Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections

Perim, Michele Cezimbra; Borges, Joelma da Costa; Celeste, Stela Regina Costa; Orsolin, Ederson de Freitas; Mendes, Rafael Rocha; Mendes, Gabriella Oliveira; Ferreira, Roumayne Lopes; Carreiro, Solange Cristina; Pranchevicius, Maria Cristina da Silva

doi:10.1590/0037-8682-0146-2015

Cited by 76 publications

(80 citation statements)

References 32 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…35 Our study demonstrated 80 to 86% sensitivity of Pseudomonas to imipenem which was consistent with the study done by Rajalakshmi et al 37 On the contrary, only 50% Pseudomonas was sensitive to imipenem in the study done by Perim et al 31 Sivanmaliappan and Sevanan in their study demonstrated 100% resistance of Pseudomonas to ampicillin, 83% to tetracycline, 66.6% to gentamicin, and 16.6% to cefotaxime. There was some similarity as well as dissimilarity evidenced in our study.…”

Section: Discussionsupporting

confidence: 87%

“…There was some similarity as well as dissimilarity evidenced in our study. 38 More or less similarity in observations was demonstrated in the study of Perim et al 31 In our study, Pseudomonas was 100% resistant to ampicillin, amoxicillin, tetracycline, erythromycin, cefotaxime, clindamycin, vancomycin, teicoplanin, linezolid and around 50% resistant to aminoglycoside group of antibiotics. In the study, of Hailu et al, 33 it was demonstrated that P. aeruginosa was highly sensitive to ciprofloxacin, gentamicin, amikacin, and chloramphenicol.…”

Section: Discussionsupporting

confidence: 85%

“…On the contrary, our study demonstrated nearly 100% sensitivity and low level of resistance to levofloxacin. Enterobacteriaceae group was resistant to most of the antibiotics as evidenced in the study done by Banashankari et al, 40 whereas the study done by Perim et al 31 demonstrated gentamicin and imipenem were most effective to this group. The latter study was nearly consistent with our own study where enterobacteriaceae was nearly 50% sensitive to piperacillin-tazobactam (57.14%), imipenem (47.61%), chloramphenicol (52.38%), vanco mycin (42.85%).…”

Section: Discussionmentioning

confidence: 95%

“…In our study, MRSA was 6.70% and MSSA was 17%, but in other studies, the incidence of MRSA was 15 to 30%. 29,30 In the study of Perim et al, 31 the incidence of resistance of MRSA to vancomycin was 26%. Later on, in that study modified Kirby-Bauer disk diffusion demonstrated only three isolates resistant to vancomycin.…”

Section: Discussionmentioning

confidence: 97%

See 3 more Smart Citations

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Dhar¹,

Nandi²

2017

MGM Journal of Medical Sciences

View full text Add to dashboard Cite

Increasing emergence of drug-resistant bacteria is becoming a major problem globally. A retrospective study of 790 culture and sensitivity reports on microbial isolates, from infected wounds was carried out in KPC Medical College and Hospital, Jadavpur, Kolkata, India. 504 patients were males and 286 females. Gram negative organisms were isolated in 561 and gram positive in 229. Among the gram negative organisms, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli were the most common, whereas Staph aureus was the only gram positive organism isolated. Antibiotic sensitivity tests revealed most gram negative organisms susceptible to carbapenems, polymyxin and colistin. Staphylococci showed sensitivity to tigecycline, clindamycin, vancomycin, teicoplanin and linezolid. Interesting differences in the type of organisms isolated in male and female patients were noted. For example Enterococcus faecalis was found only in female patients. Increasing resistance of microorganisms cultured from infected wounds to first line and even second line antibiotics is a matter of great concern and can be attributed to indiscriminate and irrational use of broad spectrum antibiotics. This has to stop forthwith if we want to prevent resistance to antibiotics; otherwise morbidity, mortality and health care costs in treating patients with wound infections are going to increase exponentially

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Dhar¹,

Nandi²

2017

MGM Journal of Medical Sciences

View full text Add to dashboard Cite

show abstract

“…In a study by Raja polymicrobial growth was found in 42.8% and 57.2% patients had pure growth whereas in our study the rate of isolation was 34% and 66% respectively. Staphylococcus aureus is reported to be the predominant isolate in various studies (Goldstein et al, 1996), (Perim et al, 2015) whereas Gram negative organisms predominated in a study by Banashankari et al (Banashankari et al, 2012) and the common isolate was Proteus Spp. followed by E. coli.…”

Section: Resultsmentioning

confidence: 96%

Diabetic Foot Infections: Characterization and Antibiotic Resistance Pattern of Aerobic Bacterial Isolates in a Tertiary Care Hospital of North Kerala

George¹,

Ameena²

2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Epidemiology of Invasive Group B Streptococcal Infections Among Nonpregnant Adults in the United States, 2008-2016

et al. 2019

View full text Add to dashboard Cite

Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden of GBS infections among nonpregnant adults, particularly older adults and those with underlying medical conditions. OBJECTIVE To update trends of invasive GBS disease among US adults using population-based surveillance data. DESIGN, SETTING, AND PARTICIPANTS In this population-based surveillance study, a case was defined as isolation of GBS from a sterile site between January 1, 2008, and December 31, 2016. Demographic and clinical data were abstracted from medical records. Rates were calculated using US Census data. Antimicrobial susceptibility testing and serotyping were performed on a subset of isolates. Case patients were residents of 1 of 10 catchment areas of the Active Bacterial Core surveillance (ABCs) network, representing approximately 11.5% of the US adult population. Patients were included in the study if they were nonpregnant, were 18 years or older, were residents of an ABCs catchment site, and had a positive GBS culture from a normally sterile body site. MAIN OUTCOMES AND MEASURES Trends in GBS cases overall and by demographic characteristics (sex, age, and race), underlying clinical conditions of patients, and isolate characteristics are described. RESULTS The ABCs network detected 21 250 patients with invasive GBS among nonpregnant adults from 2008 through 2016. The GBS incidence in this population increased from 8.1 cases per 100 000 population in 2008 to 10.9 in 2016 (P = .002 for trend). There were 3146 cases reported in 2016 (59% male; median age, 64 years; age range, 18-103 years). The GBS incidence was higher among men than women and among blacks than whites and increased with age. Projected to the US population, an estimated 27 729 cases of invasive disease and 1541 deaths occurred in the United States in 2016. Ninety-five percent of cases in 2016 occurred in someone with at least 1 underlying condition, most commonly obesity (53.9%) and diabetes (53.4%). Resistance to clindamycin increased from 37.0% of isolates in 2011 to 43.2% in 2016 (P = .02). Serotypes Ia, Ib, II, III, and V accounted for 86.4% of isolates in 2016; serotype IV increased from 4.7% in 2008 to 11.3% in 2016 (P < .001 for trend). CONCLUSIONS AND RELEVANCE The public health burden of invasive GBS disease among nonpregnant adults is substantial and continues to increase. Chronic diseases, such as obesity and diabetes, may contribute.

show abstract

Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections

Cited by 76 publications

References 32 publications

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Diabetic Foot Infections: Characterization and Antibiotic Resistance Pattern of Aerobic Bacterial Isolates in a Tertiary Care Hospital of North Kerala

Epidemiology of Invasive Group B Streptococcal Infections Among Nonpregnant Adults in the United States, 2008-2016

Contact Info

Product

Resources

About