Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

Abstract

BackgroundNeonatal jaundice (NNJ) is a frequent complication of glucose-6-phosphate dehydrogenase (G6PD) deficiency.ObjectivesTo estimate the prevalence of G6PD deficiency among neonates with jaundice and to assess mothers’ perception towards G6PD and NNJ.MethodsA cross-sectional study was carried out on 487 ethnic Egyptian neonates with indirect hyperbilirubinaemia from June 2018 to July 2019. The collected data included maternal and neonatal characteristics. Laboratory investigations included serum bilirubin, reticulocyte count, ABO grouping, Rh typing and neonatal serum G6PD test. Mothers were interviewed individually using a structured, researcher-administered questionnaire to assess their perceptions of G6PD deficiency and NNJ.ResultsThe prevalence of G6PD deficiency was 10.10%. Neonates with G6PD deficiency showed higher levels of serum bilirubin (p<0.001). Male gender, family history of G6PD deficiency and consanguinity were risk factors for G6PD deficiency (OR=4.27, 95% CI 1.66 - 10.99; OR=9.54, 95% CI 4.80- 18.95; OR=10.219, 95% CI 5.39 - 19.33, respectively). Mothers’ perceptions of NNJ and G6PD were low, with only 30% having good knowledge on NNJ and 17.10% on G6PD deficiency, 46.8% with positive attitude towards NNJ and 45.0% towards G6PD deficiency, and 29.9% with good practice towards NNJ and 19.9% towards G6PD deficiency.ConclusionG6PD deficiency seems to be an important cause of NNJ. Mothers’ perceptions of both NNJ and G6PD deficiency were low. A mass health education programme on both of these diseases is needed to ensure better and early detection, good timing of treatment, and better prevention of the triggering factors to ensure better health for children.

Maternal knowledge, attitudes and practices related to neonatal jaundice and associated factors in Shenzhen, China: a facility-based cross-sectional study

“…In this study, 45.4% of mothers had good knowledge about neonatal jaundice. This knowledge level was better than that reported in other countries such as Nepal 23 (22%), Egypt 24 (30%) and Karbala city, Iraq 25 (34%). This may be attributed to the high proportion (83.1%) of our respondents who had graduated from university.…”

“…Our study also found that education level was significantly associated with knowledge about neonatal jaundice, which was consistent with the results of an earlier review. 26 Due to differences in scoring algorithms or items investigating attitudes and practices, [23][24][25] it was difficult to compare attitudes and behaviours reported in our study with those from other countries. The majority (80.6%) of participants in this study had received prior health education on neonatal jaundice, which suggested that their knowledge about neonatal jaundice would be high.…”

Genetic Spectrum and Clinical Early Natural History of Glucose-6-Phosphate Dehydrogenase Deficiency in Mexican Children Detected Through Newborn Screening.

“…Several authors have found that the prevalence of G6PDd is higher in jaundiced newborns than in the control population, ranging from 8.9 to 28.1% [26][27][28][29][30] (Table 3). Even some individuals carrying the hypomorphic G6PD A− 202A/376G haplotype had enzymatic values that were close to the cutoff value (5.3 U/g Hb, 4.6 and 4.8 U/g Hb in the groups with and without NNJ, respectively), while other individuals showed extremely low enzymatic values (1.1 U/g Hb and 1.4 U/g Hb in the NNJ and without NNJ groups, respectively).…”

“…Several authors have found that the prevalence of G6PDd is higher in jaundiced newborns than in the control population, ranging from 8.9 to 28.1% [26][27][28][29][30]. Badejoko G6PDd families with more than one affected patient (Table 4), in which only two patients had antecedent NNJ and one of them had a hemyzygous G6PD A− 202A/376G genotype (class III) experienced two episodes of AHA at the ages of 9 and 24 months old, respectively (Table 4).…”

Community pharmacists’ knowledge about medication use in glucose-6-phosphate-dehydrogenase G6PD deficiency in Khartoum, Sudan: A descriptive study

“…On the other hand, most of them stated that ascorbic acid, aspirin, and probenecid 80%, 66%, and 74% respectively as medications that can be used with caution in G6PD deficient patients. [2,4,5,16,18] . Most of the current study participants aged 25-34 years, this explains why 44% were senior pharmacist i.e.…”