Prevalence of primary Sjögren's syndrome in patients with multiple sclerosis

Abstract

Sixty-four consecutive patients with clinically or laboratory-supported definite multiple sclerosis (MS) were evaluated prospectively for evidence of primary Sjögren's syndrome (SS). This diagnosis was established when a patient had objective keratoconjunctivitis sicca, xerostomia, or both together with positive labial salivary gland biopsy. We found 2 patients (3.1%) with clinical evidence of primary SS. Whether this association is fortuitous or whether there is pathogenetic linkage between MS and primary SS remains to be established.

Neurological Manifestations of Primary Sjoegren's Syndrome in Japanese Patients.

“…The reasons why dorsal root ganglia and trigeminal ganglia were most frequently involved still remain unknown,but neurons in these nerves have short axons so that they may easily be affected by ganglioneuronopathy. Previous reports showedthat typical central nervous system involvement in SjS exhibits a MS-like appearance (7)(8)(9) In this study, we showedthat 87%of SjS-related nervous system manifestations occurred in the peripheral nervous system. Central nervous system involvement was observed less in our study than in that previously reported (1).…”

Multiple sclerosis and exposure to solvents, ionizing radiation and animals.

“…Recent studies support the ideas that certain human leucocytlocu s A (HLA) haplotypes imply increased susceptibility to multiple sclerosis (1)(2)(3)(4)(5) and that infection s (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), for example , retro virus (16)(17)(18) , may play a role in the patho genesis. There are several observations regarding the associated occurrence of multipl e sclerosis with other autoimmune disorders ( 19), like myas then ia gravis (20), thyroid disease (2 1), and Sjogren ' s syndrome (22), but also with such clearly HLA-Iinked conditions as ankylosing spondylitis (23) and narcolepsy (24,25 ).…”

Gougerot Sjögren Syndrome Mimicking Multiple Sclerosis

“…This last hypothesis was supported by some studies [3][4][5]. The prevalence of GSS in MS patients varies in the published literature (0-16.6%) [3].…”

“…In the study of Miró [4] sixty-four patients with clinically or laboratory-supported definite MS were evaluated for evidence of GSS, 2 patients (3.1%) were found with clinical evidence of GSS. SandbergWollheim [5] concludes that MS and GSS may coexist in the same individual, but GSS is not more common among MS patients than expected in the general population.…”