Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates

Abstract

Neonatal hyperbilirubinemia is associated with various clinical comorbidities. G6PD deficiency is found to one important cause of neonatal jaundice developing on day 2 onwards.

Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

“…African, Asian, Mediterranean and Middle-Eastern descents are most commonly affected by this disorder 7 8. The prevalence of G6PD deficiency among Egyptian neonates is 8.9% 9. G6PD enzymatic deficiency was first reported in India, and its prevalence varies a lot from place to place 9.…”

“…The prevalence of G6PD deficiency among Egyptian neonates is 8.9% 9. G6PD enzymatic deficiency was first reported in India, and its prevalence varies a lot from place to place 9. Haemolysis in patients with G6PD deficiency can be triggered by specific agents, including certain foods, drugs and infections 6.…”

“…Haemolysis in patients with G6PD deficiency can be triggered by specific agents, including certain foods, drugs and infections 6. Avoiding the triggers and starting treatment early, including intensive phototherapy, to decrease the incidence of severe haemolysis are simple and inexpensive and can be started before the symptoms appear 8–10. Counselling with regard to avoiding the risks of jaundice and triggering agents should be directed to parents of deficient newborns 10.…”

“…G6PD deficiency is commonly known in Egypt as fava bean anaemia or favism (after intake of fava bean), as this enzyme deficiency increases the susceptibility of red blood cells to agents such as oxidants present in raw beans, some medications and oxidative stress caused by infections 11. There are few studies conducted on the prevalence of G6PD deficiency among Egyptian neonates with jaundice,9 as well as on the knowledge, attitude and practice (KAP) towards NNJ or G6PD deficiency 11 12. However, data on the prevalence and measurement of KAP in both NNJ and G6PD deficiency from a single study are not available.…”

Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat

“…A recent review noted the lack of empirical evidence of the efficacy of such programs in reducing the risk of severe hyperbilirubinemia, but nevertheless echoed this recommendation on the basis of the available evidence and understanding [1,9,10,31,53,56,62,63,64,65,66]. While screening of cord-blood for G6PD deficiency is of relatively low cost, the experience of the DOTYR-15 participants is that there would need to be a substantial investment in infrastructure to support universal screening programs.…”