Prevalence of preclinical renal dysfunction in obese Egyptian patients with primary knee osteoarthritis, preliminary data

Zayed, Hania S.; Younis, Gehan; Bader, Reem; Amin, Alaa S.

doi:10.1016/j.ejr.2013.06.002

Cited by 4 publications

(4 citation statements)

References 39 publications

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“… 17 MetS was reported in nine articles, 4 20 24 28 30 36 40 43 50 the prevalence of MetS ranged from 5% 24 to 97.5%. 40 The prevalence of obesity ranged from 7.8% 51 to 100% 15 40 and BMI from 22.3±2.7 30 to 37.3±5.9 g/cm 2 . 40 Seven articles described the use of statin treatment (t able 3).…”

Section: Resultsmentioning

confidence: 95%

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Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis

et al. 2017

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ObjectivesWe aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated.MethodsWe performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA.ResultsFrom 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001).ConclusionThe risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype.

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Section: Resultsmentioning

confidence: 95%

“… 40 The prevalence of obesity ranged from 7.8% 51 to 100% 15 40 and BMI from 22.3±2.7 30 to 37.3±5.9 g/cm 2 . 40 Seven articles described the use of statin treatment (t able 3).…”

Section: Resultsmentioning

confidence: 95%

Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis

et al. 2017

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“…69 There is evidence that glomerular filtration rate correlates inversely with the severity of knee osteoarthritis. 70 For this reason, many studies have been and are being done to evaluate the effect of renal tonics in the treatment of osteoarthritis. 71 Many of the plants that Avicenna introduced to relieve pain of arthritis have diuretic properties (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Scientific Evaluation of Pharmacological Treatment of Osteoarthritis in the Canon of Medicine

Choopani

Ghourchian

Hajimehdipoor

et al. 2015

J Evid Based Complementary Altern Med

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Osteoarthritis is the most common articular disease worldwide. Nonetheless, common osteoarthritis treatments are either not effective or associated with side effects. Now the materials derived from plants have found a relevant place in drug discovery. Until the mid-18th century, osteoarthritis in all medical schools worldwide had been managed as general arthritis. Avicenna, the famous scholar of Iranian traditional medicine has provided a long list of herbs that have been used traditionally to treat arthritis. To gain this worthy list, we searched his most famous medical masterpiece: Canon of Medicine Some of these materials are investigated and employed by modern medicine. However, it is difficult to ignore that still more of these naturally occurring materials could be of use in modern medicine not only to prevent osteoarthritis progression but also osteoarthritis management as natural anti-inflammatory drugs.

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“…In a previous study on Egyptian patients with KOA it was found that synovial vascular endothelial growth factor (VEGF) remarkably correlated with clinical manifestations, functional impact, as well as radiological changes [5]. In other studies, osteopontin served as a biochemical marker of disease severity in KOA [6] and obesity increased the risk of renal dysfunction [7] in Egyptian patients with KOA. It has furthermore been reported that the measurements of hyaluronic acid and serum cartilage oligomeric matrix protein may be of diagnostic and prognostic value in differentiating patients with early KOA.…”

Section: Introductionmentioning

confidence: 96%

Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

Hussein

Sharara

2016

The Egyptian Rheumatologist

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Aim of the work: The aim of the present work was to correlate between serum level of leptin, matrix metalloproteinase-13 (MMP13), interleukin-1b (IL1b), tumour necrosis factor (TNFa), nitric oxide (NO) and functional impact in obese patients with knee osteoarthritis (KOA).Patients and methods: The study included 84 obese patients suffering from primary KOA. The knees were examined; pain assessed by visual analogue scale (VAS) and Lequesne's index for functional impact calculated. Serum leptin, MMP13, IL1b, TNF-a and NO were assessed.Results: The mean age of the patients was 54.64 ± 7.7 years. They were 72 females and 12 males (F:M = 6:1) with a mean BMI of 35.29 ± 4.8. Sixty patients had knee effusion which was bilateral in 54 (64.3%), unilateral in 6 (7.2%) while 24 (28.6%) did not have any effusion. Knee deformities were present in 60 (71.4%) patients. Female patients were only significantly higher than males regarding Lequesne's index (15.08 ± 4.4 vs 11 ± 3.4, p = 0.003). Patients with knee deformity had significantly higher VAS (9.12 ± 1.3 vs 6.96 ± 0.46, p = 0.001), IL1b (621.1 ± 98.8 vs 503.9 ± 74.6 pg/ml, p = 0.001), TNF-a (115.4 ± 29.1 vs 87.4 ± 4.4 pg/ml, p = 0.001), NO (67.32 ± 5.7 vs 59.2 ± 2.2 lmol/L, p = 0.001), MMP13 (33.98 ± 2.24 vs 30.1 ± 1.7 ng/ml, p = 0.012) and leptin (13.2 ± 1.6 vs 10.4 ± 0.6, p = 0.004) than those without. The VAS, Lequesne index, IL1b, TNF-a NO, MMP13 and leptin were significantly higher in patients with bilateral knee effusion (p < 0.0001 for all) compared to those with unilateral effusion or without. Leptin significantly correlated with BMI, VAS, Lequesne's index, IL1b, TNFa, NO and MMP13 (p < 0.0001 for all).Conclusion: Leptin plays a key role in obese patients with knee OA. It significantly correlates with knee pain, functional impairment, inflammatory cytokines and cartilage degradation.

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Prevalence of preclinical renal dysfunction in obese Egyptian patients with primary knee osteoarthritis, preliminary data

Cited by 4 publications

References 39 publications

Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis

Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis

Scientific Evaluation of Pharmacological Treatment of Osteoarthritis in the Canon of Medicine

Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

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