Prevalence of periodontal pathogens with varying metabolic control of diabetes mellitus

Tervonen, Tellervo; Oliver, R. G.; Wolff, Larry F.; Bereuter, Janna; Anderson, L.; Aeppli, Dorothee

doi:10.1111/j.1600-051x.1994.tb00732.x

Cited by 64 publications

(44 citation statements)

References 25 publications

(34 reference statements)

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“…type 2 diabetic and nondiabetic populations (16,17). In the present study, P. gingivalis type II fimA was found to have a significant association with deterioration of periodontitis, whereas types I and IV clones were not related to disease progression.…”

mentioning

confidence: 54%

Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

Ojima

Takeda

Yoshioka³

et al. 2005

Diabetes Care

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mentioning

confidence: 54%

Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

Ojima

Takeda

Yoshioka³

et al. 2005

Diabetes Care

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“…All these biologically deleterious events taking place simultaneously may throw some light on the combined effect of diabetes and smoking on PPD and CAL found in our study. Furthermore, smoking creates a favorable environment for the growth of periodontal microbes in shallow periodontal pockets (21) but such phenomenon is not seen in patients with diabetes alone (22). Thus, results obtained can be justified to some extent by changes in the number and composition of periodontal pathogens.…”

Section: Discussionmentioning

confidence: 94%

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Gupta

Garg

et al. 2016

J Oral Sci

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The present study was carried out to evaluate the effect of type 2 diabetes mellitus (DM) and smoking on periodontal parameters and on the levels of salivary matrix metalloproteinase (MMP-8). One hundred and twenty five subjects were divided into five groups: group 1, systemically and periodontally healthy subjects (n = 25); group 2, systemically healthy subjects but with chronic periodontitis (n = 25); group 3, subjects with type 2 DM and chronic periodontitis (n = 25); group 4, smokers with chronic periodontitis (n = 25); group 5, diabetic-smokers with chronic periodontitis (n = 25). MMP-8 level in saliva was estimated by enzyme linked immunosorbent assay (ELISA) using Quantikine human total MMP-8 immunoassay kit. The result showed that the clinical periodontal parameters and the mean levels of the salivary MMP-8 were significantly higher for diabetic-smokers than other study groups. A highly significant positive correlation (r) between MMP-8 and periodontal parameters was also observed in diabetic-smoker patients. The findings suggest that diabetic-smokers have increased periodontal breakdown and are associated with an increased extent and severity of periodontitis. (J Oral Sci 58, 1-6, 2016)

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“…2,11 Differences among studies may be explained by the metabolic control used. 12,13 Scaling and root planing (SRP) therapy, in combination (or not) with antimicrobial agents, might be effective in reducing periodontal pathogens in persons with DM, 14,15 although others have reported that SRP alone may not be capable of eliminating or reducing Tannerella forsythia and Porphyromonas gingivalis in those individuals. 4,8,16,17,18 In general, a reduced level of those pathogens is crucial for a good response to therapy.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control

et al. 2014

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Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control abstract: The present study investigated the effect of non-surgical periodontal treatment (SRP) on the composition of the subgingival microbiota of chronic periodontitis (CP) in individuals with type 2 diabetes (DM2) with inadequate metabolic control and in systemically healthy (SH) individuals. Forty individuals (20 DM2 and 20 SH) with CP underwent full-mouth periodontal examination. Subgingival plaque was sampled from 4 deep sites of each individual and tested for mean prevalence and counts of 45 bacterial taxa by the checkerboard method. Clinical and microbiological assessments were performed before and 3 months after SRP. At baseline, those in the DM2 group presented a significantly higher percentage of sites with visible plaque and bleeding on probing compared with those in the SH group (p < 0.01). Those in the DM2 group presented significantly higher levels of C. rectus and P. gingivalis, and lower prevalence of P. micra and S. anginosus, compared with those in the SH group (p ≤ 0.001). At the 3-month visit, both groups showed a significant improvement in all clinical parameters (p < 0.01). Those in the DM2 group showed significantly higher prevalence and/ or levels of A. gerencseriae, A. naeslundii I, A. oris, A. odontolyticus, C. sputigena, F. periodonticum, and G. morbillorum compared with those in the SH group (p ≤ 0.001). However, those in the DM2 group showed a significant reduction in the levels of P. intermedia, P. gingivalis, T. forsythia, and T. denticola (p ≤ 0.001) over time. Those in the SRP group showed improved periodontal status and reduced levels of putative periodontal pathogens at 3 months' evaluation compared with those in the DM2 group with inadequate metabolic control.

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Prevalence of periodontal pathogens with varying metabolic control of diabetes mellitus

Cited by 64 publications

References 25 publications

Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control

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