2016
DOI: 10.1159/000445708
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Abstract: Severe neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥20 mg/dl, is associated with a higher risk of permanent neurological sequelae and death. Jaundice can and should be promptly diagnosed and treated. Reliable methods for TSB assay are not always readily available, particularly in low- and middle-income countries, making the true incidence of severe neonatal jaundice (NNJ) difficult to estimate. To gather a more comprehensive picture, a symposium addressing NNJ worldwide was organized du… Show more

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Cited by 122 publications
(127 citation statements)
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“…Previous studies reported varied worldwide incidence rates of severe hyperbilirubinaemia about 0.02 –0.12‰ live births4 in high-income countries, and 68–491‰ in mid-income or low-income countries 5. High rates of kernicterus (16.8%–31.6%) and mortality (9.2%–15.8%) were found in NJ cases admitted in Taiwan during the 1970s 3.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies reported varied worldwide incidence rates of severe hyperbilirubinaemia about 0.02 –0.12‰ live births4 in high-income countries, and 68–491‰ in mid-income or low-income countries 5. High rates of kernicterus (16.8%–31.6%) and mortality (9.2%–15.8%) were found in NJ cases admitted in Taiwan during the 1970s 3.…”
Section: Discussionmentioning
confidence: 99%
“…Of the 3 guidelines, the AAP has the lowest qualifying threshold between 24 and 42 h of age, while NICE has the highest qualifying threshold as from 78 h postnatally. As it is not uncommon to have local treatment protocols in some countries that differ from the AAP or NICE recommendations [15], we also evaluated the single threshold of TSB ≥12 mg/dL for healthy infants with normal weight (≥2.5 kg) that is prevalent in this study population [17,20]. …”
Section: Methodsmentioning
confidence: 99%
“…However, limited evidence exists on the use of TcB as proxy for TSB in initiating phototherapy, particularly in resource-limited countries where timely and routine TSB determination is not readily available but the burden of severe hyperbilirubinemia is high [15,16,17]. The impact of different phototherapy criteria on the utility of TcB is also unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Severe hyberbilirubinemia is preventable with early diagnosis, continued monitoring, and treatment with phototherapy. 257 Traditional laboratory approaches use either chemical determination, such as the diazo method, or spectrophotometry on blood samples to measure total serum bilirubin concentration.…”
Section: Diagnostics For Neonatal Healthmentioning
confidence: 99%