Prevalence of small cerebral bleeds in patients with a neurodegenerative dementia: A neuropathological study

Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia

“…Earlier neuropathologic studies showed a relatively high prevalence of AD pathology and lobar microhemorrhages, including cerebral amyloid angiopathy pathology, in individuals with DLB. 27,44 These findings support ours. Because our DLB group was of the most advanced mean age, the age factor might have played a role in the induction of cerebral amyloid angiopathy pathology in this group.…”

“…Moreover, a neuropathologic study showed a relatively high prevalence of ␤-amyloid pathology and cortical microhemorrhages in the brains of patients with DLB 27,44 and a low prevalence of ␤-amyloid pathology in patients with FTLD. 27,45 We suggest that SHF on SWI may be associated with ␤-amyloid pathology in these diseases.…”

“…26 Although histologic studies found a relatively high prevalence of microhemorrhages in the brains of patients with DLB at postmortem examination, 27 no MR imaging studies examining SHF in patients with DLB have been reported. Although there are a few studies of SHF detected on SWI of control subjects and patients with the limited type of dementia, 21,28 no cohort studies have evaluated the prevalence and topography of SHF on 3T SWI in various types of dementia.…”

The topography of cortical microbleeds in frontotemporal lobar degeneration: a post-mortem 7.0-tesla magnetic resonance study

“…In our recent neuropathological assessment of small cerebrovascular lesions, only a prevalence of white matter changes was observed in the FTLD brains, compared to age-matched controls [10]. These findings are in contrast to the high incidence of macroand micro-infarcts, and hematomas and small cerebral bleeds observed in brains of patients with Alzheimer's disease (AD), in particular in those with associated cerebral amyloid angiopathy (CAA) [6,7].…”

Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease

“…At the same time, a large proportion of patients with AD do also have cerebral microbleedings, which are associated with CAA (De Reuck et al, 2011) and pronounced microvascular changes with decreased density and structural abnormalities causing regional metabolic and blood-brain barrier dysfunctions (Jellinger, 2002). Colocalized with sites of greatest amounts of neurodegeneration, the basement membrane of capillaries in the cerebral cortex of AD patients is prominently thickened, mostly due to increased collagen deposition (Mancardi et al, 1980) and deposition of amorph Aβ fibrils (reviewed in Farkas and Luiten, 2001).…”