Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009–2015

Yu, Jianxing; Lai, Shengjie; Geng, Qibin; Ye, Chuchu; Zhang, Zi-Ke; Zheng, Yaming; Wang, Liping; Duan, Zhaojun; Zhang, Jing; Wu, Shuyu; Parashar, Umesh D.; Yang, Weizhong; Liao, Qiaohong; Li, Zhongjie

doi:10.1016/j.jinf.2018.07.004

Cited by 45 publications

(48 citation statements)

References 31 publications

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“…In China, both temporal and spatial diversity of rotavirus have been observed. From 2009‐2015, the most dramatic change observed was that the previously predominant strains, G3P[8] and G1P[8], were rapidly replaced by genotype G9P[8] across all regions in the country in the most recent years, increasing from 3.4% in 2009 to 61.3% of all isolates in 2015 . In addition, G3P[8] was the most common strain in Lulong, Changchun, whereas G1P[8] was the most common strain in Lanzhou during 2006‐2007 .…”

Section: Introductionmentioning

confidence: 99%

“…From 2009-2015, the most dramatic change observed was that the previously predominant strains, G3P [8] and G1P [8], were rapidly replaced by genotype G9P [8] across all regions in the country in the most recent years, increasing from 3.4% in 2009 to 61.3% of all isolates in 2015. 16 In addition, G3P [8] was the most common strain in Lulong, Changchun, whereas G1P [8] was the most common strain in Lanzhou during 2006-2007. 17 The temporal and spatial diversity in the prevalence rotaviruses showed the necessity of continued and multiregional surveillance of rotaviruses.…”

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confidence: 99%

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Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011‐2015

Zeng

Zhao

et al. 2019

Journal of Medical Virology

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Human group A rotavirus (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years old worldwide. The aim of this study was to investigate the genotype distribution of RVA in the Midwest of China. Sentinel‐based surveillance of acute diarrhea was conducted at Children's Hospital of Chongqing Medical University from 2011 to 2015. RVA was tested by using enzyme‐linked immunosorbent assays. The partial VP4 genes and VP7 genes of rotavirus were amplified and sequenced, and genotyping and phylogenetic analyses were performed. Among the 2236 stool specimens collected from children with acute gastroenteritis, 681 (30.46%) were positive for RVA. The majority of children (89.28%) who tested positive for RVA were children aged ≤2 years. The seasonal peak of RVA was in the winter. As for genotype, four strain combinations, G9P[8], G3P[8], G1P[8], and G2P[4] contributed to 75.62% (515/681) of the RVA‐associated diarrhea cases. After a marked increase in G9P[8] (30.77%) in 2013, G9P[8] became the predominant genotype in 2014 and 2015, whilst the prevalence of G1P[8] was decreased to 2.72% in 2015. Unusual G‐P combinations (eg, G1P[4], G9P[4], G4P[6], G3P[4], G2P[8]) were also detected sporadically over the study period. Phylogenetic tree analysis results showed that the VP7 sequences of G9 strains were clustered into two main lineages, and 77.34% of them were clustered into lineage VI, with the highest nucleotide similarity to the strain JS12‐17(China). VP4 gene sequences of P[8] strains were almost P[8]‐lineage 3. Substantial temporal variation in the circulation of various genotypes of rotavirus in Chongqing was observed during 2011‐2015, and highlights the need for continuous surveillance of RVA infection for better understanding and control of RVA infection.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011‐2015

Zeng

Zhao

et al. 2019

Journal of Medical Virology

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“…Human sapovirus (SaV) belongs to the common viral agent of acute diarrhea globally, especially after the successful introduction of rotavirus vaccines . In China, a domestic Jennerian vaccine (the Lanzhou lamb rotavirus vaccine) has been licensed since 2000, and at the end of 2014, over 60 million doses had been distributed to children . SaV can cause disease in people of all age groups, but most infections occurred in children .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 In China, a domestic Jennerian vaccine (the Lanzhou lamb rotavirus vaccine) has been licensed since 2000, and at the end of 2014, over 60 million doses had been distributed to children. 3 SaV can cause disease in people of all age groups, but most infections occurred in children. 4 The clinical symptoms of SaV gastroenteritis are similar as those infected by human noroviruses, mainly including diarrhea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genetic diversity of human sapovirus associated with sporadic acute gastroenteritis in South China from 2013 to 2017

Xue¹,

Cai²,

Zhang³

et al. 2019

Journal of Medical Virology

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Human sapovirus (SaV) is an important viral agent for acute diarrhea worldwide, but timely prevalence data of human SaV in South China are still lacking. In this study, a 4‐year surveillance was conducted to characterize the prevalence and genetic characteristics of the circulating SaV associated with sporadic diarrhea in South China. From November 2013 to October 2017, 569 fecal samples from patients with acute diarrhea were collected. SaV was detected in 11 samples with a positive rate of 1.93%. Three human genogroups of GI, GII, and GIV were identified, including five GI.1 strains, three GI.2 strains, one GI.3 strain, one GII.8 strain, and one GIV strain. Furthermore, multiple alignments of complete capsid protein VP1 genes of five local GI.1 strains and other available GI.1 strains in GenBank were performed. Average pairwise identities were calculated at 95.33% and 99.36% at nucleotide and amino acid levels, and only six variable amino acid sites were found during its 36‐years’ evolution process. GI.1 strains could be further phylogenetically divided into four clusters with an approximate temporal evolution pattern, and local strains belonged to Cluster‐d with other four strains from China and Japan. In summary, SaV was identified as an etiological agent responsible for sporadic gastroenteritis in Guangzhou with a low prevalence rate as in other Chinese cities, but its high genetic diversity suggested the necessity of continuous SaV surveillance in the future.

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“…In mainland China, the first G9 strain was detected in 1994, and G9 strains were uncommon before 2007 (Li et al, 2009). Recently, however, G9 RVA has emerged as the predominant genotype in China (Dian et al, 2017;Yu et al, 2018). The RVA G9P[23] genotype has been detected in Thailand, the United States, Japan, South Korea, Italy, Belgium, Brazil, mainland China and Taiwan .…”

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Genome analysis of a G9P[23] group A rotavirus isolated from a dog with diarrhea in China

Yan

Tang

Kan

et al. 2019

Infection, Genetics and Evolution

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Genotype G9 is an emerging genotype among species A rotavirus (RVA) circulating in humans and pigs worldwide. In this study, an RVA strain designated RVA/Dog-tc/CHN/SCCD-A/2017/G9P[23] was isolated in cell culture from a pet dog stool sample with acute diarrhea, and its whole genome was sequenced. The genotype constellation of SCCD-A was G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. All genome segments except the VP1 gene were closely related to the genes from porcine RVA strains or porcine-like human RVA strains. On the other hand, the VP1 gene clustered in a distinct lineage only with that of a G5P[6] porcine-like human RVA, preventing the identification of the exact host species origin, but very unlikely to be originated from human RVA. In addition, phylogenetic analysis showed that the G9 VP7 gene of SCCD-A clustered into a novel sublineage within the lineage III of G9. This first isolation of a G9P[23] RVA from a pet dog may justify the exploration of the role dogs play in the interaction of RVA circulating in pigs and humans.

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Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009–2015

Cited by 45 publications

References 31 publications

Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011‐2015

Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011‐2015

Prevalence and genetic diversity of human sapovirus associated with sporadic acute gastroenteritis in South China from 2013 to 2017

Genome analysis of a G9P[23] group A rotavirus isolated from a dog with diarrhea in China

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