Prevalence of Parvovirus B19 and Human Bocavirus DNA in the Heart of Patients with no Evidence of Dilated Cardiomyopathy or Myocarditis

Abstract

Our data suggest that B19V but not HBoV demonstrates a lifelong persistence in the heart. The detection of B19V DNA in heart tissue showed no correlation with clinical symptoms. We strongly recommend that serological testing become a standardized procedure for future studies, to obtain representative data concerning the prevalence of B19V in the heart.

Widespread Infection with Homologues of Human Parvoviruses B19, PARV4, and Human Bocavirus of Chimpanzees and Gorillas in the Wild

“…PARV4 shows evidence for tissue persistence (33,37,52) and likely lifelong seropositivity after resolution of acute infections. Although several studies have failed to document an equivalent persistence of HBoV in lymphoid tissue, bone marrow, or skin (27,37,43), high frequencies of serological reactivity in human adults have been observed using a VP2-based ELISA similar to that used in the current study (8,17,30). These indicate a likely durable immune response and/or the occurrence of multiple infections that restimulate humoral antibody responses (17,38).…”

Virus Detection and Semiquantitation in Explanted Heart Tissues of Idiopathic Dilated Cardiomyopathy Adult Patients by Use of PCR Coupled with Mass Spectrometry Analysis

“…diseases, such as hydrops fetalis (31). Our group was the first, to our knowledge, to perform a standardized quantification of EV genomes in endomyocardial tissues of end-stage IDCM patients and to identify low levels of EV cardiac infection in IDCM patients (8).…”

DCMP as a Clinical Syndrome: Results of Nosological Diagnostics With Myocardial Biopsy and Differentiated Treatment in Virus-Positive and Virus-Negative Patients

“…Однако в литера-туре неоднократно показано, что у пациентов без воспалительных заболеваний сердца (врожденные пороки сердца, ишемическая КМП, любая диастоли-ческая ХСН, операции на открытом сердце у пациен-тов без ДКМП), и даже в общей популяции, частота обнаружения вирусного генома, особенно парвови-руса В19, составляет 17-95% [21][22][23][24][25] и едва ли не пре-восходит таковую у пациентов с синдромом ДКМП. В собственном исследовании мы получили этому подтверждение [4]: в группе сравнения у больных без систолической дисфункции, оперированных на открытом сердце по поводу ИБС, пороков сердца и ГКМП, вирусный геном был выявлен в 66% био-птатов, однако морфологические признаки миокар-дита -только в 24%.…”