Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China

Abstract

Existing data on the genotype distribution of human papillomavirus (HPV) are limited in Hunan province, central south China. To evaluate the prevalence of HPV infection and its genotype among women with invasive cervical cancer in Hunan, a total of 1,336 patients were included in this study between July 2012 and June 2013. Eighteen high-risk and eight low-risk genotypes of HPV were detected by Luminex xMAP technology. The results show that HPV prevalence in invasive cervical cancer in Hunan was 75.7%. A single HPV infection was found in 82.3% of the HPV-positive samples, and 91.8% of the cases had high-risk HPV infection. The most common HPV type was HPV 16 (50.6%), followed by HPV 58 (12.4%), HPV 52 (10.9%), HPV 18 (7.3%), HPV 33 (5.5%), HPV 59 (4.2%), HPV 39 (4.0%), HPV 61 (3.4%), HPV 31 (3.3%), and HPV 56 (3.2%). A single infection with HPV 16 was detected in 42.5% of the samples, which was significantly more frequent than any other HPV type in this population. Dual-infection with HPV 16 and HPV 52 were relatively common. The available vaccines for HPV 16 and 18 are therefore expected to have a substantial impact on reducing the burden of cervical cancer in China, even though HPV 18 showed a lower frequency. In addition to HPV 16 and 18, other HPV types including 58, 52, and 33, should be targeted in the next generation HPV vaccines.

Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

“…The cervical cancer group showed the highest rate of multiple infections. This result is in agreement with previous results [18, 19]. Among the five disease groups, the top three HPV subtypes in terms of infection were HPV-16, −52 and −58.…”

“…HPV-16 and -18 are the most prevalent HPV subtypes worldwide and are also the most common HPV subtypes in cervical cancer patients worldwide. Our result showed that the HPV-18 infection rate ranked relatively low in Hangzhou, which was in agreement with results reported in other regions of China [19, 20]. …”

Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

“…The majority of patients in the present study were HPV-positive, with high proportions of HPV 16, 58, 18, 52. Although the number of patients in the present study was small, the findings were consistent with previous reports regarding the global incidence of HPV , and 58 (27). Moreover, a high prevalence of HPV 52 and 58 genotypes in Southeast Asian countries has been reported previously (28)(29)(30).…”

Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China

“…Wang et al [15] reported that infections with multiple genotypes had higher risk of the development and progression of CC, but this does not necessarily mean that the cancerous stage requires multiple infections. Because cervical precursor lesions need years to develop into CC, multiple types may facilitate growth during the precancerous Cervical Intraepithelial Neoplasia (CIN) stages, but the oncogenic capability of the latter stages may not be controlled by multiple genotypes.…”