Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China

Abstract

BackgroundThere is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and genotypes among different female age groups in this region.MethodsTwenty-six HPV strains (low-risk HPV 6, 11, 40, 42, 44, 61, 73 and high-risk HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 82, and 83) were detected using Tellgenplex™ HPV technology in samples obtained from three clinical hospitals located in different regions of the Taihu Lake Basin.ResultsThe results showed that 1855 samples (20.97% of all samples) were found to be HPV-positive. Of these, 1375 samples (15.55% of all samples) were found to have a single HPV infection. Age-specific prevalence showed two peaks, one that corresponded to the group of 21–30 year-old women and the other peak that corresponded to the group of women over 51 years old. The three most prevalent genotypes were HPV52 (19.95%, 370/1855), HPV16 (13.48%, 150/1855), and HPV58 (11.32%, 210/1855). Mixed strains HPV58 + HPV33 and HPV58 + HPV52 were most commonly found in females infected with multiple HPV types.ConclusionsThis investigation reveals that HPV infection in the Taihu River Basin varied significantly among different age groups. The most prevalent genotypes are included in the nonavalent vaccine, V503, however this vaccine is not licensed for use in mainland China. The most frequently occurring genotypes should be considered in the development of next-generation HPV vaccines for optimal protection of public health.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2328-6) contains supplementary material, which is available to authorized users.

Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

“…In China, the bimodal curve of age‐specific HPV distribution is still controversial . In our report, for women aged 55 years or older, the hr‐HPV prevalence was 88.0% and 78.6% among HSIL and ICC patients, respectively, but there was no statistical difference in the overall age‐specific HPV/hr‐HPV distribution.…”

“…In China, the bimodal curve of age-specific HPV distribution is still controversial. 27,28 In our report, for women aged 55 years or older, the hr-HPV prevalence was 88.0% and 78.6% among HSIL and…”

Prevalence and distribution of cervical human papillomavirus genotypes in women with cytological results from Sichuan province, China

“…The epidemiologic characteristics of HPV genotypes vary by age, ethnicity, geographic location, and socioeconomic status. The “two‐peak pattern” of hrHPV infection among the different age group of women had been reported previously, while it is not common in several other studies in China . Some studies have shown that women younger than 25 years and older than 50 years were observed to be two of the most sensitive groups to hrHPV infection, while the shape of the pattern differs geographically.…”

“…in Sichuan, which was lower than that of a previous study conducted in Sichuan (31.5%). 14 It is still controversial whether the age-specific HPV distribution presents a bimodal curve (two-peak pattern) [4][5][6] in Mainland China. In our study, we observed a bimodal curve just like a U-shape in the overall age-specific HPV distribution.…”

Prevalence of Human Papillomavirus Infection and Genotype Distribution Determined via Real-Time PCR in a Korean Medical Check-up Population

“…More than 100 genotypes of HPV have been identified, and around 20 distinct HPV types have been associated with cervical carcinoma [14]. Depending on the oncogenic potential, HPV genotypes are categorized into high-risk types, which include HPV 16,18,31,33,35,39,45,51,52,56,58,59,68,69,73, and 82, and low-risk types, which include HPV 6,11,42,43,and 44 [15]. High-risk types of HPV are considered the main risk factors for cervical cancer, with HPV 16 being the most prevalent type in women with normal cytology and women with cervical carcinoma or CIN, whereas low-risk types such as HPV 6 and 11 generally only cause benign lesions or have been rarely associated with cervical carcinoma [1,16,17].…”