Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

Hussein, Naglaa; Sharara, Gihan M.

doi:10.1016/j.ejr.2015.05.003

Cited by 13 publications

(3 citation statements)

References 32 publications

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“…Obesity is a significant risk factor for knee osteoarthritis (OA) and also increases risk of OA in nonweight-bearing joints, leading Hussein and Sharara to suggest that mechanical factors alone may not explain the impact of obesity on knee OA. 46 Their study of 84 patients with obesity and knee OA implicates the hormone leptin, which was not only significantly correlated with BMI but was also shown to be significantly correlated with levels of specific cytokines (IL1b and TNFa) and certain metalloproteinases (MMP13), which enhance cartilage degradation.…”

Section: Obesity Comorbiditiesmentioning

confidence: 99%

Obesity in Women: Insights for the Clinician

Tauqeer

Gomez

Stanford

2018

Journal of Women's Health

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As a leading cause of morbidity and mortality in the United States and worldwide, obesity is a disease that is frequently encountered in clinical practice today and requires a range of medical interventions. While obesity affects both men and women across all ages, multiple issues are particularly germane to women's health, particularly as obesity is more prevalent among women than men in the United States and obesity among women of reproductive health relates to the growing issue of childhood obesity. Discussed herein are the epidemiology and pathophysiology of obesity along with the impact of perinatal obesity on fetal programming. Guidance on screening and management of obesity through lifestyle intervention, pharmacologic therapy, and bariatric surgery, as well as avoidance of weight-promoting medications wherever possible, is elaborated. Particular attention is paid to the contribution of these modalities to weight loss as well as their impact on obesity-related comorbidities that affect a woman's overall health, such as type 2 diabetes and hypertension, and her reproductive and gynecologic health. With modest weight loss, women with obesity can achieve notable improvements in chronic medical conditions, fertility, pregnancy outcomes, and symptoms of pelvic floor disorders. Moreover, as children born to women after bariatric surgery-induced weight loss show improved metabolic outcomes, this demonstrates a role for maternal weight loss in reducing risk of development of metabolic disturbances in children. In light of the immense cost burden and mortality from obesity, it is important to emphasize the role of lifestyle intervention, pharmacologic management, and bariatric surgery for weight loss in clinical practice to mitigate the impact of obesity on women's health.

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Section: Obesity Comorbiditiesmentioning

confidence: 99%

Obesity in Women: Insights for the Clinician

Tauqeer

Gomez

Stanford

2018

Journal of Women's Health

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“…The characteristic of the age in this study showed the average age of the patient who had been diagnosed with OA genu was 63,6 years old with a range of 53-82 years old. The relationship between age with gender to the occurrence of OA was closely related, according to the statement of Felson, Roman-blas et al, Hussein, and Sharara, were the most diagnosed of OA was a female with age more than 50 years old (after menopause) because it was related to the role of hormones that affected cartilage metabolism [1,10,11]. The aging of the cartilage causes damage function and structure of chondrocytes thereby disrupting homeostasis and reducing the quality of the cartilage matrix [1,10,[12][13][14].…”

Section: A Characteristic Of Reasearch Subjectsmentioning

confidence: 99%

A Correlation of OA Genu Severity and Radiological Description

Buana¹,

Priatna²,

Kusmala³

2021

Advances in Health Sciences Research

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Osteoarthritis (OA) was a degenerative, chronically progressive disease of the joints. The most common medical condition among older adults was osteoarthritis. The research aimed to find the correlation between the severity of OA and the radiological description. The method of this study was an analytical method using a cross-sectional design involving 46 subjects consistent with the inclusion criteria for orthopedic surgery and radiology at Dustira Hospital. The sampling methodology was consecutive sampling. Firstly, the participants were interviewed using a questionnaire based on the Lequesne index. Secondly, an expertise of the X-ray genu based on the criteria of Kellegren and Lawrence. The result of this study was a highly significant correlation = 0.750 (p<0.001) according to the Spearman classification correlation. Clinical symptoms may be concluded to be correlated with the radiographic description.

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“…Osteoarthritis (OA) is expected to become more common with increase age and overweight populations. It is characterized by degradation of articular cartilage, osteophytes formation, sclerosis of subchondral bone, joint capsule alterations, destruction of extracellular matrix and synovitis [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Abdel-Magied¹,

AbuOmar²,

Higazi³

et al. 2019

Int. J. Clin. Rheumatol

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Aim of the work: Detection of serum and synovial fluid level of Vascular Endothelial Growth Factor (VEGF) in patients with knee osteoarthritis (OA) and to determine its relation to radiological severity and function status. Patients and methods: Thirty OA patients and thirty controls were included. Function status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Knee pain evaluated using the Visual Analogue Scale (VAS). Serum and synovial fluid level of VEGF were measured. Kellgren-Lawrence grading scale (KL) used to assess radiological severity. Results: The mean of patients' age was 50.33 ± 5.3 years (20 females and 10 males) with disease duration of 7.03 ± 2.12 years. Mean synovial fluid VEGF of OA patients was 964.1 ± 396.72, mean serum VEGF of OA patients was 219.1 ± 96.95. No difference between serum VEGF of patients and control groups (p=0.787). Significant positive correlation between serum and synovial VEGF in OA patients (r=0.58, p=0.001). Significant positive correlation between the synovial fluid VEGF and patients' age, disease duration, inactivity stiffness, ESR, VAS, WOMAC and KL grade scale (p‹0.0001,p=0.029,p‹0.0001,p‹0.0001,p=0.00 3,p‹0.0001,p‹0.0001). Significant positive correlation between serum VEGF and patients' age, inactivity stiffness, WOMAC, ESR and KL grade scale (p‹0.0001, p=0.005, p=0.001, p=0.001,p=0.010). Synovial fluid VEGF was the significant predictors for determining the function status (p‹0.0001); while for determining severity; synovial fluid VEGF, patients' age and VAS were significant predictors (p‹0.0001,p=0.001 and p=0.029 respectively). Conclusion: Serum and synovial fluid VEGF correlated with the clinical features, functional status and radiological features of Knee OA. Synovial VEGF can predict both functional impact and radiological severity in patients with knee OA.

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Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

Cited by 13 publications

References 32 publications

Obesity in Women: Insights for the Clinician

Obesity in Women: Insights for the Clinician

A Correlation of OA Genu Severity and Radiological Description

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

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