Prevalence of methicillin-resistant Staphylococcus aureus in infected and uninfected diabetic foot ulcers

Abstract

This study investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in infected and uninfected diabetic foot ulcers of 84 patients with the two types of diabetes. S. aureus was the most common pathogen among the Gram-positive bacteria isolated from ulcers, and almost 50% of S. aureus isolates were MRSA. The prevalence of MRSA was significantly higher in patients with infected foot ulcers. MRSA infection or colonisation was not associated with factors (previous hospitalisation, use of antibiotics, etc.) known to predispose to MRSA colonisation or infection. The high prevalence of MRSA in patients with foot ulcers may reflect the increased prevalence of MRSA in the community.

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

“…In our study, MRSA was 6.70% and MSSA was 17%, but in other studies, the incidence of MRSA was 15 to 30%. 29,30 In the study of Perim et al, 31 the incidence of resistance of MRSA to vancomycin was 26%. Later on, in that study modified Kirby-Bauer disk diffusion demonstrated only three isolates resistant to vancomycin.…”

Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections

“…Our study found that different proportions of Staphylococcus aureus isolates were methicillinresistant. Previous studies have shown that almost 50% of Staphylococcus aureus isolates were methicillin-resistant, and MRSA is being increasingly isolated from diabetic foot ulcers (13) (32) . Other studies have identifi ed MRSA in as many as 15-30% of diabetic wounds (33) (34) .…”

Beneficial effects of implementing guidelines on microbiology and costs of infected diabetic foot ulcers

“…Enterobacteriaceae and P. aeruginosa Effect on microbiology laboratory and drug costs The number of samples decreased yearly, not only because the number of patients sampled decreased but also because the mean number of samples per patient decreased, leading to a decreasing mean cost per patient (Table 3) Values are median and interquartile ranges (25th to 75th percentile) or numbers and percentages a Grade 1 or 2 (see text for comments). For nephropathy, we used ADA criteria [29]: microalbuminuria and macroalbuminuria were defined by urinary albumin excretion between 30 and 299 mg/24 h and in excess of 300 mg/24 h, respectively; renal failure was diagnosed if creatinine clearance was lower than 60 ml/min, using Cockroft and Gault formula b Note that the total percentages per year are greater than 100% because more than one sampling technique was allowed in a single patient decreased ( Commensal bacteria included organisms such as coagulase-negative Staphylococcus, corynebacteria and Propionibacterium sp.…”