Prevalence of potential drug–drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia

Bhagavathula, Akshaya Srikanth; Berhanie, Alemayehu; Tigistu, Habtamu; Abraham, Yishak; Getachew, Yosheph; Khan, Tahir Mehmood; Unakal, Chandrashekhar

doi:10.12980/apjtb.4.2014c1172

Cited by 36 publications

(57 citation statements)

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“…Drug interactions (DIs) are one of the major therapeutic challenges to the treatment of inpatients [1–6]. A potential DI can alter the action of drug,[7] and certain situations like treating special population and comorbid medical complications increase the likelihood of DI or unwanted effects [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…The severity and frequency of the DIs are more prevalent when the patients are receiving multiple drugs [10,11]. Around 11.0% of patients may be found vulnerable for at least one drug–drug interaction (DDI), and the chances of DDI increase nearly 40.0% among patients taking five drugs and >80% in patients taking seven or more medications [2]…”

Section: Introductionmentioning

confidence: 99%

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An exploratory study investigating the potential drug-drug interactions in internal medicine department, Alahsa, Saudi Arabia

Albadr

Bohassan

Ming

et al. 2014

Journal of Pharmaceutical Health Services Research

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Objective The aim of this study was to identify the drug-related problems and drug-drug interactions (DDIs) among the inpatients admitted to an internal medicine ward. Method A prospective, exploratory study was planned and all the prescriptions of inpatients admitted to the internal medicine department from 10 to 24 April 2011 were assessed at a public hospital in Alahsa, Saudi Arabia. Descriptive analysis was performed for sociodemographic aspects of the patients. Prescriptions of the studied population were compiled both for potential drug interactions and number of cases in each class of 'nature of interaction'. All the analysis was performed using SPSS v.18. Key findings Total number of records reviewed during this period was 57. Among these 57 cases, 104 interactions were found. On an average 2 to 11 drugs were prescribed per prescription. In our study, we found that out of the total 104 DDIs, 9 (8.5%) DDIs were serious in nature while the major proportion (69.0%) of the interactions was also significant. It was noticed that the significant DDIs were found associated with the number of drugs (χ 2 = 10.992, degree of freedom (df) = 9, P = 0.002*) and age (χ 2 = 5.494, df = 1, P = 0.019*) of the patients. Conclusion Findings of the current study revealed a high occurrence of DDIs. Number of drugs, age and number of comorbid medical conditions are some of the factor demonstrating a possible association with the DDIs. Patients with cardiovascular disorders were found more prone to one or more DDIs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An exploratory study investigating the potential drug-drug interactions in internal medicine department, Alahsa, Saudi Arabia

Albadr

Bohassan

Ming

et al. 2014

Journal of Pharmaceutical Health Services Research

Self Cite

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“…Thus, among all patients included in this study (N=78), the prevalence of at least one potential drug-drug interaction, regardless of its severity, was 78% (4). Furthermore, in Kenya, about 33.5% of the patients receiving antiretroviral medications were reported to be exposed to clinically significant drug interactions with their antiretroviral medications (16).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

et al. 2014

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Aim:Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo.Methods:A cross-sectional study was conducted including a representative sample of 1921 patients aged ≥18 years (mean age: 57.8±11.2 years; 50.3% women; overall response: 96%) from the regional hospital of Gjilan, Kosovo, during 2011-2013. Potential drug-drug-interactions were assessed and clinical data as well as demographic and socioeconomic information were collected. Binary logistic regression was used to assess the correlates of drug-drug interactions.Results:Upon multivariable adjustment for all the demographic and socioeconomic factors as well as the clinical characteristics, drug-drug interactions were positively and significantly related to older age (OR=2.1, 95%CI=1.3-2.8), a lower educational attainment (OR=1.4, 95%CI=1.1-1.9), a longer hospitalization period (OR=2.7, 95%CI=2.1-3.6), presence of three groups of diseases [infectious diseases (OR=1.7, 95%CI=1.3-2.4), cardiovascular diseases (OR=1.8, 95%CI=1.4-2.6), respiratory diseases (OR=1.6, 95%CI=1.2-2.5)], presence of comorbid conditions (OR=3.2, 95%CI=2.3-4.4) and an intake of at least four drugs (OR=5.9, 95%CI=4.6-7.1).Conclusions:Our study provides important evidence on the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the hospitalized patients in the regional hospital of Gjilan, Kosovo. Findings from our study should raise the awareness of decision-makers and policy makers about the prevalence and determinants of drug-drug interactions in the adult population of post-war Kosovo.

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“…Similar results have been revealed in Bangladesh where due to very poor drug information facilities in health care settings, accompanying the scarcity of lot of clinical data and drug information provided by drug labeling services as well as lack of research in drug science results in potential drug interaction and compromise patient safety. 38 In Nigeria, at least two interacting drugs were prescribed to patient in tertiary care health settings and 55.6% was found to be the prevalence of DDIs.…”

Section: Drug Interaction Facts In Underdeveloped Nationsmentioning

confidence: 99%

Drug-Drug Interaction; Facts and Comparisons With National and International Bentch Marks. A Threat More Than a Challenge for Patient Safety in Clinical and Economic Scenario

Hasnain

Ali

Zafar

et al. 2017

TPMJ

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REVIEW PROF-3670ABSTRACT… Drug-drug interaction (DDI) is a specific type of adverse event, which develops due to multiple regimen therapy, and that may lead to significant hospitalization and death. Clinical and economic impact of drug interactions are increasingly accredited as a chief concern in critical care. Potentiating effects of DDIs in intensive care units are far more critical due to complex medications regimen, high risk severely ill population and associated metabolic and physiological disturbances which can impede drug effects. Pharmacist contribution is classified as clarification of drug order, appropriate drug information provision, and advice for substitute treatment. A multidisciplinary approach is very necessary in developing a pharmacotherapeutic regimen designed to optimize patient outcome and minimize any potential dug drug interactions. This review encompasses the prevalence, categorization, significance in term of patient safety and prescription efficacy, clinical and economic burdens, national and international data comparisons related to drug-drug interactions. Key words:Drug-drug interactions, clinical and economic impact, significance, patient safety.

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Prevalence of potential drug–drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia

Cited by 36 publications

References 12 publications

An exploratory study investigating the potential drug-drug interactions in internal medicine department, Alahsa, Saudi Arabia

An exploratory study investigating the potential drug-drug interactions in internal medicine department, Alahsa, Saudi Arabia

Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

Drug-Drug Interaction; Facts and Comparisons With National and International Bentch Marks. A Threat More Than a Challenge for Patient Safety in Clinical and Economic Scenario

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