Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

Abstract

BackgroundHPV infection is the major pathogenic factor underlying cervical cancer and precancerous lesions. The cervical HPV infection rates in gynaecological outpatients from Hangzhou, China, were studied in the period from January 2011 to December 2015.MethodsExfoliated cervical cells were harvested from gynaecological outpatients in Hangzhou from January 2011 to December 2015. Twenty-one HPV subtypes were detected using flow-through hybridization. The HPV infection rates in various disease groups were compared using the Chi-square test. The infection rates of different HPV subtypes in different calendar years and in different age groups were analysed using the linear-by-linear association test and gamma value.ResultsA total of 43,804 patients were recruited, of whom 9752 (22.3%) were infected with HPV. The top five among the 21 HPV subtypes detected in terms of infection rates were HPV-16, −52, −58, −53 and −18. No significant differences (linear-by-linear association test) were found in the HPV infection rates when compared over the studied years (P > 0.05). However, the 15–24-year-old age group showed the highest HPV infection rate, and significant differences (linear-by-linear association test) were detected among the different age groups (P < 0.05). The HPV infection rates exhibited an upward trend in the 15–24-year-old and >24–34-year-old groups over the past five years. There were significant differences in the HPV infection rates among the disease groups (P < 0.05).ConclusionsHPV-16, −52 and −58 were the major HPV infection subtypes in Hangzhou, China. The 15–24-year-old age group had a relatively high HPV infection rate with an upward trend over the past five years and thus represented a population susceptible to HPV infection.

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

“…Our study found that the prevalent detection of HPV52 and HPV58 was ranked first and third among gynecological outpatients and ranked first and second among women receiving physical examinations, which deserved more attention by cancer prevention strategies. Although HPV18 is prevalent in Zhejiang and in Meizhou city of northeastern Guangdong, our study found that the prevalent detection of HPV18 was relatively low among both groups. Compared with women receiving physical examinations, the prevalent detection of HPV16, 18, 31, 33, 39, 52, 58, 68, 6, and 11 was significantly higher among gynecological outpatients ( P < .05).…”

“…However, our result differed from the dominant HR HPV subtype distributions among gynecological outpatients reported in other regions of China. For example, in Zhejiang province, the main genotypes of HR HPV were HPV16, 52, 58, 53, and 18 . In Fujian province, the main genotypes of HR HPV were HPV16, 52, 58, 53, and 33 .…”

“…The 21 HPV genotypes tested were classified into 6/11, 16/18, 4vHPV (6, 11, 16, and 18), 9vHPV (6,11,16,18,31,33,45, 52, and 58), HR HPV (16,18,31,33,35,39,45,51,52,53,56,58,59, 66, and 68), and LR HPV (6,11,42,43,44 and CP8304) according to their association with cervical intraepithelial neoplasia. 18 For participants detected with multiple HPV genotypes, HPV positivity was calculated for individual HPV genotypes.…”

“…Our results showed that the prevalent detection of any HPV subtypes among gynecological outpatients in Guangdong was 20.16%, which was higher than HPV prevalence in Hubei (17.68%) 20 and lower than that in Fujian (38.3%) 13 and Zhejiang (22.3%). 11 Considering the same laboratory method (Chaozhou Hybribio Limited Corporation, Chaozhou, China) in HPV detection among these studies, the diversity in HPV prevalence might mainly be attributed to geographical variation. Besides, different survey period may also be one of the reasons for the difference in HPV prevalence.…”

“…and 59 contribute to 96.6% of invasive cervical cancer cases diagnosed worldwide and HPV16 and 18 are associated with 70% cases. 4 LR HPV genotypes including HPV6, 11,40,42,43, and 44 are associated with hyperplasic lesions or genital warts. 4 About 90% of genital wart cases are caused by HPV6 and 11.…”