Prevalence of inducible clindamycin resistance in gram positive organisms in a tertiary care centre

Angel,; Balaji, V; Prakash, Jaj; Brahmadathan, K. N.; Mathews, Vikram

doi:10.4103/0255-0857.42041

Cited by 26 publications

(6 citation statements)

References 7 publications

(8 reference statements)

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“…These all studies shows that there is a wide variation in incidence of Clindamycin resistance among clinical isolates of Staphylococcus aureus in different geographical areas. The rate of inducible Clindamycin resistance in MRSA and MSSA in present study is 59.34% and 12.84% respectively which is comparable to Pal et al22 and Mittal et al29 Higher incidence of ICR positive cases in MRSA was reported by Angel at al30 (64% in MRSA). However higher percentage of ICR in MSSA as compared to MRSA have been reported by other studies like Schreckenberger et al31 and Levin et al10 9.25% and 68% respectively.…”

supporting

confidence: 85%

Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection

Panwala¹,

Gandhi²,

Jethwa³

2021

IJMMTD

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Now a days clinicians switch over to drug Clindamycin to treat Staphylococcus aureus infections. Clindamycin is belonging to lincosamide group. As frequent use of this Clindamycin develops resistance among patients and ultimately treatment failure. Aim: This present research is done to identify type of resistance like inducible or constitutive macrolide lincosamide-streptogramin B (iMLSB /cMLSB) resistance and MS (Macrolide lincosamide streptogramin) phenotypes among Staphylococcus aureus isolated from various samples received in Microbiology laboratory of tertiary care hospital of south Gujarat. Materials and Methods: Among various samples total 232 Staphylococcus aureus were isolated. And all these isolates were subjected to routine antibiotic sensitivity testing by kirbey bauer disc diffusion method. Methicillin resistance staphylococcus aureus (MRSA) detected by using Cefoxitin disc. D test is performed as per Clinical and laboratory standards institute (CLSI) guidelines on all isolates. Results: Total of 232 Staphylococcus aureus were isolated, among them 109 were Methicillin sensitive Staphylococcus aureus (MSSA) and 123 were Methicillin resistant Staphylococcus aureus (MRSA). Prevalence of iMLSB, cMLSB and MS phenotype were 59.34% ,15.44% and 13% in MRSA while 12.84%, 14.67% and 22.93% respectively in MSSA. Conclusion: This research helps to detect Clindamycin resistance among Staphylococcus aureus and role of D test before starting the treatment with Clindamycin. By these knowledge clinician can choose correct treatment and we can prevent a treatment failure.

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supporting

confidence: 85%

Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection

Panwala¹,

Gandhi²,

Jethwa³

2021

IJMMTD

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“…Clindamycin resistance was observed in 19/86 (22%) of the confirmed MRSA isolates in the current study, with inducible resistance seen in an additional 15 isolates. Notably, inducible resistance to clindamycin in MRSA (MLSB i phenotype) has been shown to compromise therapy (15, 16) indicating the need for routine monitoring and susceptibility testing for both constitutive and inducible clindamycin resistance (17, 18) prior to therapy against MRSA infections in Libyan hospitals.…”

Section: Discussionmentioning

confidence: 99%

Misidentification of methicillin-resistantStaphylococcus aureus(MRSA) in hospitals in Tripoli, Libya

Ahmed

Abuzweda²,

Alghazali³

et al. 2010

Libyan Journal of Medicine

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BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial (hospital-acquired) pathogen of exceptional concern. It is responsible for life-threatening infections in both the hospital and the community.AimsTo determine the frequency of MRSA misidentification in hospitals in Tripoli, Libya using current testing methods.MethodsOne hundred and seventy S. aureus isolates previously identified as MRSA were obtained from three hospitals in Tripoli. All isolates were reidentified by culturing on mannitol salt agar, API 20 Staph System and retested for resistance to methicillin using the cefoxitin disk diffusion susceptibility test and PBP2a. D-tests and vancomycin E-tests (Van-E-tests) were also performed for vancomycin-resistant isolates.ResultsOf the 170 isolates examined, 86 (51%) were confirmed as MRSA (i.e. 49% were misidentified as MRSA). Fifteen (17%) of the confirmed MRSA strains exhibited inducible clindamycin resistance. Of the 86 confirmed MRSA isolates, 13 (15%) were resistant to mupirocin, 53 (62%) were resistant to ciprofloxacin, 41 (48%) were resistant to trimethoprim-sulfamethoxazole, and none were resistant to linezolid. Although disc-diffusion testing indicated that 23 (27%) of the isolates were resistant to vancomycin, none of the isolates were vancomycin-resistant by Van-E-test.ConclusionsMisidentification of nosocomial S. aureus as MRSA is a serious problem in Libyan hospitals. There is an urgent need for the proper training of microbiology laboratory technicians in standard antimicrobial susceptibility procedures and the implementation of quality control programs in microbiology laboratories of Libyan hospitals.

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“…[ 26 ] Interestingly, in a study by Angel et al , there has been no constitutive MLS B resistance. [ 27 ]…”

Section: Microbiology Reportmentioning

confidence: 99%

Study of antibiotic resistance pattern in methicillin resistant staphylococcus aureus with special reference to newer antibiotic

Kaur

Chate

2015

J Global Infect Dis

146

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The worldwide epidemic of antibiotic resistance is in danger of ending the golden age of antibiotic therapy. Resistance impacts on all areas of medicine, and is making successful empirical therapy much more difficult to achieve. Staphylococcus aureus demonstrates a unique ability to quickly respond to each new antibiotic with the development of a resistance mechanism, starting with penicillin, until the most recent, linezolid and daptomycin. Methicillin resistant S. aureus (MRSA) has become endemic today in hospitals worldwide. Resistance to the newer antimicrobial-agents — linezolid, vancomycin, teicoplanin, and daptomycin are been reported and also the fear of pandrug-resistance. This study was carried out to know the antimicrobial resistant pattern of MRSA to newer antibiotic, to know any isolates are extensively-drug resistant (XDR)/pandrug resistant (PDR), inducible macrolide-lincosamide streptogramin B (iMLSB), and mupirocin resistance. Thirty-six MRSA isolates resistant to the routinely tested antibiotic were further tested for list of antibiotic by a group of international experts. Isolates were tested for iMLSB and mupirocin resistance by the disk diffusion method. Of 385 MRSA, 36 (9.35%) isolates of MRSA were resistant to the routinely tested antibiotic. Among these 36 MRSA isolates, none of our isolates were XDR/PDR or showed resistant to anti-MRSA cephalosporins (ceftaroline), phosphonic acids, glycopeptides, glycylcyclines, and fucidanes. Lower resistance was seen in oxazolidinones (2.78%), streptogramins (5.56%), lipopeptide (5.56%). Thirty-four (94.44%) isolates showed constitutive MLSB (cMLSB) resistance and two (5.56%) iMLSB phenotypes. High- and low-level mupirocin resistance were seen in 13 (36.11%) and six (16.67%), respectively. In our study, none of our isolates were XDR or PDR. No resistance was observed to ceftaroline, telavancin, teicoplanin, and vancomycin; but the presence of linezolid resistance (1, 2.28%) and daptomycin resistance (2, 5.56%) in our rural set-up is a cause of concern.

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Prevalence of inducible clindamycin resistance in gram positive organisms in a tertiary care centre

Cited by 26 publications

References 7 publications

Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection

Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection

Misidentification of methicillin-resistantStaphylococcus aureus(MRSA) in hospitals in Tripoli, Libya

Study of antibiotic resistance pattern in methicillin resistant staphylococcus aureus with special reference to newer antibiotic

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