Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

Ojima, Miki; Takeda, Masayoshi; Yoshioka, Hideo; Nomura, Midori; Tanaka, Noriaki; Kato, Takahiro; Shizukuishi, Satoshi; Amano, Atsuo

doi:10.2337/diacare.28.2.433

Cited by 30 publications

(30 citation statements)

References 21 publications

(15 reference statements)

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“…In the present study, the subgingival plaque sample presented a significantly higher level of Pg (44.7±13.3) in the diabetic group similar to a few reports, [27][28][29][30][31][32] and a few studies reported no difference between diabetic and nondiabetic patients. [28,29] Fn was significantly high in the diabetic, whereas Tf has not shown any significant difference between the diabetic and the nondiabetic, in contrast to reports suggesting Tf was less frequently associated with periodontal disease in NIDDM than in non-DM individuals.…”

Section: Resultssupporting

confidence: 89%

Detection of odoriferous subgingival and tongue microbiota in diabetic and nondiabetic patients with oral malodor using polymerase chain reaction

et al. 2011

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Section: Resultssupporting

confidence: 89%

Detection of odoriferous subgingival and tongue microbiota in diabetic and nondiabetic patients with oral malodor using polymerase chain reaction

et al. 2011

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“…Namely, it is considered that the increased serum levels of lipopolysaccharide and TNF-α associated with P. gingivalis infection induce insulin resistance, leading to the development of type 2 diabetes [30,31]. In addition, our colleagues reported relationship between the fimbrial type of the periodontal bacteria causing periodontitis and the risk of development of type 2 diabetes mellitus [32]. In fact, most NAFLD patients with P. gingivalis infection show bacteria with invasive types of fimbria, such as II, IV, and Ib.…”

Section: Discussionmentioning

confidence: 99%

Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease

et al. 2012

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BackgroundNon-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome that is closely associated with multiple factors such as obesity, hyperlipidemia and type 2 diabetes mellitus. However, other risk factors for the development of NAFLD are unclear. With the association between periodontal disease and the development of systemic diseases receiving increasing attention recently, we conducted this study to investigate the relationship between NAFLD and infection with Porphyromonas gingivalis (P. gingivalis), a major causative agent of periodontitis.MethodsThe detection frequencies of periodontal bacteria in oral samples collected from 150 biopsy-proven NAFLD patients (102 with non-alcoholic steatohepatitis (NASH) and 48 with non-alcoholic fatty liver (NAFL) patients) and 60 non-NAFLD control subjects were determined. Detection of P. gingivalis and other periodontopathic bacteria were detected by PCR assay. In addition, effect of P. gingivalis-infection on mouse NAFLD model was investigated. To clarify the exact contribution of P. gingivalis-induced periodontitis, non-surgical periodontal treatments were also undertaken for 3 months in 10 NAFLD patients with periodontitis.ResultsThe detection frequency of P. gingivalis in NAFLD patients was significantly higher than that in the non-NAFLD control subjects (46.7% vs. 21.7%, odds ratio: 3.16). In addition, the detection frequency of P. gingivalis in NASH patients was markedly higher than that in the non-NAFLD subjects (52.0%, odds ratio: 3.91). Most of the P. gingivalis fimbria detected in the NAFLD patients was of invasive genotypes, especially type II (50.0%). Infection of type II P. gingivalis on NAFLD model of mice accelerated the NAFLD progression. The non-surgical periodontal treatments on NAFLD patients carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.ConclusionsInfection with high-virulence P. gingivalis might be an additional risk factor for the development/progression of NAFLD/NASH.

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“…Most clinical studies agree that type II fimA is the most predominant type in patients affected by periodontitis, followed by genotype Ib (Amano et al (1) 20 (5) IV 0 (0) 4 (1) 0 (0) V 0 (0) 0 (0) 4 (1) I, Ib 8 (2) 28 (7) 24 (6) I, Ib, II 12 (3) 4 (1) 4 (1) I, Ib, II, IV 8 (2) 0 (0) 0 (0) I, Ib, III, IV 4 (1) 0 (0) 0 (0) I, Ib, V 4 (1) 0 (0) 4 (1) I, II 0 (0) 4 (1) 0 (0) I, III 0 (0) 0 (0) 4 (1) I, IV 0 (0) 4 (1) 0 (0) Ib, II 0 (0) 4 (1) 0 (0) II, IV 4 (1) 0 (0) 0 (0) I, II, IV 4 (1) 0 (0) 0 (0) 100 (25) 100 (25) 100 (25) Nakagawa et al 2002, Miura et al 2005, Ojima et al 2005; most of these studies were carried out in Japan. However, in a multiracial population such as in the Brazilian study, the most predominant type was Ib (Missailidis et al 2004), this finding agreeing with our results.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Genotypes of Porphyromonas gingivalis in Type 2 Diabetic Patients with Periodontitis in Mexico

Dávila-Pérez

Amano

Alpuche-Solís

et al. 2006

J Clinic Periodontology

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Relationship of Periodontal Bacterium Genotypic Variations With Periodontitis in Type 2 Diabetic Patients

Cited by 30 publications

References 21 publications

Detection of odoriferous subgingival and tongue microbiota in diabetic and nondiabetic patients with oral malodor using polymerase chain reaction

Detection of odoriferous subgingival and tongue microbiota in diabetic and nondiabetic patients with oral malodor using polymerase chain reaction

Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease

Distribution of Genotypes of Porphyromonas gingivalis in Type 2 Diabetic Patients with Periodontitis in Mexico

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