Prevalence of hospitalisation caused by adverse drug reactions at an internal medicine ward of a single centre in Japan: a cross-sectional study

Abstract

ObjectivesFew studies have investigated the prevalence of adverse drug reactions (ADRs) leading to hospitalisation in Japan. The aim of this study was to determine the prevalence of ADRs leading to hospitalisation and to evaluate the preventability of these ADRs in Japan.DesignA single-centre cross-sectional study using electronic medical records.SettingAcute care hospital.ParticipantsAll 1545 consecutive hospital admissions to an internal medicine ward due to acute medical illnesses from April 2017 to May 2018. The median patient age was 79 years (IQR 66–87), and the proportion of women was 47.9%.Outcome measuresThe primary outcome was the proportion of hospitalisations caused by ADRs among all hospitalisations. All suspected cases of ADRs were independently evaluated by two reviewers, and disagreements were resolved by discussion. The causality assessment for ADRs was performed by using the WHO-Uppsala Monitoring Committee criteria. The contribution of ADRs to hospitalisation and their preventability were evaluated based on the Hallas criteria.ResultsOf the 1545 hospitalisations, 153 hospitalisations (9.9%, 95% CI 8.4% to 11.4%) were caused by 200 ADRs. Cardiovascular agents (n=46, 23.0%), antithrombic agents (n=33, 16.5%), psychotropic agents (n=29, 14.5%) and non-steroidal anti-inflammatory drugs (n=24, 12.0%) accounted for approximately two-thirds of all ADRs leading to hospitalisation. Of 153 hospitalisations caused by ADRs, 102 (66.7%) were judged to be preventable.ConclusionsSimilar to other countries, one in every ten hospitalisations is caused by ADRs according to data from an internal medicine ward of a Japanese hospital. Most of these hospitalisations are preventable. Some efforts to minimise hospitalisations caused by ADRs are needed.

Prevalence of urgent hospitalizations caused by adverse drug reactions: a cross-sectional study

“…This means that the prevalence of hospital admissions due to ADRs has not significantly improved during the last decade. However, compared with the findings of a previous recent study 19 using almost the same methods, the prevalence of hospital admissions due to ADRs in the present study was reduced by approximately half. In Japan, the “Proper Medication Guideline for Older Adults” was published for healthcare providers in May 2018 20 , and polypharmacy reduction incentives were initiated in 2016 21 and 2018 22 .…”

Hubungan Tingkat Kejadian Efek Samping Antiinflamasi Non Steroid dengan Usia dan Jenis Kelamin

“…Penelitian yang dilakukan pada 1000 pasien di RS Singapura menyebutkan bahwa 12,4% pasien mengalami ADR terkait dengan pemberian obat cardiovascular (Chan dkk., 2016). ADRs yang terjadi pada penggunaan NSAIDs sebanyak 12% (Komagamine & Kobayashi, 2019). ADR yang banyak ditemukan pada penggunaan NSAIDs yaitu sebanyak 56,7% merupakan gangguan pada gastrointestinal seperti dispepsia, diare, konstipasi, mual, muntah, dan gastritis dan 16,7% ganguan pada kardiovaskular seperti hipertensi dan hipotensi (Rahmawati dkk., 2008).…”

Validation of quality indicators for evaluating geriatric pharmacotherapy services in primary care: a mixed methods study

“…Polypharmacy and inappropriate use of medicines are associated with an increased risk of adverse drug reactions and drug interactions. [1][2][3][4] As most medicines are prescribed and used in primary care, the quality of primary care services is increasingly important to minimise harm from medicine use.…”