Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia

Uetani, Hiroyuki; Hirai, Toshinori; Hashimoto, Mamoru; Ikeda, Manabu; Kitajima, Mika; Sakamoto, Fumi; Utsunomiya, Daisuke; Oda, Shoichiro; Sugiyama, Seigo; Matsubara, Junichi; Yamashita, Yoshimi

doi:10.3174/ajnr.a3332

Cited by 42 publications

(33 citation statements)

References 50 publications

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“…[8][9][10][11] Their impact on cognition is still a matter of debate. Several studies supported a deleterious effect of CMBs, including increased prevalence in vascular dementia but also in Alzheimer disease, 3,[12][13][14] associations with poorer cognitive function in cross-sectional studies of patients with dementia, 15 lower A␤42 levels in the CSF in Alzheimer disease and vascular dementia, 16 and decreased frontal-executive performances at 5-year follow-up in patients with stroke. 17 However, negative data were also reported with no or marginal impact of CMBs in early Alzheimer disease (for a review see van der Flier 18 and Heringa et al 19 ) and in subjects with subcortical vascular cognitive impairment 20 and symptomatic small-vessel disease.…”

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confidence: 99%

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Barnaure¹,

Montandon²,

Rodriguez³

et al. 2016

AJNR Am J Neuroradiol

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Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Barnaure¹,

Montandon²,

Rodriguez³

et al. 2016

AJNR Am J Neuroradiol

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“…SWI has been shown to increase the number of CMBs detected, 3,14,15 and studies using the SWI sequence rather than T2* show a higher number and, in some cases, prevalence of CMBs. 14,16,17 The conventional SWI sequence has a thinner section thickness than the T2* sequence. A thin section thickness has been shown to increase CMB detection 15 ; thus, this might contribute to the increased CMB detection seen with SWI.…”

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confidence: 99%

SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study

Shams¹,

Martola²,

Cavallin³

et al. 2015

AJNR Am J Neuroradiol

100

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“…In this study, the prevalence and number of CMB was higher than earlier reports using 3T SWI in memory clinic setting (Goos et al., 2011; Shams et al., 2015; Uetani et al., 2013). The differences in age and disease prevalence between earlier studies and ours may have also influenced these results.…”

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confidence: 99%

Background and distribution of lobar microbleeds in cognitive dysfunction

et al. 2017

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ObjectivesCerebral microbleeds (CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D‐CMBs) result from hypertensive vasculopathy (HV), whereas strictly lobar CMBs (SL‐CMBs) result from cerebral amyloid angiopathy (CAA) which frequently coexists with Alzheimer's disease (AD). Mixed CMBs (M‐CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL‐CMBs and M‐CMBs in terms of clinical features and regional distribution.MaterialsWe examined 176 sequential patients in our memory clinic for clinical features and CMB location using susceptibility‐weighted images obtained on a 3T‐MRI. The number of lobar CMBs in SL‐CMBs and M‐CMBs was counted in each cerebral lobe and their regional density was adjusted according to the volume of each lobe.ResultsOf the total 176 patients, 111 patients (63.1%) had CMBs. Within the patients who had CMBs, M‐CMBs were found in 54 patients (48.6%), followed by SL‐CMBs in 35 (31.5%) and D‐CMBs in 19 (17.1%). The SL‐CMB group showed a significantly higher prevalence of family history of dementia, whereas the M‐CMB group showed an increasing trend toward hypertension and smoking. The prevalence of AD was significantly higher in the SL‐CMBs group, whereas the prevalence of AD with cerebrovascular disease was higher in the M‐CMBs group. The regional density of lobar CMBs was significantly higher in the occipital lobe in the M‐CMB group, whereas the SL‐CMB group showed higher regional density between regions an increasing tendency in the parietal and occipital lobe.ConclusionThe between‐group differences in clinical features and regional distribution indicate there to be an etiological relationship of SL‐CMBs to AD and CAA, and M‐CMBs to both HV and CAA.

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Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia

Cited by 42 publications

References 50 publications

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study

Background and distribution of lobar microbleeds in cognitive dysfunction

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