 2 results from the release of gases by heterofermentative bacteria that digest lactose [53]. However, the correlation between lactose malabsorption (or the load of undigested lactose) and LI (presence of symptoms) is not always clear: The HBT is thought to produce 5%-15% false negatives, mainly due to non-hydrogen production and methane production [54][55][56].…”
Section: Discussionmentioning
confidence: 99%